Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions

Autor: Dareng, Eileen O. ^{2, 141}, Coetzee, Simon G. ^{1, 141}, Tyrer, Jonathan P. ^{4, 141}, Peng, Pei-Chen ^{1, 141}, Rosenow, Will ^{3, 141}, Chen, Stephanie ^{1, 5}, Davis, Brian D. ^{1, 5}, Dezem, Felipe Segato ¹, Seo, Ji-Heui ^{6, 7}, Nameki, Robbin ^{8, 9}, Reyes, Alberto L. ¹, Aben, Katja K.H. ^{10, 11}, Anton-Culver, Hoda ¹², Antonenkova, Natalia N. ¹³, Aravantinos, Gerasimos ¹⁴, Bandera, Elisa V. ¹⁵, Beane Freeman, Laura E. ¹⁶, Beckmann, Matthias W. ¹⁷, Beeghly-Fadiel, Alicia ¹⁸, Benitez, Javier ^{19, 20}, Bernardini, Marcus Q. ²¹, Bjorge, Line ^{22, 23}, Black, Amanda ²⁴, Bogdanova, Natalia V. ^{13, 25, 26}, Bolton, Kelly L. ²⁷, Brenton, James D. ²⁸, Budzilowska, Agnieszka ²⁹, Butzow, Ralf ³⁰, Cai, Hui ¹⁸, Campbell, Ian ^{31, 32}, Cannioto, Rikki ³³, Chang-Claude, Jenny ^{34, 35}, Chanock, Stephen J. ¹⁶, Chen, Kexin ³⁶, Chenevix-Trench, Georgia ³⁷, Chiew, Yoke-Eng ^{38, 39}, Cook, Linda S. ^{40, 41}, DeFazio, Anna ^{38, 39, 42}, Dennis, Joe ², Doherty, Jennifer A. ⁴³, Dörk, Thilo ²⁶, du Bois, Andreas ^{44, 45}, Dürst, Matthias ⁴⁶, Eccles, Diana M. ⁴⁷, Ene, Gabrielle ²¹, Fasching, Peter A. ¹⁷, Flanagan, James M. ⁴⁸, Fortner, Renée T. ³⁴, Fostira, Florentia ⁴⁹, Gentry-Maharaj, Aleksandra ⁵⁰, Giles, Graham G. ^{51, 52, 53}, Goodman, Marc T. ⁵⁴, Gronwald, Jacek ⁵⁵, Haiman, Christopher A. ⁵⁶, Håkansson, Niclas ⁵⁷, Heitz, Florian ^{44, 45, 58}, Hildebrandt, Michelle A.T. ⁵⁹, Høgdall, Estrid ⁶⁰, Høgdall, Claus K. ⁶¹, Huang, Ruea-Yea ⁶², Jensen, Allan ⁶³, Jones, Michael E. ⁶⁴, Kang, Daehee ^{65, 66}, Karlan, Beth Y. ⁶⁷, Karnezis, Anthony N. ⁶⁸, Kelemen, Linda E. ⁶⁹, Kennedy, Catherine J. ^{38, 39, 70}, Khusnutdinova, Elza K. ^{71, 72}, Kiemeney, Lambertus A. ¹⁰, Kjaer, Susanne K. ^{61, 63}, Kupryjanczyk, Jolanta ²⁹, Labrie, Marilyne ⁷³, Lambrechts, Diether ^{74, 75}, Larson, Melissa C. ⁷⁶, Le, Nhu D. ⁷⁷, Lester, Jenny ⁶⁷, Li, Lian ³⁶, Lubiński, Jan ⁵⁵, Lush, Michael ², Marks, Jeffrey R. ⁷⁸, Matsuo, Keitaro ^{79, 80}, May, Taymaa ²¹, McLaughlin, John R. ⁸¹, McNeish, Iain A. ^{82, 83}, Menon, Usha ⁵⁰, Missmer, Stacey ^{84, 85, 86}, Modugno, Francesmary ^{87, 88}, Moffitt, Melissa ⁸⁹, Monteiro, Alvaro N. ⁹⁰, Moysich, Kirsten B. ⁹¹, Narod, Steven A. ⁹², Nguyen-Dumont, Tu ^{53, 93}, Odunsi, Kunle ^{94, 95}, Olsson, Håkan ⁹⁶, Onland-Moret, N. Charlotte ⁹⁷, Park, Sue K. ^{65, 66, 98}, Pejovic, Tanja ^{99, 100}, Permuth, Jennifer B. ⁹⁰, Piskorz, Anna ²⁸, Prokofyeva, Darya ⁷², Riggan, Marjorie J. ¹⁰¹, Risch, Harvey A. ¹⁰², Rodríguez-Antona, Cristina ^{20, 103}, Rossing, Mary Anne ^{104, 105}, Sandler, Dale P. ¹⁰⁶, Setiawan, V. Wendy ⁵⁶, Shan, Kang ¹⁰⁷, Song, Honglin ¹⁰⁸, Southey, Melissa C. ^{51, 53, 93}, Steed, Helen ^{109, 110}, Sutphen, Rebecca ¹¹¹, Swerdlow, Anthony J. ^{64, 112}, Teo, Soo Hwang ^{113, 114}, Terry, Kathryn L. ^{86, 115}, Thompson, Pamela J. ¹¹⁶, Vestrheim Thomsen, Liv Cecilie ^{22, 23}, Titus, Linda ¹¹⁷, Trabert, Britton ²⁴, Travis, Ruth ¹¹⁸, Tworoger, Shelley S. ⁹⁰, Valen, Ellen ^{22, 23}, Van Nieuwenhuysen, Els ¹¹⁹, Edwards, Digna Velez ¹²⁰, Vierkant, Robert A. ⁷⁶, Webb, Penelope M. ¹²¹, Weinberg, Clarice R. ¹²², Weise, Rayna Matsuno ¹²³, Wentzensen, Nicolas ²⁴, White, Emily ^{105, 124}, Winham, Stacey J. ¹²⁵, Wolk, Alicja ^{57, 126}, Woo, Yin-Ling ¹²⁷, Wu, Anna H. ¹²⁸, Yan, Li ¹²⁹, Yannoukakos, Drakoulis ⁴⁹, Zeinomar, Nur ¹⁵, Zheng, Wei ¹⁸, Ziogas, Argyrios ¹², Berchuck, Andrew ¹⁰¹, Goode, Ellen L. ¹³⁰, Huntsman, David G. ^{131, 132}, Pearce, Celeste L. ^{128, 133}, Ramus, Susan J. ^{134, 135}, Sellers, Thomas A. ¹³⁶, Freedman, Matthew L. ^{6, 7}, Lawrenson, Kate ^{8, 9}, Schildkraut, Joellen M. ¹³⁷, Hazelett, Dennis ^{138, 142}, Plummer, Jasmine T. ^{1, 5, 142}, Kar, Siddhartha ^{139, 140, 142}, Jones, Michelle R. ^{1, 142}, Pharoah, Paul D.P. ^{2, 4, 142, ∗}, Gayther, Simon A. ^{1, 142, ∗∗}

