Zobrazeno 1 - 10
of 6 841
pro vyhledávání: '"HYPOMETHYLATION"'
Autor:
Junjie Zhao, Xiuyi Pan, Zilin Wang, Yuntian Chen, Dingbang Liu, Yu Shen, Xinyuan Wei, Chenhao Xu, Xingming Zhang, Xu Hu, Junru Chen, Jinge Zhao, Bo Tang, Guangxi Sun, Pengfei Shen, Zhenhua Liu, Hao Zeng, Jiayu Liang
Publikováno v:
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-19 (2024)
Abstract Background A substantial proportion of patients with metastatic clear cell renal cell carcinoma (ccRCC) cannot derive benefit from immune checkpoint inhibitor (ICI) plus anti-angiogenic agent combination therapy, making identification of pre
Externí odkaz:
https://doaj.org/article/ef7222936c4e46d2af55356092940bf1
Autor:
Renan da Silva Santos, Daniel Pascoalino Pinheiro, Carlos Gustavo Hirth, Maria Júlia Barbosa Bezerra, Isabelle Joyce de Lima Silva-Fernandes, Francisca Andréa da Silva Oliveira, Maisa Viana de Holanda Barros, Ester Silveira Ramos, Arlindo A. Moura, Manoel Odorico de Moraes Filho, Claudia Pessoa, Cristiana Libardi Miranda Furtado
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
ABSTRACTPenile squamous cell carcinoma (SCC) is a rare and aggressive tumour mainly related to lifestyle behaviour and human papillomavirus (HPV) infection. Environmentally induced loss of imprinting (LOI) at the H19 differentially methylated region
Externí odkaz:
https://doaj.org/article/f061f9d4003345e9ba09a617978bc176
Autor:
Danyang Li, Yigang Yuan, Chen Meng, Zihan Lin, Min Zhao, Liuzhi Shi, Min Li, Daijiao Ye, Yue Cai, Xiaofei He, Haige Ye, Shujuan Zhou, Haixia Zhou, Shenmeng Gao
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background miR-182 promoter hypermethylation frequently occurs in various tumors, including acute myeloid leukemia, and leads to low expression of miR-182. However, whether adult acute lymphocyte leukemia (ALL) cells have high miR-182 promot
Externí odkaz:
https://doaj.org/article/c44c05750ee741bc967316cdfdac82e9
Autor:
Mio Harachi, Kenta Masui, Erika Shimizu, Kumiko Murakami, Hiromi Onizuka, Yoshihiro Muragaki, Takakazu Kawamata, Hisako Nakayama, Mariko Miyata, Takashi Komori, Webster K. Cavenee, Paul S. Mischel, Atsushi Kurata, Noriyuki Shibata
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract DNA methylation is crucial for chromatin structure and gene expression and its aberrancies, including the global “hypomethylator phenotype”, are associated with cancer. Here we show that an underlying mechanism for this phenotype in the
Externí odkaz:
https://doaj.org/article/59ba976a12834ee782df85c5cc6333ba
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/be6a68d8894f4384b20a06c47a2862c8
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 277, Iss , Pp 116351- (2024)
The increasing concentration of Antimony (Sb) in ecological environments has raised serious concerns about its potential biotoxicological impact. This study investigated the toxicokinetics, Global DNA Methylation (GDM), biomarker expression, and Inte
Externí odkaz:
https://doaj.org/article/4fb6a2446fe344b39241ce041f2801d1
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract Background Establishment of DNA methylation (DNAme) patterns is essential for balanced multi-lineage cellular differentiation, but exactly how these patterns drive cellular phenotypes is unclear. While > 80% of CpG sites are stably methylate
Externí odkaz:
https://doaj.org/article/8465ab5e610b4941a3e2b0a0610e8ae5
Autor:
Xianwei Wang, Lu Liu, Xiaohua Jiang, Jason Saredy, Hang Xi, Ramon Cueto, Danni Sigler, Mohsin Khan, Sheng Wu, Yong Ji, Nathaniel W. Snyder, Wenhui Hu, Xiaofeng Yang, Hong Wang
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-17 (2023)
Abstract Background Hyperhomocysteinemia (HHcy) has been linked to development of Alzheimer’s disease (AD) neuropathologically characterized by the accumulation of amyloid β (Aβ). Microglia (MG) play a crucial role in uptake of Aβ fibrils, and i
Externí odkaz:
https://doaj.org/article/2f25920bcdce4d459ea752eb0ce81137
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