Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Haarin Chun"'
Autor:
Svetlana A. Shestopal, Leonid A. Parunov, Philip Olivares, Haarin Chun, Mikhail V. Ovanesov, John R. Pettersson, Andrey G. Sarafanov
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8134 (2022)
Single-chain variable fragments (scFv) are antigen-recognizing variable fragments of antibodies (FV) where both subunits (VL and VH) are connected via an artificial linker. One particular scFv, iKM33, directed against blood coagulation factor VIII (F
Externí odkaz:
https://doaj.org/article/026a20d758e149e5a1412c85d1c496da
Autor:
Haarin Chun, James H. Kurasawa, Philip Olivares, Ekaterina S. Marakasova, Svetlana A. Shestopal, Gabriela U. Hassink, Elena Karnaukhova, Mary Migliorini, Juliet O. Obi, Ally K. Smith, Patrick L. Wintrode, Prasannavenkatesh Durai, Keunwan Park, Daniel Deredge, Dudley K. Strickland, Andrey G. Sarafanov
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:2255-2269
Deficiency in blood coagulation factor VIII (FVIII) results in life-threating bleeding (hemophilia A) treated by infusions of FVIII concentrates. To improve disease treatment, FVIII has been modified to increase its plasma half-life, which requires u
Autor:
Andrey Sarafanov, Leonid Parunov, Philip Olivares, Svetlana Shestopal, John Pettersson, Haarin Chun, Mikhail Ovanesov
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8134
Single-chain variable fragments (scFv) are antigen-recognizing variable fragments of antibodies (FV) where both subunits (VL and VH) are connected via an artificial linker. One particular scFv, iKM33, directed against blood coagulation factor VIII (F
Characterization of protein unable to bind von Willebrand factor in recombinant factor VIII products
Autor:
Philip Olivares, John R Pettersson, Mikhail V Ovanesov, Stepan S Surov, Ekaterina S. Marakasova, Wells W. Wu, Rong-Fong Shen, Andrey G Sarafanov, Haarin Chun, Svetlana A Shestopal
Publikováno v:
Journal of thrombosis and haemostasis : JTHREFERENCES. 19(4)
Background Therapeutic products with coagulation factor VIII (FVIII) have a wide range of specific activities, implying presence of protein with altered structure. Previous studies showed that recombinant FVIII products (rFVIII) contain a fraction (F
Autor:
Shivatheja Soma, Jennifer J. Rahn, Haarin Chun, Alison C. Vicary, Aren Boulet, Jonathan D. Gitlin, Andrew J. Latimer, Byung-Eun Kim, Scot C. Leary, Vishal M. Gohil, Shrishiv A. Timbalia, Sherine S.L. Chan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Inherited pathogenic mutations in genes required for copper delivery to cytochrome c oxidase (CcO) perturb mitochondrial energy metabolism and result in fatal mitochondrial disease. A prior attempt to treat human patients with these muta
Autor:
Mikhail V Ovanesov, John R Pettersson, Rong-Fong Shen, Timothy K Lee, Svetlana A Shestopal, Andrey G Sarafanov, Philip Olivares, Wells W. Wu, Haarin Chun, Stepan S Surov, Ekaterina S. Marakasova
Publikováno v:
Blood. 136:25-26
Introduction Therapeutic products with blood coagulation factor VIII (FVIII) have a wide range of protein contents per activity unit (or IU/mg, specific activity), available from previous studies (Lin et al, 2004; Butenas et al, 2009) and the prescri
Autor:
Svetlana A Shestopal, Andrey G Sarafanov, Ekaterina S. Marakasova, James H. Kurasawa, Haarin Chun, Elena Karnaukhova, Dudley K. Strickland, Nancy E. Hernandez, Philip Olivares, Gabriela U. Hassink
Publikováno v:
The Journal of Biological Chemistry
The low-density lipoprotein receptor (LDLR) family of receptors are cell-surface receptors that internalize numerous ligands and play crucial role in various processes, such as lipoprotein metabolism, hemostasis, fetal development, etc. Previously, r
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports
Scientific Reports
Copper (Cu) is an essential cofactor for various enzymatic activities including mitochondrial electron transport, iron mobilization, and peptide hormone maturation. Consequently, Cu dysregulation is associated with fatal neonatal disease, liver and c
Publikováno v:
Journal of Biological Chemistry. 292:1-14
Copper plays key catalytic and regulatory roles in biochemical processes essential for normal growth, development, and health. Defects in copper metabolism cause Menkes and Wilson's disease, myeloneuropathy, and cardiovascular disease and are associa
Autor:
Dennis R. Winge, Michael J. Petris, Chul-Jin Lee, Tamara Korolnek, Haarin Chun, Byung-Eun Kim, H. Jerome Coyne
Publikováno v:
The Journal of biological chemistry. 294(8)
Zinc is an essential trace element that serves as a cofactor for enzymes in critical biochemical processes and also plays a structural role in numerous proteins. Zinc transporter ZIP4 (ZIP4) is a zinc importer required for dietary zinc uptake in the