Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin.

Autor: Couturier C; Evotec, 1541, avenue Marcel Mérieux, 69280, Marcy L'Etoile, France., Groß S; Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy at Saarland University, Campus Building E8.1, 66123, Saarbrücken, Germany., von Tesmar A; Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy at Saarland University, Campus Building E8.1, 66123, Saarbrücken, Germany., Hoffmann J; Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy at Saarland University, Campus Building E8.1, 66123, Saarbrücken, Germany., Deckarm S; Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy at Saarland University, Campus Building E8.1, 66123, Saarbrücken, Germany., Fievet A; Evotec, 40 avenue Tony Garnier, 69007, Lyon, France., Dubarry N; Evotec, 40 avenue Tony Garnier, 69007, Lyon, France., Taillier T; Evotec, 1541, avenue Marcel Mérieux, 69280, Marcy L'Etoile, France., Pöverlein C; Sanofi, 13, Quai Jules Guesde, 94400, Vitry-sur-Seine, France., Stump H; Sanofi, 13, Quai Jules Guesde, 94400, Vitry-sur-Seine, France., Kurz M; Sanofi, 13, Quai Jules Guesde, 94400, Vitry-sur-Seine, France., Toti L; Sanofi, 13, Quai Jules Guesde, 94400, Vitry-sur-Seine, France., Haag Richter S; Sanofi, 13, Quai Jules Guesde, 94400, Vitry-sur-Seine, France., Schummer D; Technische Hochschule Mittelhessen, Wiesenstraße 14, 35390, Gießen, Germany., Sizun P; Sanofi, 13, Quai Jules Guesde, 94400, Vitry-sur-Seine, France., Hoffmann M; Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy at Saarland University, Campus Building E8.1, 66123, Saarbrücken, Germany., Prasad Awal R; Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy at Saarland University, Campus Building E8.1, 66123, Saarbrücken, Germany., Zaburannyi N; Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy at Saarland University, Campus Building E8.1, 66123, Saarbrücken, Germany., Harmrolfs K; Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy at Saarland University, Campus Building E8.1, 66123, Saarbrücken, Germany., Wink J; Mikrobielle Stammsammlung, Helmholtz Centre for Infection Research (HZI), Inhoffenstraße 7, 38124, Braunschweig, Germany., Lessoud E; Evotec, 1541, avenue Marcel Mérieux, 69280, Marcy L'Etoile, France., Vermat T; Evotec, 1541, avenue Marcel Mérieux, 69280, Marcy L'Etoile, France., Cazals V; Evotec, 1541, avenue Marcel Mérieux, 69280, Marcy L'Etoile, France., Silve S; Evotec, 1541, avenue Marcel Mérieux, 69280, Marcy L'Etoile, France., Bauer A; Sanofi, 13, Quai Jules Guesde, 94400, Vitry-sur-Seine, France., Mourez M; Ecole d'Ingénieurs de Purpan, 75 voie du Toec, BP57611, 31076, Toulouse, France., Fraisse L; Drug for Neglected Diseases Initiative, Chemin Camille-Vidart 15, 1202, Geneva, Switzerland., Leroi-Geissler C; Evotec, 1541, avenue Marcel Mérieux, 69280, Marcy L'Etoile, France., Rey A; Charles River Laboratories, 327 impasse du domaine rozier, 69210, Saint-Germain-Nuelles, France., Versluys S; Evotec, 195, route d'Espagne, 31000, Toulouse, France., Bacqué E; Evotec, 1541, avenue Marcel Mérieux, 69280, Marcy L'Etoile, France., Müller R; Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy at Saarland University, Campus Building E8.1, 66123, Saarbrücken, Germany., Renard S; Evotec, 40 avenue Tony Garnier, 69007, Lyon, France.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2022 Dec 19; Vol. 61 (51), pp. e202210747. Date of Electronic Publication: 2022 Nov 21.

Production of the Bengamide Class of Marine Natural Products in Myxobacteria: Biosynthesis and Structure-Activity Relationships.

