Zobrazeno 1 - 10
of 93
pro vyhledávání: '"HYE LIM NOH"'
Autor:
Randall H. Friedline, Hye Lim Noh, Sujin Suk, Mahaa Albusharif, Sezin Dagdeviren, Suchaorn Saengnipanthkul, Bukyung Kim, Allison M. Kim, Lauren H. Kim, Lauren A. Tauer, Natalie M. Baez Torres, Stephanie Choi, Bo-Yeon Kim, Suryateja D. Rao, Kaushal Kasina, Cheng Sun, Benjamin J. Toles, Chan Zhou, Zixiu Li, Vivian M. Benoit, Payal R. Patel, Doris X. T. Zheng, Kunikazu Inashima, Annika Beaverson, Xiaodi Hu, Duy A. Tran, Werner Muller, Dale L. Greiner, Alan C. Mullen, Ki Won Lee, Jason K. Kim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Obesity is a major cause of metabolic dysfunction-associated steatohepatitis (MASH) and is characterized by inflammation and insulin resistance. Interferon-γ (IFNγ) is a pro-inflammatory cytokine elevated in obesity and modulating macropha
Externí odkaz:
https://doaj.org/article/8e5cb5e93c2e43288feb95e635cd27f8
Autor:
Randall H. Friedline, Hye Lim Noh, Sujin Suk, Mahaa Albusharif, Sezin Dagdeviren, Suchaorn Saengnipanthkul, Bukyung Kim, Allison M. Kim, Lauren H. Kim, Lauren A. Tauer, Natalie M. Baez Torres, Stephanie Choi, Bo-Yeon Kim, Suryateja D. Rao, Kaushal Kasina, Cheng Sun, Benjamin J. Toles, Chan Zhou, Zixiu Li, Vivian M. Benoit, Payal R. Patel, Doris X. T. Zheng, Kunikazu Inashima, Annika Beaverson, Xiaodi Hu, Duy A. Tran, Werner Muller, Dale L. Greiner, Alan C. Mullen, Ki Won Lee, Jason K. Kim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/4fd7ed9712ca43fbbfea0936d917d2b4
Autor:
Søs Skovsø, Evgeniy Panzhinskiy, Jelena Kolic, Haoning Howard Cen, Derek A. Dionne, Xiao-Qing Dai, Rohit B. Sharma, Lynda Elghazi, Cara E. Ellis, Katharine Faulkner, Stephanie A. M. Marcil, Peter Overby, Nilou Noursadeghi, Daria Hutchinson, Xiaoke Hu, Hong Li, Honey Modi, Jennifer S. Wildi, J. Diego Botezelli, Hye Lim Noh, Sujin Suk, Brian Gablaski, Austin Bautista, Ryekjang Kim, Corentin Cras-Méneur, Stephane Flibotte, Sunita Sinha, Dan S. Luciani, Corey Nislow, Elizabeth J. Rideout, Eric N. Cytrynbaum, Jason K. Kim, Ernesto Bernal-Mizrachi, Laura C. Alonso, Patrick E. MacDonald, James D. Johnson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Insulin receptor protein is present in pancreatic β-cells, but the consequences of β-cell insulin resistance are incompletely understood. Here the authors use a combination of mouse studies and mathematical modelling to show that loss of beta-cell
Externí odkaz:
https://doaj.org/article/34fcff15f65143fa8ca0bab84b4cd93e
Autor:
Suchaorn Saengnipanthkul, Hye Lim Noh, Randall H. Friedline, Sujin Suk, Stephanie Choi, Nicholas K. Acosta, Duy A. Tran, Xiaodi Hu, Kunikazu Inashima, Allison M. Kim, Ki Won Lee, Jason K. Kim
Publikováno v:
Physiological Reports, Vol 9, Iss 6, Pp n/a-n/a (2021)
Abstract Increasing evidence shows a potential link between the perinatal nutrient environment and metabolic outcome in offspring. Here, we investigated the effects of maternal feeding of a high‐fat diet (HFD) during the perinatal period on hepatic
Externí odkaz:
https://doaj.org/article/7e3e901846094972a3f3f8a6e838bb42
Autor:
Martina Chrudinová, François Moreau, Hye Lim Noh, Terezie Páníková, Lenka Žáková, Randall H. Friedline, Francisco A. Valenzuela, Jason K. Kim, Jiří Jiráček, C. Ronald Kahn, Emrah Altindis
Publikováno v:
Molecular Metabolism, Vol 44, Iss , Pp 101121- (2021)
