Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Ha Nam Nguyen"'
Autor:
Joshua Abbott, Mitali Tambe, Ivan Pavlinov, Atena Farkhondeh, Ha Nam Nguyen, Miao Xu, Manisha Pradhan, Tate York, Matthew Might, Karsten Baumgärtel, Steven Rodems, Wei Zheng
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
NGLY1 deficiency is an ultra-rare, autosomal recessive genetic disease caused by mutations in the NGLY1 gene encoding N-glycanase one that removes N-linked glycan. Patients with pathogenic mutations in NGLY1 have complex clinical symptoms including g
Externí odkaz:
https://doaj.org/article/82f3d9bc8e174166b565226d795f1a90
Autor:
Ivan Pavlinov, Mitali Tambe, Joshua Abbott, Ha Nam Nguyen, Miao Xu, Manisha Pradhan, Atena Farkhondeh, Wei Zheng
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0292926 (2023)
The ability to model human neurological tissues in vitro has been a major hurdle to effective drug development for neurological disorders. iPSC-derived brain organoids have emerged as a compelling solution to this problem as they have the potential t
Externí odkaz:
https://doaj.org/article/a1bde91703554aa0a39e761c681d98d9
Publikováno v:
IEEE Access, Vol 9, Pp 25330-25343 (2021)
Stacking goods or items is one of the most common operations in everyday life. It happens abundantly in not only transportation applications such as container ports, container ships, warehouses, factories, sorting centers, freight terminals, etc., bu
Externí odkaz:
https://doaj.org/article/fc6b4b1c0db44d0a9c5634593848eed9
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 7, Pp 643-652 (2008)
CHFR is an E3 ubiquitin ligase and an early mitotic checkpoint protein implicated in many cancers and in the maintenance of genomic stability. To analyze the role of CHFR in genomic stability, by siRNA, we decreased its expression in genomically stab
Externí odkaz:
https://doaj.org/article/d9d1a9c3d69447f2a0f419d253a94c07
Autor:
Shaohui Hu, Jun Wan, Yijing Su, Qifeng Song, Yaxue Zeng, Ha Nam Nguyen, Jaehoon Shin, Eric Cox, Hee Sool Rho, Crystal Woodard, Shuli Xia, Shuang Liu, Huibin Lyu, Guo-Li Ming, Herschel Wade, Hongjun Song, Jiang Qian, Heng Zhu
Publikováno v:
eLife, Vol 2 (2013)
DNA methylation, especially CpG methylation at promoter regions, has been generally considered as a potent epigenetic modification that prohibits transcription factor (TF) recruitment, resulting in transcription suppression. Here, we used a protein m
Externí odkaz:
https://doaj.org/article/8642ae0b23ca4623ab1a7419c8ee84c6
Autor:
Blake Byers, Branden Cord, Ha Nam Nguyen, Birgitt Schüle, Lief Fenno, Patrick C Lee, Karl Deisseroth, J William Langston, Renee Reijo Pera, Theo D Palmer
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e26159 (2011)
Parkinson's disease (PD) is an incurable age-related neurodegenerative disorder affecting both the central and peripheral nervous systems. Although common, the etiology of PD remains poorly understood. Genetic studies infer that the disease results f
Externí odkaz:
https://doaj.org/article/f72cfe159c57444e95fd1f50c8f5ebf8
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7118 (2009)
BackgroundThe derivation of induced pluripotent stem cells (iPSCs) provides new possibilities for basic research and novel cell-based therapies. Limitations, however, include our current lack of understanding regarding the underlying mechanisms and t
Externí odkaz:
https://doaj.org/article/f1b7c55831e14656a5e3e502525b2462
Autor:
Valina L. Dawson, Guo Li Ming, Kimberly M. Christian, Stephanie J. Temme, Weidong Li, Stephen M. Eacker, Kuei Sen Hsu, Stefan Canzar, Ki Jun Yoon, Francisca Rojas Ringeling, Ted M. Dawson, Ha Nam Nguyen, Bo Xiao, Paul F. Worley, Yu Ting Lin, Namshik Kim, Hongjun Song, Ying Zhou
Publikováno v:
Biological Psychiatry. 92:815-826
Background Gene dosage imbalance caused by copy number variations (CNVs) is a prominent contributor to brain disorders. In particular, 15q11.2 CNV duplications and deletions have been associated with autism spectrum disorder and schizophrenia, respec
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-13 (2022)
Background Circular RNA (circRNA), a class of RNA molecule with a loop structure, has recently attracted researchers due to its diverse biological functions and potential biomarkers of human diseases. Most of the current circRNA detection methods fro
Autor:
Ha-Nam Nguyen, Trung Nghia Vu, Yudi Pawitan, Thi-Hau Nguyen, Dat Thanh Nguyen, Nir Ohad, Quang Thinh Trac
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-18 (2021)
BMC Bioinformatics
BMC Bioinformatics
Background Circular RNA (circRNA) is an emerging class of RNA molecules attracting researchers due to its potential for serving as markers for diagnosis, prognosis, or therapeutic targets of cancer, cardiovascular, and autoimmune diseases. Current me