Autor: Wenzel SC; Helmholtz Institut für Pharmazeutische Forschung Saarland, Helmholtz Zentrum für Infektionsforschung and Universität des Saarlandes, 66123 Saarbrücken (Germany)., Hoffmann H; Sanofi R&D, Industriepark Hoechst, 65926 Frankfurt (Germany).; 13 Quai Jules Guesde, Vitry sur Seine 94403 (France)., Zhang J; Sanofi R&D, Industriepark Hoechst, 65926 Frankfurt (Germany).; 13 Quai Jules Guesde, Vitry sur Seine 94403 (France)., Debussche L; Sanofi R&D, Industriepark Hoechst, 65926 Frankfurt (Germany).; 13 Quai Jules Guesde, Vitry sur Seine 94403 (France)., Haag-Richter S; Sanofi R&D, Industriepark Hoechst, 65926 Frankfurt (Germany).; 13 Quai Jules Guesde, Vitry sur Seine 94403 (France)., Kurz M; Sanofi R&D, Industriepark Hoechst, 65926 Frankfurt (Germany).; 13 Quai Jules Guesde, Vitry sur Seine 94403 (France)., Nardi F; Sanofi R&D, Industriepark Hoechst, 65926 Frankfurt (Germany).; 13 Quai Jules Guesde, Vitry sur Seine 94403 (France)., Lukat P; Helmholtz Institut für Pharmazeutische Forschung Saarland, Helmholtz Zentrum für Infektionsforschung and Universität des Saarlandes, 66123 Saarbrücken (Germany)., Kochems I; Helmholtz Institut für Pharmazeutische Forschung Saarland, Helmholtz Zentrum für Infektionsforschung and Universität des Saarlandes, 66123 Saarbrücken (Germany)., Tietgen H; Sanofi R&D, Industriepark Hoechst, 65926 Frankfurt (Germany).; 13 Quai Jules Guesde, Vitry sur Seine 94403 (France)., Schummer D; TH Mittelhessen, Wiesenstrasse 14, 35390 Gießen (Germany)., Nicolas JP; Sanofi R&D, Industriepark Hoechst, 65926 Frankfurt (Germany).; 13 Quai Jules Guesde, Vitry sur Seine 94403 (France)., Calvet L; Sanofi R&D, Industriepark Hoechst, 65926 Frankfurt (Germany).; 13 Quai Jules Guesde, Vitry sur Seine 94403 (France)., Czepczor V; Sanofi R&D, Industriepark Hoechst, 65926 Frankfurt (Germany).; 13 Quai Jules Guesde, Vitry sur Seine 94403 (France)., Vrignaud P; Sanofi R&D, Industriepark Hoechst, 65926 Frankfurt (Germany).; 13 Quai Jules Guesde, Vitry sur Seine 94403 (France)., Mühlenweg A; Technische Universität Berlin, Str.d.17. Juni 124, 10623 Berlin (Germany)., Pelzer S; Evonik Nutrition & Care, Kantstrasse 2, 33790 Halle (Germany)., Müller R; Helmholtz Institut für Pharmazeutische Forschung Saarland, Helmholtz Zentrum für Infektionsforschung and Universität des Saarlandes, 66123 Saarbrücken (Germany). Rolf.Mueller@helmholtz-hzi.de., Brönstrup M; Helmholtz Zentrum für Infektionsforschung, Inhoffenstrasse 7, 38124 Braunschweig (Germany). Mark.Broenstrup@helmholtz-hzi.de.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2015 Dec 14; Vol. 54 (51), pp. 15560-4. Date of Electronic Publication: 2015 Oct 30.

Marine Compounds for Melanoma Treatment and Prevention.

Autor: Montuori, Eleonora^1,2 (AUTHOR), Capalbo, Anita² (AUTHOR), Lauritano, Chiara² (AUTHOR) chiara.lauritano@szn.it

Publikováno v: International Journal of Molecular Sciences. Sep2022, Vol. 23 Issue 18, pN.PAG-N.PAG. 23p.

Targeted antibiotic discovery through biosynthesis-associated resistance determinants: target directed genome mining.

Autor: O'Neill, Ellis C.¹ (AUTHOR) ellis.oneill@plants.ox.ac.uk, Schorn, Michelle² (AUTHOR), Larson, Charles B.² (AUTHOR), Millán-Aguiñaga, Natalie³ (AUTHOR)

Publikováno v: Critical Reviews in Microbiology. May2019, Vol. 45 Issue 3, p255-277. 23p.

Design, synthesis, and biological evaluation of the novel glycyrrhetinic acid-cinnamoyl hybrids as anti-tumor agents.

Autor: Guo, Wenbo¹ wb_guo@126.com, Yan, Mengmeng¹ yanmengmeng@bucm.edu.cn, Xu, Bing¹ weichenxubing@126.com, Chu, Fuhao¹ chufhao@163.com, Wang, Wei¹ 1005658289@qq.com, Zhang, Chenze¹ zcz920418@163.com, Jia, Xiaohui¹ 18811508865@163.com, Han, Yaotian¹ 20150931935@bucm.edu.cn, Xiang, Hongjun¹ ilovehsq@bucm.edu.cn, Zhang, Yuzhong² zyz100102@126.com, Wang, Penglong¹ wpl581@126.com, Lei, Haimin¹ leihaimin@126.com

Publikováno v: Chemistry Central Journal. 12/1/2016, Vol. 10 Issue 1, p1-11. 11p.