Objective: Members of the insulin/insulin-like growth factor (IGF) superfamily are well conserved across the evolutionary tree. We recently showed that four viruses in the Iridoviridae family possess genes that encode proteins highly homologous to hu
Externí odkaz:
https://doaj.org/article/6021b0b3fea045b7b555497608ce50e0
Autor:
Anu Shah, Sezin Dagdeviren, Jordan P. Lewandowski, Angela B. Schmider, Elisabeth M. Ricci-Blair, Niranjana Natarajan, Henna Hundal, Hye Lim Noh, Randall H. Friedline, Charles Vidoudez, Jason K. Kim, Amy J. Wagers, Roy J. Soberman, Richard T. Lee
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101521- (2020)
Summary: Increased consumption of fats and added sugars has been associated with an increase in metabolic syndromes. Here we show that mice chronically fed an energy-rich diet (ERD) with high fat and moderate sucrose have enhanced the absorption of a
Externí odkaz:
https://doaj.org/article/24e910ae67174beba18cf61e73cb6974
Autor:
Carmen Hurtado del Pozo, Henry H. Ruiz, Lakshmi Arivazhagan, Juan Francisco Aranda, Cynthia Shim, Peter Daya, Julia Derk, Michael MacLean, Meilun He, Laura Frye, Randall H. Friedline, Hye Lim Noh, Jason K. Kim, Richard A. Friedman, Ravichandran Ramasamy, Ann Marie Schmidt
Publikováno v:
Cell Reports, Vol 28, Iss 3, Pp 773-791.e7 (2019)
Summary: Exquisite regulation of energy homeostasis protects from nutrient deprivation but causes metabolic dysfunction upon nutrient excess. In human and murine adipose tissue, the accumulation of ligands of the receptor for advanced glycation end p
Externí odkaz:
https://doaj.org/article/9cda9d74ebcc4ce59e138adbf8231d62
Autor:
Ozlem Senol-Cosar, Rachel J. Roth Flach, Marina DiStefano, Anil Chawla, Sarah Nicoloro, Juerg Straubhaar, Olga T. Hardy, Hye Lim Noh, Jason K. Kim, Martin Wabitsch, Philipp E. Scherer, Michael P. Czech
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Expansion of visceral adipose tissue is usually associated with insulin resistance and metabolic disease. Here, the authors show that the membrane protein TNMD is upregulated in visceral fat of insulin resistant obese individuals and promotes healthy
Externí odkaz:
https://doaj.org/article/2b8301dcb67b41eabe00ec0fa2a01c48
Autor:
David J. Pedersen, Adilson Guilherme, Laura V. Danai, Lauren Heyda, Anouch Matevossian, Jessica Cohen, Sarah M. Nicoloro, Juerg Straubhaar, Hye Lim Noh, DaeYoung Jung, Jason K. Kim, Michael P. Czech
Publikováno v:
Molecular Metabolism, Vol 4, Iss 7, Pp 507-518 (2015)
Objective: Adipose tissue (AT) inflammation is associated with systemic insulin resistance and hyperinsulinemia in obese rodents and humans. A longstanding concept is that hyperinsulinemia may promote systemic insulin resistance through downregulatio
Externí odkaz:
https://doaj.org/article/25dbea29984f42b69a63ebc38311b475
Autor:
RANDALL H. FRIEDLINE, MAHAA ALBUSHARIF, HYE LIM NOH, ALLISON M. KIM, LAUREN H. KIM, DORIS X.T. ZHENG, GLENNA SWINAND, ANNIKA BEAVERSON, XIAODI HU, LAUREN A. TAUER, WERNER MULLER, JASON K. KIM
Publikováno v:
Diabetes. 71
Nonalcoholic steatohepatitis (NASH) is a major complication of obesity, and interferon-γ (IFNγ) is a key regulator of innate and adaptive immunity by priming macrophages and inducing an inflammatory response. We have recently generated mice with co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6629d290dfddeccef169683dd3a87fb1
https://doi.org/10.2337/db22-270-or
https://doi.org/10.2337/db22-270-or