Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Habib Abul Muntasir"'
Autor:
Habib Abul Muntasir, Murad Hossain, Mohiuddin Ahmed Bhuiyan, Tadazumi Komiyama, Takashi Nakamura, Masanobu Ozaki, Takafumi Nagatomo
Publikováno v:
Journal of Pharmacological Sciences, Vol 104, Iss 3, Pp 274-277 (2007)
Based on radio-ligand binding and molecular modeling studies, sarpogrelate shows a moderate selectivity for 5-HT2B versus 5-HT2A receptors. To confirm the modeling data of sarpogrelate to 5-HT2B receptors predicting interaction of sarpogrelate toward
Externí odkaz:
https://doaj.org/article/ea6f7292e4fd4e53a7f7516a8e6c17ce
Autor:
Maruf Ahmed, Habib Abul Muntasir, Murad Hossain, Masaji Ishiguro, Tadazumi Komiyama, Ikunobu Muramatsu, Hitoshi Kurose, Takafumi Nagatomo
Publikováno v:
Journal of Pharmacological Sciences, Vol 102, Iss 2, Pp 167-172 (2006)
We obtained a new mutant of the β1-adrenergic receptor (β1-AR) by point mutations that can constitutively activate β1-AR. Aspartate104 of the β1-AR in the 2nd transmembrane was replaced with alanine. The β1-AR mutant expressed in human embryonic
Externí odkaz:
https://doaj.org/article/3d634c84f06347f5abb44f6077455725
Publikováno v:
Journal of Pharmacological Sciences, Vol 102, Iss 1, Pp 55-63 (2006)
The purpose of the present study was to examine 5-hydroxytryptamine (5-HT)2A-receptor sarpogrelate interactions by site-directed mutagenesis. Based on molecular modeling studies, aspartic acid (Asp)155[3.32] and tryptophan (Trp)151[3.28] in transmemb
Externí odkaz:
https://doaj.org/article/ce111e66bd294ef69ae4f21f741d38ca
Autor:
Habib Abul Muntasir, Mohiuddin Ahmed Bhuiyan, Masaji Ishiguro, Masanobu Ozaki, Takafumi Nagatomo
Publikováno v:
Journal of Pharmacological Sciences, Vol 102, Iss 2, Pp 189-195 (2006)
Mutations producing constitutively active G-protein coupled receptors have been found in the pathophysiology of several diseases, implying that inverse agonists at the constitutively active receptors may have preferred therapeutic applications. Becau
Externí odkaz:
https://doaj.org/article/89c41733033a43e4a3430afc5334d2c2
Autor:
Takumichi Sugihara, Takafumi Nagatomo, Mohiuddin Ahmed Bhuiyan, Habib Abul Muntasir, Murad Hossain, Mamunur Rashid, Masaji Ishiguro
Publikováno v:
Biological & Pharmaceutical Bulletin. 35:1553-1559
We previously reported that sarpogrelate, a selective 5-HT2A antagonist, showed a potent inverse agonist activity to constitutively active mutant (C322K) of human 5-HT2A receptor (5-HT2AR). However, it remains to be unknown about the actual mechanism
Autor:
Takafumi Nagatomo, Ikunobu Muramatsu, Maruf Ahmed, Murad Hossain, Habib Abul Muntasir, Hitoshi Kurose, Masaji Ishiguro, Tadazumi Komiyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 102, Iss 2, Pp 167-172 (2006)
We obtained a new mutant of the β1-adrenergic receptor (β1-AR) by point mutations that can constitutively activate β1-AR. Aspartate104 of the β1-AR in the 2nd transmembrane was replaced with alanine. The β1-AR mutant expressed in human embryonic
Publikováno v:
Journal of Pharmacological Sciences, Vol 102, Iss 1, Pp 55-63 (2006)
The purpose of the present study was to examine 5-hydroxytryptamine (5-HT)2A-receptor sarpogrelate interactions by site-directed mutagenesis. Based on molecular modeling studies, aspartic acid (Asp)155[3.32] and tryptophan (Trp)151[3.28] in transmemb
Autor:
Masaji Ishiguro, Masanobu Ozaki, Mohiuddin Ahmed Bhuiyan, Habib Abul Muntasir, Takafumi Nagatomo
Publikováno v:
Journal of Pharmacological Sciences, Vol 102, Iss 2, Pp 189-195 (2006)
Mutations producing constitutively active G-protein coupled receptors have been found in the pathophysiology of several diseases, implying that inverse agonists at the constitutively active receptors may have preferred therapeutic applications. Becau
Publikováno v:
Pharmacology & Therapeutics. 104:59-81
The serotonin (5-hydroxytryptamine, 5-HT) receptors have conventionally been divided into seven subfamilies, most of which have several subtypes. Among them, 5-HT(2A) receptor is associated with the contraction of vascular smooth muscle, platelet agg
Autor:
Habib Abul Muntasir, Takafumi Nagatomo, Mikio Nakazawa, Masatomo Watanabe, Mamunur Rashid, Masanobu Ozaki
Publikováno v:
Biological and Pharmaceutical Bulletin. 26:1184-1187
The aim of the present study was to investigate the binding affinities and dissociation potencies of several 5-HT(2) antagonists in M(2) muscarinic receptor of rat heart membranes using [(3)H]QNB as a radioligand. The 5-HT(2) antagonists used in this