Zobrazeno 1 - 10
of 351
pro vyhledávání: '"HYUNG RYONG MOON"'
Autor:
Hee Jin Jung, Hyeon Seo Park, Hye Jin Kim, Hye Soo Park, Yujin Park, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Publikováno v:
Antioxidants, Vol 13, Iss 10, p 1248 (2024)
2-Mercaptomethylbenzo[d]imidazole (2-MMBI) derivatives were designed and synthesized as tyrosinase (TYR) chelators using 2-mercaptomethylimidazole scaffolds. Seven of the ten 2-MMBI derivatives exhibited stronger inhibition of mushroom TYR activity t
Externí odkaz:
https://doaj.org/article/09e7f6b7bc374893b73f581c8cd94b62
Autor:
Hee Jin Jung, Hyeon Seo Park, Hye Soo Park, Hye Jin Kim, Dahye Yoon, Yujin Park, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Publikováno v:
Molecules, Vol 29, Iss 17, p 4162 (2024)
Inspired by the potent tyrosinase inhibitory activity of phenolic compounds with a 2-phenylbenzo[d]thiazole scaffold, we explored phenolic compounds 1–15 with 2-phenylbenzo[d]oxazole, which is isosterically related to 2-phenylbenzo[d]thiazole, as n
Externí odkaz:
https://doaj.org/article/95b92502467c43a78d94d637211f1045
Autor:
Hye Jin Kim, Hee Jin Jung, Young Eun Kim, Daeun Jeong, Hyeon Seo Park, Hye Soo Park, Dongwan Kang, Yujin Park, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Publikováno v:
Molecules, Vol 29, Iss 12, p 2887 (2024)
Based on the fact that substances with a β-phenyl-α,β-unsaturated carbonyl (PUSC) motif confer strong tyrosinase inhibitory activity, benzylidene-3-methyl-2-thioxothiazolidin-4-one (BMTTZD) analogs 1–8 were prepared as potential tyrosinase inhib
Externí odkaz:
https://doaj.org/article/a8658f27ec3a47ee8b42e595485d6097
Autor:
Jae Heun Chung, Ho Jung Choi, Yong Jung Kang, Yun Seong Kim, Sang-Yull Lee, Ryuk Jun Kwon, Han-Sol Jeong, Su-Jung Park, Yeongmu Jeong, Dongwan Kang, Jeongin Ko, SangGyun Noh, Hae Young Chung, Hyung Ryong Moon, Seong Hoon Yoon
Publikováno v:
Experimental Hematology & Oncology, Vol 11, Iss 1, Pp 1-12 (2022)
Abstract Background The protein kinase A (PKA)/cAMP response element-binding protein (CREB) has been suggested to be related to the inhibition of the proliferation of non-small cell lung cancer (NSCLC) cells. This study aimed to investigate the effic
Externí odkaz:
https://doaj.org/article/a199f05f9eec470bbb79bf94c554eaad
Autor:
Heejeong Choi, Il Young Ryu, Inkyu Choi, Sultan Ullah, Hee Jin Jung, Yujin Park, YeJi Hwang, Yeongmu Jeong, Sojeong Hong, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 899-912 (2022)
As part of our continuous search for novel tyrosinase inhibitors, we designed 5,6-dihydroimindazo[2,1-b]thiazol-3(2H)-one (DHIT) derivatives based on the structure of MHY773; a potent tyrosinase inhibitor with a 2-iminothiazolidin-4-one template. Of
Externí odkaz:
https://doaj.org/article/a5e454fd81fe488cbb1512c293b5c205
Autor:
Jeongwon Kim, Jieun Lee, Dahye Yoon, Minjung Son, Mi-Jeong Kim, Sugyeong Ha, Doyeon Kim, Ji-an Yoo, Donghwan Kim, Hae Young Chung, Hyung Ryong Moon, Ki Wung Chung
Publikováno v:
Antioxidants, Vol 12, Iss 11, p 1947 (2023)
Chronic kidney disease (CKD) is a kidney structure and function abnormality. CKD development and progression are strongly influenced by oxidative stress and inflammatory responses, which can lead to tubulointerstitial fibrosis. Unfortunately, there a
Externí odkaz:
https://doaj.org/article/c2104f4e5bd74a75aa70f8887fa9d6eb
Autor:
Jieun Lee, Hye Soo Park, Hee Jin Jung, Yu Jung Park, Min Kyung Kang, Hye Jin Kim, Dahye Yoon, Sultan Ullah, Dongwan Kang, Yujin Park, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Publikováno v:
Antioxidants, Vol 12, Iss 10, p 1814 (2023)
Ten 2-mercaptobenzimidazole (2-MBI) analogs were synthesized as potential tyrosinase inhibitors because mercapto-containing compounds can bind to copper ions at the active site of tyrosinase to inhibit enzyme activity. Nine 2-MBI analogs showed sub-m
Externí odkaz:
https://doaj.org/article/18f948aa94fc4854b9bbd821818257a9
Publikováno v:
Antibiotics, Vol 12, Iss 5, p 853 (2023)
Two synthetic compounds, MHY1383, azo-resveratrol and MHY1387, 5-[4-hydroxy-3,5-methoxybenzy]-2-thioxodihydropyrimidine-4,6[1H,5H]-dione have been reported to have an anti-biofilm effect on Pseudomonas aeruginosa at very low concentrations (1–10 pM
Externí odkaz:
https://doaj.org/article/fe26db18bb764dc18b4676abdad35d86
Autor:
Inkyu Choi, Yujin Park, Il Young Ryu, Hee Jin Jung, Sultan Ullah, Heejeong Choi, Chaeun Park, Dongwan Kang, Sanggwon Lee, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 37-50 (2021)
The β-phenyl-α,β-unsaturated carbonyl (PUSC) scaffold confers tyrosinase inhibitory activity, and in the present study, 16 (Z)-5-(substituted benzylidene)-3-phenyl-2-thioxooxazolidin-4-one analogues containing this scaffold were synthesized. Mushr
Externí odkaz:
https://doaj.org/article/89ae3e87421146fd846ffb9e9870e0f5
Autor:
Dahye Yoon, Min Kyung Kang, Hee Jin Jung, Sultan Ullah, Jieun Lee, Yeongmu Jeong, Sang Gyun Noh, Dongwan Kang, Yujin Park, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Publikováno v:
Molecules, Vol 28, Iss 8, p 3293 (2023)
(Z)-5-Benzylidene-2-phenylthiazol-4(5H)-one ((Z)-BPT) derivatives were designed by combining the structural characteristics of two tyrosinase inhibitors. The double-bond geometry of trisubstituted alkenes, (Z)-BPTs 1–14, was determined based on the
Externí odkaz:
https://doaj.org/article/83de3ac4d88c40939741c8536066e95e