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Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire.

Autor: Altman PX; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA., Ozorowski G; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Stanfield RL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Haakenson J; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.; Applied Biomedical Science Institute, San Diego, CA, USA., Appel M; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; International AIDS Vaccine Initiative, New York, NY, USA., Parren M; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Lee WH; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Sang H; Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medical, Kansas State University, Manhattan, Kansas, USA., Woehl J; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; International AIDS Vaccine Initiative, New York, NY, USA., Saye-Francisco K; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Joyce C; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA., Song G; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA., Porter K; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Landais E; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; International AIDS Vaccine Initiative, New York, NY, USA., Andrabi R; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wilson IA; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA., Ward AB; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Mwangi W; Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medical, Kansas State University, Manhattan, Kansas, USA., Smider VV; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.; Applied Biomedical Science Institute, San Diego, CA, USA., Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA, USA., Sok D; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; International AIDS Vaccine Initiative, New York, NY, USA.; Lead contact.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 14. Date of Electronic Publication: 2024 Feb 14.