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Akademický článek

ABT-165, a Dual Variable Domain Immunoglobulin (DVD-Ig) Targeting DLL4 and VEGF, Demonstrates Superior Efficacy and Favorable Safety Profiles in Preclinical Models.

Autor: Li Y; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Hickson JA; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Ambrosi DJ; AbbVie Bioresearch Center, Worcester, Massachusetts., Haasch DL; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Foster-Duke KD; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Eaton LJ; AbbVie Bioresearch Center, Worcester, Massachusetts., DiGiammarino EL; Global Protein Sciences, AbbVie Inc., North Chicago, Illinois., Panchal SC; Global Protein Sciences, AbbVie Inc., North Chicago, Illinois., Jiang F; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Mudd SR; Translational Imaging, AbbVie Inc., North Chicago, Illinois., Zhang C; Drug Metabolism and Pharmacokinetics - Bioanalysis, AbbVie Biotherapeutics, Redwood City, California., Akella SS; Preclinical Safety, AbbVie Biotherapeutics, Redwood City, California., Gao W; Drug Metabolism and Pharmacokinetics, AbbVie Inc., North Chicago, Illinois., Ralston SL; Preclinical Safety, AbbVie Inc., North Chicago, Illinois., Naumovski L; Oncology Early Development, AbbVie Inc., Redwood City, California., Gu J; AbbVie Bioresearch Center, Worcester, Massachusetts., Morgan-Lappe SE; Oncology Discovery, AbbVie Inc., North Chicago, Illinois. susan.morgan-lappe@abbvie.com.

Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2018 May; Vol. 17 (5), pp. 1039-1050. Date of Electronic Publication: 2018 Mar 28.

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Akademický článek

Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.

Autor: Comess KM; Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, United States. kenneth.m.comess@abbott.com, Sun C, Abad-Zapatero C, Goedken ER, Gum RJ, Borhani DW, Argiriadi M, Groebe DR, Jia Y, Clampit JE, Haasch DL, Smith HT, Wang S, Song D, Coen ML, Cloutier TE, Tang H, Cheng X, Quinn C, Liu B, Xin Z, Liu G, Fry EH, Stoll V, Ng TI, Banach D, Marcotte D, Burns DJ, Calderwood DJ, Hajduk PJ

Publikováno v: ACS chemical biology [ACS Chem Biol] 2011 Mar 18; Vol. 6 (3), pp. 234-44. Date of Electronic Publication: 2011 Jan 20.

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Akademický článek

Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice.

Autor: Yang R; Department of Metabolic Disease Research, Abbott Laboratories, Abbott Park, Illinois 60064, USA. ruojingyang@yahoo.com, Wilcox DM, Haasch DL, Jung PM, Nguyen PT, Voorbach MJ, Doktor S, Brodjian S, Bush EN, Lin E, Jacobson PB, Collins CA, Landschulz KT, Trevillyan JM, Rondinone CM, Surowy TK

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2007 Aug 03; Vol. 282 (31), pp. 22765-74. Date of Electronic Publication: 2007 Jun 05.

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Akademický článek

Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies.

Autor: Liu M; Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064-6098, USA. mei.liu@abbott.com, Wang S, Clampit JE, Gum RJ, Haasch DL, Rondinone CM, Trevillyan JM, Abad-Zapatero C, Fry EH, Sham HL, Liu G

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Feb 01; Vol. 17 (3), pp. 668-72. Date of Electronic Publication: 2006 Nov 02.

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Akademický článek

Delivery of RNAi reagents in murine models of obesity and diabetes.

Autor: Wilcox DM; Metabolic Disease Research, in vivo Chemical Genomics, Department R4CY, 100 Abbott Park Road, Abbott Laboratories, Abbott Park, IL 60064, USA., Yang R, Morgan SJ, Nguyen PT, Voorbach MJ, Jung PM, Haasch DL, Lin E, Bush EN, Opgenorth TJ, Jacobson PB, Collins CA, Rondinone CM, Surowy T, Landschulz KT

Publikováno v: Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research [J RNAi Gene Silencing] 2006 Nov 29; Vol. 3 (1), pp. 225-36. Date of Electronic Publication: 2006 Nov 29.

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Akademický článek

Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: targeting the gatekeeper residue and beyond.

Autor: Liu G; Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064-6101, USA. gang.liu@abbott.com, Zhao H, Liu B, Xin Z, Liu M, Kosogof C, Szczepankiewicz BG, Wang S, Clampit JE, Gum RJ, Haasch DL, Trevillyan JM, Sham HL

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Nov 15; Vol. 16 (22), pp. 5723-30. Date of Electronic Publication: 2006 Sep 12.

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Akademický článek

Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.

Autor: Zhao H; Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-6098, USA. Hongyu.zhao@abbott.com, Serby MD, Xin Z, Szczepankiewicz BG, Liu M, Kosogof C, Liu B, Nelson LT, Johnson EF, Wang S, Pederson T, Gum RJ, Clampit JE, Haasch DL, Abad-Zapatero C, Fry EH, Rondinone C, Trevillyan JM, Sham HL, Liu G

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2006 Jul 27; Vol. 49 (15), pp. 4455-8.

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