Old neurochemical markers, new functional directions?

Autor: Philippe De Deurwaerdère, Roxanne A. Vaughan, Silvana Gaetani

Publikováno v: Journal of Neurochemistry. 152:623-626

The dorsal striatum coordinates input-output processing of numerous functions including those related to motor activity, motivation, and learning. Considerable anatomical and biochemical heterogeneity across striatal subregions has long been known to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5490db6766d8d0d52958e3e9cdc5df8d
https://doi.org/10.1111/jnc.14929

Small-molecule control of neurotransmitter sulfonation

Autor: Alexander Deiters, Thomas S. Leyh, Ting Wang, Kristie Darrah, Ian Cook, Mary Cacace

Publikováno v: The Journal of Biological Chemistry

Controlling unmodified serotonin levels in brain synapses is a primary objective when treating major depressive disorder - a disease that afflicts ~20% of the world's population. Roughly 60% of patients respond poorly to first-line treatments and thu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cad720d003b48d451231b4b31986a0c
http://europepmc.org/articles/PMC7948405

Disruption of the PDZ domain–binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation

Autor: Matthew D. Lycas, Pia Weikop, Mattias Rickhag, Gitta Wörtwein, Raul R. Gainetdinov, Gunnar Sørensen, Damiana Leo, Jamila H. Lilja, Pedro Rifes, Pernille Herrstedt Ridderstrøm, Ulrik Gether, Freja Herborg, Anders Fink-Jensen, David P.D. Woldbye

Publikováno v: Sørensen, G, Rickhag, M, Leo, D, Lycas, M D, Ridderstrøm, P H, Weikop, P, Lilja, J H, Rifes, P, Herborg, F, Woldbye, D, Wörtwein, G, Gainetdinov, R R, Fink-Jensen, A & Gether, U 2021, ' Disruption of the PDZ domain-binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation ', Journal of Biological Chemistry, vol. 297, no. 6, 101361 . https://doi.org/10.1016/j.jbc.2021.101361
The Journal of Biological Chemistry

The dopamine transporter (DAT) is part of a presynaptic multi-protein network involving interactions with scaffold proteins via its C-terminal PDZ-domain binding sequence. Using a mouse model expressing DAT with mutated PDZ binding sequence (DAT-AAA)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80451722f31d9f39c558cfd764ce7d5
https://doi.org/10.1016/j.jbc.2021.101361

Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue

Autor: F. Wieske, Nafisa M. Jadavji, C. Winter, Ulrich Dirnagl

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 3, Iss C, Pp 1-4 (2015)
Molecular genetics and metabolism reports 3, 1-4 (2015). doi:10.1016/j.ymgmr.2015.02.001
Molecular Genetics and Metabolism Reports

Methylenetetrahydrofolate reductase (MTHFR) is an enzyme key regulator in folate metabolism. Deficiencies in MTHFR result in increased levels of homocysteine, which leads to reduced levels of S-adenosylmethionine (SAM). In the brain, SAM donates meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f94e7d17647012aafbfc0b8cbcedf8
http://www.sciencedirect.com/science/article/pii/S2214426915000087

Paraquat and psychological stressor interactions as pertains to Parkinsonian co-morbidity

Autor: Shuaib Syed, Darcy Litteljohn, Zach Dwyer, Shawn Hayley, Chris Rudyk

Publikováno v: Neurobiology of Stress
Neurobiology of Stress, Vol 2, Iss C, Pp 85-93 (2015)

A number of epidemiological and experimental studies have implicated the non-selective herbicide, paraquat, in the development of sporadic Parkinson's disease (PD). While preclinical research has focused mainly on elucidating the nigrostriatal effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efae7e078d61712e2d5a010f22bf0587
https://doi.org/10.1016/j.ynstr.2015.09.001