Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure

Autor: Michael G. Levin, Noah L. Tsao, Pankhuri Singhal, Chang Liu, Ha My T. Vy, Ishan Paranjpe, Joshua D. Backman, Tiffany R. Bellomo, William P. Bone, Kiran J. Biddinger, Qin Hui, Ozan Dikilitas, Benjamin A. Satterfield, Yifan Yang, Michael P. Morley, Yuki Bradford, Megan Burke, Nosheen Reza, Brian Charest, Regeneron Genetics Center, Renae L. Judy, Megan J. Puckelwartz, Hakon Hakonarson, Atlas Khan, Leah C. Kottyan, Iftikhar Kullo, Yuan Luo, Elizabeth M. McNally, Laura J. Rasmussen-Torvik, Sharlene M. Day, Ron Do, Lawrence S. Phillips, Patrick T. Ellinor, Girish N. Nadkarni, Marylyn D. Ritchie, Zoltan Arany, Thomas P. Cappola, Kenneth B. Margulies, Krishna G. Aragam, Christopher M. Haggerty, Jacob Joseph, Yan V. Sun, Benjamin F. Voight, Scott M. Damrauer

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Heart failure is a major cause of cardiovascular morbidity and mortality. Here, the authors report results of a genome-wide association study meta-analysis, characterizing the role of common genetic variants in heart failure, finding overlap with com

Externí odkaz: https://doaj.org/article/2a5c23e2c7b142b5961a518b4d904c75

Molecular Analysis of the Kidney From a Patient With COVID-19–Associated Collapsing Glomerulopathy

Autor: Kristin Meliambro, Xuezhu Li, Fadi Salem, Zhengzi Yi, Zeguo Sun, Lili Chan, Miriam Chung, Jorge Chancay, Ha My T. Vy, Girish Nadkarni, Jenny S. Wong, Jia Fu, Kyung Lee, Weijia Zhang, John C. He, Kirk N. Campbell

Publikováno v: Kidney Medicine, Vol 3, Iss 4, Pp 653-658 (2021)

Recent case reports suggest that coronavirus disease 2019 (COVID-19) is associated with collapsing glomerulopathy in African Americans with apolipoprotein L1 gene (APOL1) risk alleles; however, it is unclear whether disease pathogenesis is similar to

Externí odkaz: https://doaj.org/article/16a9a594ddad44c7b2f31898eee1b372

Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors

Autor: Florian, Thibord, Derek, Klarin, Jennifer A, Brody, Ming-Huei, Chen, Michael G, Levin, Daniel I, Chasman, Ellen L, Goode, Kristian, Hveem, Maris, Teder-Laving, Angel, Martinez-Perez, Dylan, Aïssi, Delphine, Daian-Bacq, Kaoru, Ito, Pradeep, Natarajan, Pamela L, Lutsey, Girish N, Nadkarni, Paul S, de Vries, Gabriel, Cuellar-Partida, Brooke N, Wolford, Jack W, Pattee, Charles, Kooperberg, Sigrid K, Braekkan, Ruifang, Li-Gao, Noemie, Saut, Corriene, Sept, Marine, Germain, Renae L, Judy, Kerri L, Wiggins, Darae, Ko, Christopher J, O'Donnell, Kent D, Taylor, Franco, Giulianini, Mariza, De Andrade, Therese H, Nøst, Anne, Boland, Jean-Philippe, Empana, Satoshi, Koyama, Thomas, Gilliland, Ron, Do, Jennifer E, Huffman, Xin, Wang, Wei, Zhou, Jose, Manuel Soria, Juan, Carlos Souto, Nathan, Pankratz, Jeffery, Haessler, Kristian, Hindberg, Frits R, Rosendaal, Constance, Turman, Robert, Olaso, Rachel L, Kember, Traci M, Bartz, Julie A, Lynch, Susan R, Heckbert, Sebastian M, Armasu, Ben, Brumpton, David M, Smadja, Xavier, Jouven, Issei, Komuro, Katharine R, Clapham, Ruth J F, Loos, Cristen J, Willer, Maria, Sabater-Lleal, James S, Pankow, Alexander P, Reiner, Vania M, Morelli, Paul M, Ridker, Astrid van Hylckama, Vlieg, Jean-François, Deleuze, Peter, Kraft, Daniel J, Rader, Kyung, Min Lee, Bruce M, Psaty, Anne, Heidi Skogholt, Joseph, Emmerich, Pierre, Suchon, Stephen S, Rich, Ha My T, Vy, Weihong, Tang, Rebecca D, Jackson, John-Bjarne, Hansen, Pierre-Emmanuel, Morange, Christopher, Kabrhel, David-Alexandre, Trégouët, Scott M, Damrauer, Andrew D, Johnson, Nicholas L, Smith

Publikováno v: Circulation
Circulation, 2022, 146 (16), ⟨10.1161/CIRCULATIONAHA.122.059675⟩
CIRCULATION
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Background: Venous thromboembolism (VTE) is a life-threatening vascular event with environmental and genetic determinants. Recent VTE genome-wide association studies (GWAS) meta-analyses involved nearly 30 000 VTE cases and identified up to 40 geneti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386371a640cbbdf582ab7affdb48ca95
https://doi.org/10.1161/circulationaha.122.059675

Polygenic prediction of preeclampsia and gestational hypertension

Autor: Michael C. Honigberg, Buu Truong, Raiyan R. Khan, Brenda Xiao, Laxmi Bhatta, Ha My T. Vy, Rafael F. Guerrero, Art Schuermans, Margaret Sunitha Selvaraj, Aniruddh P. Patel, Satoshi Koyama, So Mi Jemma Cho, Shamsudheen Karuthedath Vellarikkal, Mark Trinder, Sarah M. Urbut, Kathryn J. Gray, Ben M. Brumpton, Snehal Patil, Sebastian Zöllner, Mariah C. Antopia, Richa Saxena, Girish N. Nadkarni, Ron Do, Qi Yan, Itsik Pe’er, Shefali Setia Verma, Rajat M. Gupta, David M. Haas, Hilary C. Martin, David A. van Heel, Triin Laisk, Pradeep Natarajan

Publikováno v: Nature Medicine.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b4e3dedb6da4646ec700ae6280ee614
https://doi.org/10.1038/s41591-023-02374-9

Molecular Analysis of the Kidney From a Patient With COVID-19–Associated Collapsing Glomerulopathy

Autor: Jenny Wong, Kristin Meliambro, John Cijiang He, Zhengzi Yi, Lili Chan, Ha My T. Vy, Fadi Salem, Zeguo Sun, Miriam Chung, Girish N. Nadkarni, Kyung Lee, Jia Fu, Weijia Zhang, Xuezhu Li, Jorge Chancay, Kirk N. Campbell

Publikováno v: Kidney Medicine, Vol 3, Iss 4, Pp 653-658 (2021)
Kidney Medicine

Recent case reports suggest that coronavirus disease 2019 (COVID-19) is associated with collapsing glomerulopathy in African Americans with apolipoprotein L1 gene (APOL1) risk alleles; however, it is unclear whether disease pathogenesis is similar to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2a09f06e5e15eb5c3c6053c6b940b1
http://www.sciencedirect.com/science/article/pii/S2590059521000819