Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Haakon B Nygaard"'
Autor:
Khushbu J. Patel, David Yang, John R. Best, Colleen Chambers, Philip E. Lee, Alexandre Henri‐Bhargava, Clark R. Funnell, Dean J. Foti, Jacqueline A. Pettersen, Howard H. Feldman, Haakon B. Nygaard, Ging‐Yuek R. Hsiung, Mari L. DeMarco
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 10, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION In the Investigating the Impact of Alzheimer's Disease Diagnostics in British Columbia (IMPACT‐AD BC) study, we aimed to understand how Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarker testing—used in medical car
Externí odkaz:
https://doaj.org/article/0b3ef9451f9848b3a2c74e5b3e057d1f
Autor:
Khushbu J. Patel, David Yang, Howard H. Feldman, Ging‐Yuek R. Hsiung, Haakon B. Nygaard, John R. Best, Emily Dwosh, Julie M. Robillard, Mari L. DeMarco
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 10, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION We described patients’ and care partners’ experiences with Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarker testing and result disclosure in routine care. METHODS IMPACT‐AD BC is an observational study of clini
Externí odkaz:
https://doaj.org/article/9621bc82cc234204941cd46af4cac87f
Autor:
Christopher Lee, Jonathan Frew, Nicholas L. Weilinger, Stefan Wendt, Wenji Cai, Stefano Sorrentino, Xiujuan Wu, Brian A. MacVicar, Stephanie M. Willerth, Haakon B. Nygaard
Publikováno v:
Neurobiology of Disease, Vol 181, Iss , Pp 106124- (2023)
Frontotemporal dementia (FTD) refers to a group of neurodegenerative disorders that are characterized by pathology predominantly localized to the frontal and temporal lobes. Approximately 40% of FTD cases are familial, and up to 20% of these are caus
Externí odkaz:
https://doaj.org/article/a74313a8c4eb494ab8662323f265613e
Autor:
Manuel Montero-Odasso, G Y Zou, Nellie Kamkar, Howard H. Feldman, Sylvie Belleville, Howard Chertkow, Haakon B Nygaard, Surim Son, Mark Speechley
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-5 (2022)
Abstract Background Multidomain trials to prevent dementia by simultaneously targeting multiple risk factors with non-pharmacological lifestyle interventions show promise. Designing trials to evaluate the efficacy of individual interventions and thei
Externí odkaz:
https://doaj.org/article/17a5e15e47e6440bbcf87ad6e67d5092
Autor:
Stefan Wendt, Sora Johnson, Nicholas L. Weilinger, Christopher Groten, Stefano Sorrentino, Jonathan Frew, Lucy Yang, Hyun B. Choi, Haakon B. Nygaard, Brian A. MacVicar
Publikováno v:
Redox Biology, Vol 56, Iss , Pp 102448- (2022)
The inter-relationship between microglia dynamics and oxidative stress (Ox-stress) in dystrophic neurites (DNs) at Alzheimer’s Disease (AD) plaques may contribute to the pathological changes in neurons. We developed new in vivo imaging strategies t
Externí odkaz:
https://doaj.org/article/7fcc7bbc142e45448ec3f55b2091b1e9
Autor:
Jonathan Frew, Alireza Baradaran-Heravi, Aruna D. Balgi, Xiujuan Wu, Tyler D. Yan, Steve Arns, Fahimeh S. Shidmoossavee, Jason Tan, James B. Jaquith, Karen R. Jansen-West, Francis C. Lynn, Fen-Biao Gao, Leonard Petrucelli, Howard H. Feldman, Ian R. Mackenzie, Michel Roberge, Haakon B. Nygaard
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)
Abstract Background Frontotemporal lobar degeneration (FTLD) is a devastating and progressive disorder, and a common cause of early onset dementia. Progranulin (PGRN) haploinsufficiency due to autosomal dominant mutations in the progranulin gene (GRN
Externí odkaz:
https://doaj.org/article/a734b9c2da774facb813e45baefeeee9
Autor:
Brianne A. Kent, Amelia A. Casciola, Sebastiano K. Carlucci, Meghan Chen, Sam Stager, Maryam S. Mirian, Penelope Slack, Jason Valerio, Martin J. McKeown, Howard H. Feldman, Haakon B. Nygaard
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Sleep disturbances are common in Alzheimer's disease (AD), with estimates of prevalence as high as 65%. Recent work suggests that specific sleep stages, such as slow‐wave sleep (SWS) and rapid eye movement (REM), may directly
Externí odkaz:
https://doaj.org/article/2601cdedc6aa42678bac12f0bf2e23f7
Autor:
Nanxiang Jin, Wilhelmus Drinkenburg, Mihály Hajós, Heikki Tanila, Claudio Babiloni, Haakon B. Nygaard
Publikováno v:
Journal of Alzheimer's Disease. 88:849-865
Recent evidence suggests that about 30%of patients with mild to moderate Alzheimer’s disease (AD) without a known diagnosis of epilepsy may display epileptiform spikes during electroencephalographic (EEG) recordings. These abnormal discharges occur
Autor:
Amelia A. Casciola, Sebastiano K. Carlucci, Brianne A. Kent, Amanda M. Punch, Michael A. Muszynski, Daniel Zhou, Alireza Kazemi, Maryam S. Mirian, Jason Valerio, Martin J. McKeown, Haakon B. Nygaard
Publikováno v:
Sensors, Vol 21, Iss 10, p 3316 (2021)
Sleep disturbances are common in Alzheimer’s disease and other neurodegenerative disorders, and together represent a potential therapeutic target for disease modification. A major barrier for studying sleep in patients with dementia is the requirem
Externí odkaz:
https://doaj.org/article/d8b85c4367cb452b82e60bdf3a1961d9
Autor:
Christian Bocti, Shabbir Amanullah, Robin Hsiung, Howard Chertkow, Howard Feldman, Manuel Montero-Odasso, Haakon B. Nygaard, Andrew Kirk, Kenneth Rockwood, David B. Hogan, Michael Borrie, Sandra E. Black, Morris Freedman, Mario Masellis, Natalie A. Phillips, Louis Verret, Tarek K. Rajji
Publikováno v:
Canadian geriatrics journal : CGJ, vol 24, iss 4
Canadian Geriatrics Journal
Canadian Geriatrics Journal
Alzheimer’s disease is a major cause of morbidity and mortality. Currently, there are no disease-modifying pharmacotherapies for this condition. Aducanumab, an amyloid beta-directed monoclonal antibody that targets aggregated forms of amyloid-beta