Publikováno v: In The American Journal of Human Genetics 6 June 2024 111(6):1061-1083

Classification of Epithelial Ovarian Carcinoma Whole-Slide Pathology Images Using Deep Transfer Learning

Autor: Wang, Yiping, Farnell, David, Farahani, Hossein, Nursey, Mitchell, Tessier-Cloutier, Basile, Jones, Steven J. M., Huntsman, David G., Gilks, C. Blake, Bashashati, Ali

Ovarian cancer is the most lethal cancer of the female reproductive organs. There are $5$ major histological subtypes of epithelial ovarian cancer, each with distinct morphological, genetic, and clinical features. Currently, these histotypes are dete

Externí odkaz: http://arxiv.org/abs/2005.10957

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Harmonized molecular classification; assessment of a single-test ProMisE NGS tool

Autor: Jamieson, Amy ^{a, 1}, McConechy, Melissa K. ^{b, 1}, Lum, Amy ^c, Leung, Samuel ^c, Thompson, Emily F. ^c, Senz, Janine ^c, Talhouk, Aline ^c, Huntsman, David G. ^{b, c}, Bashashati, Ali ^{d, e}, Gilks, C. Blake ^e, McAlpine, Jessica N. ^{a, ⁎}

Publikováno v: In Gynecologic Oncology August 2023 175:45-52

Molecular subtype stratified outcomes according to adjuvant therapy in endometrial cancer

Autor: Jamieson, Amy ^a, Huvila, Jutta ^b, Leung, Samuel ^c, Chiu, Derek ^c, Thompson, Emily F. ^c, Lum, Amy ^c, Kinloch, Mary ^d, Helpman, Limor ^e, Salvador, Shannon ^f, Vicus, Danielle ^g, Kean, Sarah ^h, Samouelian, Vanessa ⁱ, Grondin, Katherine ^j, Irving, Julie ^k, Offman, Saul ^l, Parra-Herran, Carlos ^m, Lau, Susie ^f, Scott, Stephanie ⁿ, Plante, Marie ^o, McConechy, Melissa K. ^p, Huntsman, David G. ^{c, p}, Talhouk, Aline ^c, Kommoss, Stefan ^q, Gilks, C. Blake ^k, McAlpine, Jessica N. ^{a, ⁎}

Publikováno v: In Gynecologic Oncology March 2023 170:282-289