Zobrazeno 1 - 10
of 19 914
pro vyhledávání: '"HUNTINGTIN protein"'
Autor:
Yao JY; The First Clinical College, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province 110122, PR China., Liu T; The Queen's University of Belfast Joint College, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province 110122, PR China., Hu XR; The First Clinical College, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province 110122, PR China., Sheng H; Institute of Metal Research, Chinese Academy of Sciences, No. 72 Wenhua Road, Shenhe Area, Shenyang 110016, PR China., Chen ZH; The Queen's University of Belfast Joint College, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province 110122, PR China., Zhao HY; Teaching Center for Basic Medical Experiment, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province 110122, PR China., Li XJ; Teaching Center for Basic Medical Experiment, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province 110122, PR China. Electronic address: xiaojia9784@126.com., Wang Y; Department of Chemistry, School of Forensic Medicine, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province 110122, PR China; Liaoning Province Key Laboratory of Forensic Bio-evidence Sciences, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province 110122, PR China; China Medical University Center of Forensic Investigation, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province 110122, PR China. Electronic address: sheep514@163.com., Hao L; Department of Chemistry, School of Forensic Medicine, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province 110122, PR China; Liaoning Province Key Laboratory of Forensic Bio-evidence Sciences, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province 110122, PR China; China Medical University Center of Forensic Investigation, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province 110122, PR China. Electronic address: lhao@cmu.edu.cn.
Publikováno v:
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Nov; Vol. 180, pp. 117557. Date of Electronic Publication: 2024 Oct 13.
Autor:
Zhang Z; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland.; Laboratory for Biomolecular Modeling, School of Life Sciences, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland., Gehin C; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland., Abriata LA; Laboratory for Biomolecular Modeling, School of Life Sciences, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland., Dal Peraro M; Laboratory for Biomolecular Modeling, School of Life Sciences, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland., Lashuel H; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland.
Publikováno v:
ACS chemical neuroscience [ACS Chem Neurosci] 2024 Jun 19; Vol. 15 (12), pp. 2408-2419. Date of Electronic Publication: 2024 May 16.
Autor:
Vauleon, Stephanie1 (AUTHOR), Schutz, Katharina1 (AUTHOR), Massonnet, Benoit1 (AUTHOR), Gruben, Nanda2 (AUTHOR), Manchester, Marianne3 (AUTHOR), Buehler, Alessandra1 (AUTHOR), Schick, Eginhard1 (AUTHOR), Boak, Lauren4 (AUTHOR), Hawellek, David J.5 (AUTHOR) david.hawellek@roche.com
Publikováno v:
Scientific Reports. 4/1/2023, Vol. 13 Issue 1, p1-17. 17p.
Autor:
Alteen MG; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada; POINT Biopharma, 22 St Clair Avenue E Suite 1201, Toronto, ON M4T 2S3, Canada., Deme JC; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA., Alvarez CP; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada; SCIEX, 71 Four Valley Dr, Vaughan, ON L4K 4V8, Canada., Loppnau P; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada., Hutchinson A; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada., Seitova A; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada., Chandrasekaran R; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada., Silva Ramos E; Neuroproteomics, Max Delbrück Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125 Berlin, Germany., Secker C; Neuroproteomics, Max Delbrück Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125 Berlin, Germany., Alqazzaz M; Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Wanker EE; Neuroproteomics, Max Delbrück Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125 Berlin, Germany., Lea SM; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA., Arrowsmith CH; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada; Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada. Electronic address: cheryl.arrowsmith@uhnresearch.ca., Harding RJ; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: rachel.harding@utoronto.ca.
Publikováno v:
Structure (London, England : 1993) [Structure] 2023 Sep 07; Vol. 31 (9), pp. 1121-1131.e6. Date of Electronic Publication: 2023 Jun 29.
Autor:
Sun X; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390.; The Ministry of Education Key Laboratory of Reproductive Genetics, Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China., Liu L; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390., Wu C; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390., Li X; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390., Guo J; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390., Zhang J; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390., Guan J; Cui-ying Experimental Center, Lanzhou University Second Hospital, Lanzhou 730030, China., Wang N; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human behavior, University of California, Los Angeles, CA 90095.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095., Gu L; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390., Yang XW; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human behavior, University of California, Los Angeles, CA 90095.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095., Li GM; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390.; Institute for Cancer Research, Chinese Institutes for Medical Research, Beijing 100069, China.; School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Mar 26; Vol. 121 (13), pp. e2313652121. Date of Electronic Publication: 2024 Mar 18.
