Design and synthesis of 2-Substituted-4-benzyl-5-methylimidazoles as new potential Anti-breast cancer agents to inhibit oncogenic STAT3 functions.

Autor: Beshay BY; Department of Pharmaceutical Chemistry, College of Pharmacy, Arab Academy for Science, Technology and Maritime Transport, Alexandria, Egypt., Abdellatef AA; Section of Host Defences, Institute of Natural Medicine, University of Toyama, Toyama, Japan., Loksha YM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sinai University, Al-Arish, North Sinai, Egypt., Fahmy SM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, 2152 Alexandria, Egypt., Habib NS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, 2152 Alexandria, Egypt., Bekhit AEA; Department of Food Science, University of Otago, Dunedin, New Zealand., Georghiou PE; Department of Chemistry, Memorial University of Newfoundland, St. John's, NL, Canada., Hayakawa Y; Section of Host Defences, Institute of Natural Medicine, University of Toyama, Toyama, Japan. Electronic address: haya@inm.u-toyama.ac.jp., Bekhit AA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, 2152 Alexandria, Egypt; Pharmacy Program, Allied Health Department, College of Health and Sport Sciences, University of Bahrain, Bahrain; Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt. Electronic address: adnbekhit@pharmacy.alexu.edu.eg.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2021 Aug; Vol. 113, pp. 105033. Date of Electronic Publication: 2021 May 27.

Synthesis of pyrazolo-1,2,4-triazolo[4,3-a]quinoxalines as antimicrobial agents with potential inhibition of DHPS enzyme.

Autor: Z El-Attar MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt., Elbayaa RY; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy & Drug Manufacturing, Pharos University in Alexandria, Alexandria, Egypt., Shaaban OG; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy & Drug Manufacturing, Pharos University in Alexandria, Alexandria, Egypt., Habib NS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt., Abdel Wahab AE; Genetic Engineering & Biotechnology Research Institute (GEBRI), the City for Scientific Research & Technology Application, Borg El-Arab, Alexandria, Egypt., Abdelwahab IA; Department of Microbiology & Immunology, Faculty of Pharmacy& Drug Manufacturing, Pharos University in Alexandria, Alexandria, Egypt., M El-Hawash SA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.

Publikováno v: Future medicinal chemistry [Future Med Chem] 2018 Sep 01; Vol. 10 (18), pp. 2155-2175. Date of Electronic Publication: 2018 Aug 08.

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Design, synthesis, anti-inflammatory evaluation, and molecular modelling of new coumarin-based analogs combined curcumin and other heterocycles as potential TNF-α production inhibitors via upregulating Nrf2/HO-1, downregulating AKT/mTOR signalling pathways and downregulating NF-κB in LPS induced macrophages

Autor: Ghany, Lina M. A. Abdel¹ (AUTHOR), Beshay, Botros Y.² (AUTHOR) Botros_beshay@aast.edu, Youssef Moustafa, Amal M.³ (AUTHOR), Maghrabi, Ali Hassan Ahmed⁴ (AUTHOR), Ali, Eman Hussain Khalifa⁵ (AUTHOR), Saleem, Rasha Mohammed⁶ (AUTHOR), Zaki, Islam⁷ (AUTHOR), Ryad, Noha⁸ (AUTHOR)

Publikováno v: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2023, Vol. 38 Issue 1, p1-13. 13p.

Synthesis and biological evaluation of some novel thieno[2,3-d] pyrimidine derivatives as potential anti-inflammatory and analgesic agents.

Autor: El-Tombary AA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt. soadhawash@yahoo.com., El-Hawash SA, Habib NS, Soliman R, El-Ashmawy IM, Shaaban OG

Publikováno v: Medicinal chemistry (Shariqah (United Arab Emirates)) [Med Chem] 2013 Dec; Vol. 9 (8), pp. 1099-112.