Zobrazeno 1 - 10
of 288
pro vyhledávání: '"Haadsma-Svensson"'
Autor:
Richard S. P. Hsi, Chiu-Hong Lin, Susanne R. Haadsma-Svensson, John A. Easter, Mark J. Ackland, Wayne T. Stolle
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 41:85-85
Autor:
Stolle, Wayne T., Easter, John A., Ackland, Mark J., Haadsma-Svensson, Susanne R., Lin, Chiu-Hong, Hsi, Richard S.P.
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals; January 1998, Vol. 41 Issue: 1 p85-85, 1p
Autor:
Stolle, Wayne T., Easter, John A., Ackland, Mark J., Haadsma‐Svensson, Susanne R., Lin, Chiu‐Hong, Hsi, Richard S.P.
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals; January 1998, Vol. 41 Issue: 1 p85-85, 1p
Autor:
Martin W. Smith, Kjell Svensson, Matt J. Zaya, Susanne R. Haadsma-Svensson, Mary E. Lajiness, Nanette F. Nichols, Chiu-Hong Lin, Rita M. Huff, Christopher L. Haber, Kerry Anne Cleek, J. Neil Duncan, Dac M. Dinh, and Arvid Carlsson
Publikováno v:
Journal of Medicinal Chemistry. 44:4716-4732
5,6-Dimethoxy-2-(N-dipropyl)-aminoindan (3, PNU-99194A) was found to be a selective dopamine D(3) receptor antagonist with potential antipsychotic properties in animal models. To investigate the effects of nitrogen substitution on structure-activity
Autor:
Andrew J. Goudie, E. H F Wong, S. Haadsma-Svensson, A. J. Prus, J. A. Smith, Kjell Svensson, Lisa E. Baker, L. A. Cortes-Burgos
Publikováno v:
Behavioral Pharmacology. 12:303-315
Dopamine D3 receptors have been implicated in the aetiology of schizophrenia and the actions of antipsychotic drugs. The initial studies reported here assessed the involvement of such receptors in the in vivo actions of the atypical antipsychotic clo
Publikováno v:
CNS Drug Reviews. 4:42-53
Autor:
Wayne T. Stolle, Richard S. P. Hsi, Susanne R. Haadsma-Svensson, Chiu-Hong Lin, Mark J. Ackland, John A. Easter
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 39:891-900
The title compound is a potent and selective 5-HT 1A receptor agonist with clinical potentials for treating anxiety and depression. It has been labeled with stable and radioactive isotopes to support ADME studies in animals and human subjects. Its ca
Autor:
Chiu-Hong Lin, Håkan Wikström, Ennis, Stjernlöf P, Nabil B. Ghazal, Kjell A. Svensson, Robert Louis Hoffman, M. W. Smith, Haadsma-Svensson
Publikováno v:
Journal of Medicinal Chemistry, 38(12), 2217-2230. AMER CHEMICAL SOC
A series of analogs of the potent and selective 5-HT1A agonist 8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1-carbaldehyde (2b) (OSU191) was prepared in which the dipropylamino group was modified to bear a variety of substituents. These c
Publikováno v:
Journal of Medicinal Chemistry. 38:725-734
Closely related analogs of the 5-HT 1A receptor agonist cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro-3-propyl-1H-benz[e]indole-9-carboxamide (1, U93385) were synthesized and pharmacologically evaluated. 9-Carboxamide analogs with varied nitrogen substitutio
Autor:
Kjell Svensson, Nicholas Waters, Clas Sonesson, J. Neil Duncan, Arvid Carlsson, H»kan Wikström, M. W. Smith, Chiu-Hong Lin, Susanne R. Haadsma-Svensson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:689-694
A series of (+)-AJ76 and (+)-UH232 analogs with the C-5 methoxy group modified was synthesized and biologically evaluated. Compounds with a triflate or nitrile group were found to be behavioral stimulants with high metabolic stability. The triflate a