Autor:
Bonavita R; Department of Molecular Medicine and Medical Biotechnologies, University of Naples 'Federico II', 80131 Naples, Italy., Scerra G; Department of Molecular Medicine and Medical Biotechnologies, University of Naples 'Federico II', 80131 Naples, Italy., Di Martino R; Institute for Endocrinology and Experimental Oncology 'G. Salvatore,' National Research Council, 80131 Naples, Italy.; Institute of Biochemistry and Cell Biology, National Research Council, 80131 Naples, Italy., Nuzzo S; IRCCS SYNLAB SDN, 80143 Naples, Italy., Polishchuk E; Telethon Institute of Genetics and Medicine (TIGEM), 80078 Pozzuoli, Italy., Di Gennaro M; Department of Molecular Medicine and Medical Biotechnologies, University of Naples 'Federico II', 80131 Naples, Italy., Williams SV; Department of Physiology, Development and Neuroscience, University of Cambridge, CB2 3DY Cambridge, UK., Caporaso MG; Department of Molecular Medicine and Medical Biotechnologies, University of Naples 'Federico II', 80131 Naples, Italy., Caiazza C; Department of Molecular Medicine and Medical Biotechnologies, University of Naples 'Federico II', 80131 Naples, Italy., Polishchuk R; Telethon Institute of Genetics and Medicine (TIGEM), 80078 Pozzuoli, Italy., D'Agostino M; Department of Molecular Medicine and Medical Biotechnologies, University of Naples 'Federico II', 80131 Naples, Italy., Fleming A; Department of Physiology, Development and Neuroscience, University of Cambridge, CB2 3DY Cambridge, UK., Renna M; Department of Molecular Medicine and Medical Biotechnologies, University of Naples 'Federico II', 80131 Naples, Italy.; Department of Physiology, Development and Neuroscience, University of Cambridge, CB2 3DY Cambridge, UK.
Publikováno v:
Human molecular genetics [Hum Mol Genet] 2023 Jul 04; Vol. 32 (14), pp. 2269-2291.
Autor:
Fodale, Valentina1 (AUTHOR), Pintauro, Roberta1 (AUTHOR), Daldin, Manuel1 (AUTHOR), Spiezia, Maria Carolina1 (AUTHOR), Macdonald, Douglas2 (AUTHOR) douglas.macdonald@chdifoundation.org, Bresciani, Alberto1 (AUTHOR)
Publikováno v:
Journal of Huntington's Disease. 2022, Vol. 11 Issue 3, p291-305. 15p.
Autor:
Sun, He1 (AUTHOR) hesun1999@163.com, Li, Miao1 (AUTHOR) 19863348219@163.com, Li, Yunling2 (AUTHOR) ll1946842634@163.com, Zheng, Na1 (AUTHOR) 15552371335@163.com, Li, Jiaxin3 (AUTHOR) 13840646328@163.com, Li, Xiang4 (AUTHOR) 13390178665@163.com, Liu, Yingying1 (AUTHOR) liuying568@yeah.net, Ji, Qianyun1 (AUTHOR) jqy17749855497@163.com, Zhou, Liping1 (AUTHOR) zlp13050245797@163.com, Su, Jingwen5 (AUTHOR) yykfire2024@163.com, Huang, Wanxu2 (AUTHOR) huangwx@syphu.edu.cn, Liu, Zhongbo6 (AUTHOR) liuzhongbo@syphu.edu.cn, Liu, Peng1 (AUTHOR) pengliu@syphu.edu.cn, Zou, Libo1 (AUTHOR) pengliu@syphu.edu.cn
Publikováno v:
International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 14, p7709. 16p.
Autor:
Tomczyk, Marta1 (AUTHOR), Glaser, Talita2 (AUTHOR), Ulrich, Henning2 (AUTHOR), Slominska, Ewa M.1 (AUTHOR), Smolenski, Ryszard T.1 (AUTHOR)
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 2022, Vol. 41 Issue 3, p231-238. 8p.
Autor:
Jia-yuan Yao, Ting Liu, Xin-ru Hu, Hui Sheng, Zi-hao Chen, Hai-yang Zhao, Xiao-jia Li, Yang Wang, Liang Hao
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117557- (2024)
Huntington's disease (HD), a monogenic neurodegenerative disorder, stems from a CAG repeat expansion within the mutant huntingtin gene (HTT). This leads to a detrimental gain-of-function of the mutated huntingtin protein (mHTT). As of now, there exis
Externí odkaz:
https://doaj.org/article/f0d531e76919463f858533a7a93cf516