Výsledky vyhledávání

Intrathymic immune modulation prevents acute rejection but not the development of graft arteriosclerosis (chronic rejection)

Autor: Hillebrands, JL, Raue, HP, Klatter, FA, Hylkema, MN, Platteel, I., Hardonk-Wubbena, A, Nieuwenhuis, P, Rozing, J

Publikováno v: Transplantation, 71(7), 914-924. LIPPINCOTT WILLIAMS & WILKINS

Background. We showed previously that our intrathymic immune modulation protocol induces virtually permanent graft survival of simultaneously transplanted cardiac allografts in MHC-incompatible rat strain combinations. It is, however, unknown whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::320ed1bb707bfba9f0096e5cfeae460f
https://research.rug.nl/en/publications/2205ebdb-905d-4756-b5a4-f532cc8cca3d

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Histone-containing immune complexes are to a large extent responsible for anti-dsDNA reactivity in the Farr assay of active SLE patients

Autor: Hylkema, MN, van Bruggen, MCJ, ten Hove, T, de Jong, J, Swaak, AJG, Berden, JHM, Smeenk, RJT

Publikováno v: Journal of Autoimmunity, 14(2), 159-168. ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD

Increased titres of anti-dsDNA antibodies, especially if of high avidity, are associated with renal exacerbations in patients with systemic lupus erythematosus (SLE). One of the most reliable assays to measure anti-dsDNA antibodies, the Farr assay, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::1388386d0992bf2a1dc9c1e4c6503474
https://research.rug.nl/en/publications/24b180ee-a5f5-4e3c-8acb-acb891a0a0c1

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In vivo ANA is a fixation artifact: Nucleosome-complexed antinucleosome autoantibodies bind to the cell surface and are internalized

Autor: Kramers, K, vanBruggen, MCJ, RijkeSchilder, TPM, Dijkman, Henry B P M, Hylkema, MN, Croes, HJE, Fransen, JAM, Assmann, KJM, Tax, WJM, Smeenk, RJT, Berden, JHM

Publikováno v: Journal of the American Society of Nephrology, 7(6), 946-954. AMER SOC NEPHROLOGY

It has been suggested that binding of anti-double-stranded DNA antibodies to cell surfaces, followed by internalization and nuclear binding (so called in vivo ANA) is of pathophysiological significance for tissue damage in systemic lupus erythematosu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::0ceaaed664c9696324f799fa9377007f
https://research.rug.nl/en/publications/77c52e6a-e40f-43e4-a35a-9cb437875221

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NO EVIDENCE FOR AN INDEPENDENT ROLE OF ANTI-HEPARAN SULFATE REACTIVITY APART FROM ANTI-DNA IN LUPUS NEPHRITIS

Autor: HYLKEMA, MN, ZWET, IVD, KRAMERS, C, VANBRUGGEN, MCJ, SWAAK, AJG, BERDEN, JHM, SMEENK, RJT, Hylkema, Machteld

Publikováno v: Clinical and Experimental Immunology, 101(1), 55-59. Wiley

The presence of anti-heparan sulphate (HS) reactivity in serum is closely related to the occurrence of nephritis in patients with systemic lupus erythematosus (SLE). Since patients with lupus nephritis in general also have high titres of anti-DNA ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::d50fc677d3fda75b83cdff4388a478bc
https://research.rug.nl/en/publications/a10420e9-7d52-40f5-bb67-dcc6a08e7875

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PATHOPHYSIOLOGY OF LUPUS NEPHRITIS: THE ROLE OF NUCLEOSOMES

Autor: VANBRUGGEN, MCJ, KRAMERS, C, HYLKEMA, MN, SMEENK, RJT, BERDEN, JHM, Hylkema, Machteld

Publikováno v: The Netherlands Journal of Medicine, 45(6), 273-279. van Zuiden Communications BV.

Lupus nephritis is regarded as an immune complex mediated disease. Since anti-DNA antibodies are present in the circulation and in diseased glomeruli of patients with lupus nephritis, these antibodies have been assigned a pivotal role in the initiati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::8ab8a447cdc1351e3e079e364f656b71
https://research.rug.nl/en/publications/a411674d-c84c-4239-bd8a-6bb322fac014

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A NEW ELISA FOR THE DETECTION OF ANTI-HEPARAN SULFATE REACTIVITY, USING PHOTOBIOTINYLATED ANTIGEN

Autor: HYLKEMA, MN, KRAMERS, C, VANDERWAL, TJ, VANBRUGGEN, MCJ, SWAAK, AJG, BERDEN, JHM, SMEENK, RJT, Hylkema, Machteld

Publikováno v: Journal of Immunological Methods, 176(1), 33-43. ELSEVIER SCIENCE BV

Autoantibodies reacting with a great variety of autoantigens are characteristic for the autoimmune disease systemic lupus erythematosus (SLE). Although reactivity with heparan sulfate (HS) in sera of patients with SLE is found in association with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::b8832504ccd58ea06ba09f0c148615a0
https://research.rug.nl/en/publications/d5d10eb0-228c-47bb-a980-53fc3eac5a76

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ANTI-NUCLEOSOME ANTIBODIES COMPLEXED TO NUCLEOSOMAL ANTIGENS SHOW ANTI-DNA REACTIVITY AND BIND TO RAT GLOMERULAR-BASEMENT-MEMBRANE IN-VIVO

Autor: KRAMERS, C, HYLKEMA, MN, VANBRUGGEN, MCJ, VANDELAGEMAAT, R, DIJKMAN, HBPM, ASSMANN, KJM, SMEENK, RJT, BERDEN, JHM, Hylkema, Machteld

Publikováno v: CLIN Journal, 94(2), 568-577. AMER SOC CLINICAL INVESTIGATION INC

Histones can mediate the binding of DNA and anti-DNA to the glomerular basement membrane (GBM). Zn ELISA histone/DNA/anti-DNA complexes are able to bind to heparan sulfate (HS), an intrinsic constituent of the GBM. We questioned whether histone conta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::e8661d1d9a8ebaa9738fb0102b715d7c
https://research.rug.nl/en/publications/e79a398d-a51a-405b-83b9-241ea55e7e16

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