Zobrazeno 1 - 10
of 1 860
pro vyhledávání: '"HUMDISEASE"'
Autor:
Cathy Slack, Jake Jacobson, Janne M. Toivonen, Fiona Kerr, Linda Partridge, Andrea Foley, Ivana Bjedov
Publikováno v:
Cell Metabolism
Cell Metab
Cell Metab
Summary The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evolutionarily diverse organisms including mammals. The central component of this pathway, TOR kinase, is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a631df0736d17bea1fdb4a6b579b15f7
http://europepmc.org/articles/PMC2824086
http://europepmc.org/articles/PMC2824086
Autor:
Rafael Luján, Ainhoa Bilbao, Bénédicte Balland, Briac Halbout, Rolf Sprengel, Carles Sanchis-Segura, Christian Lüscher, Rainer Spanagel, Günther Schütz, Jan Rodriguez Parkitna, David Engblom, Lionel Dahan, Rosanna Parlato, Stephanie Perreau-Lenz, Manuel Mameli
Publikováno v:
Neuron, Vol. 59, No 3 (2008) pp. 497-508
Neuron
Neuron
SummaryCocaine strengthens excitatory synapses onto midbrain dopamine neurons through the synaptic delivery of GluR1-containing AMPA receptors. This cocaine-evoked plasticity depends on NMDA receptor activation, but its behavioral significance in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c508e5294c1eb524bd95b3918f34b0a9
Autor:
Xiaosong Ma, Pablo J. Enriori, C. Ronald Kahn, Chun Xu, Frances M. Ashcroft, Ruth Janoschek, Brigitte Hampel, Sabine D. Jordan, Eva Rother, Jens C. Brüning, A. Christine Könner, Gregory S. Barsh, Leona Plum, Michael A. Cowley
Publikováno v:
Monash University
SummaryInsulin action in the central nervous system regulates energy homeostasis and glucose metabolism. To define the insulin-responsive neurons that mediate these effects, we generated mice with selective inactivation of the insulin receptor (IR) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c016b567d398a14c57e03151665e6b38
https://ora.ox.ac.uk/objects/uuid:e136f6b4-8c92-4ff2-8937-40894dd5d76e
https://ora.ox.ac.uk/objects/uuid:e136f6b4-8c92-4ff2-8937-40894dd5d76e
Autor:
Luisa Capalbo, Gabriel Lopez-Berestein, Robert C. Bast, David D.L. Bowtell, Warren S.-L. Liao, David M. Glover, Nuno L. Barbosa-Morais, Pablo E. Vivas-Mejia, Ahmed Ashour Ahmed, Geoffrey Bartholomeusz, Zhen Lu, Dariush Etemadmoghadam, Xiao Feng Le, Rodrigo Jacamo, Geoffrey Grandjean, Anil K. Sood, Michael Andreeff, Nicholas B. Jennings
SummaryRegulators of mitosis have been successfully targeted to enhance response to taxane chemotherapy. Here, we show that the salt inducible kinase 2 (SIK2) localizes at the centrosome, plays a key role in the initiation of mitosis, and regulates t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e336e470a9c5d6bc0c9fed5f13b9a8a2
https://ora.ox.ac.uk/objects/uuid:dc7cd1a4-f389-4870-b921-4c723d5915f5
https://ora.ox.ac.uk/objects/uuid:dc7cd1a4-f389-4870-b921-4c723d5915f5
Autor:
Yang De Marinis, Stefan Amisten, Patrik Rorsman, Yusuke Moritoh, Tadao Shibasaki, Martin Bengtsson, Susumu Seino, Reshma Ramracheya, Quan Zhang, Orit Braha, Enming Zhang, Fernando Abdulkader, Albert Salehi, Erik Renström, Matthias Braun, Fiona M. Gribble, Frank Reimann, Caroline E. Ward, Lena Eliasson, Abdella M. Habib, Anders Rosengren
Publikováno v:
Cell Metabolism; 11(6), pp 543-553 (2010)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Glucagon secretion is inhibited by glucagon-like peptide-1 (GLP-1) and stimulated by adrenaline. These opposing effects on glucagon secretion are mimicked by low (1-10 nM) and high (10 muM) concentrations of forskolin, respectively. The expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b2f94a42a3a0ea06c89c48e1538c3f
https://doi.org/10.1016/j.cmet.2010.04.007
https://doi.org/10.1016/j.cmet.2010.04.007
Autor:
Brent S. McKenzie, Daniel J. Cua, Barbara Joyce-Shaikh, Nicolas Robinson, Fiona Powrie, Holm H. Uhlig, Sophie Hue, Renata Stepankova, Helena Tlaskalova-Hogenova, Claire Thompson, Sofia Buonocore
The CD40-CD154 pathway is important in the pathogenesis of inflammatory bowel disease. Here we show that injection of an agonistic CD40 mAb to T and B cell-deficient mice was sufficient to induce a pathogenic systemic and intestinal innate inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc264f01664cf4e2a3d07cac374afc91
https://doi.org/10.1016/j.immuni.2006.05.017
https://doi.org/10.1016/j.immuni.2006.05.017
Autor:
Sonya M. Schermann, Manajit Hayer-Hartl, F. Ulrich Hartl, Michael H. Hecht, Heidi Olzscha, Michele Vendruscolo, R. Martin Vabulas, Stefan Pinkert, Andreas C. Woerner, Gian Gaetano Tartaglia
Publikováno v:
Cell; Vol 144
Cell
Cell
SummaryProtein aggregation is linked with neurodegeneration and numerous other diseases by mechanisms that are not well understood. Here, we have analyzed the gain-of-function toxicity of artificial β sheet proteins that were designed to form amyloi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5590885129943d31641581cb7807b2
Autor:
David A. Stoltz, Michael V. Rector, Kathryn Chaloner, Philip H. Karp, Leah R. Reznikov, Jeng-Haur Chen, Alejandro A. Pezzulo, Sarah E. Ernst, Janice L. Launspach, Thomas O. Moninger, Michael J. Welsh, Joseph Zabner
Publikováno v:
Cell. 143(6):911-923
Defective transepithelial electrolyte transport is thought to initiate cystic fibrosis (CF) lung disease. Yet, how loss of CFTR affects electrolyte transport remains uncertain. CFTR -/- pigs spontaneously develop lung disease resembling human CF. At
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed092b24195c045fe139e377d0f24cc5
Autor:
Carsten Janke, Jean-Christophe Deloulme, Annie Andrieux, Max Holzer, Christophe Bosc, Montserrat Bosch Grau, Leticia Peris, Nicole Bec, Nicholas D. Gold, Solange Desagher, Benjamin Lacroix, Christian Larroque, Krzysztof Rogowski, Juliette van Dijk, Marie-Jo Moutin, Anouk Bosson, Maria M. Magiera
Publikováno v:
Cell
Cell, Elsevier, 2010, 143 (4), pp.564-78. 〈10.1016/j.cell.2010.10.014〉
Cell, 2010, 143 (4), pp.564-78. ⟨10.1016/j.cell.2010.10.014⟩
Cell, Elsevier, 2010, 143 (4), pp.564-78. ⟨10.1016/j.cell.2010.10.014⟩
Cell, Elsevier, 2010, 143 (4), pp.564-78. 〈10.1016/j.cell.2010.10.014〉
Cell, 2010, 143 (4), pp.564-78. ⟨10.1016/j.cell.2010.10.014⟩
Cell, Elsevier, 2010, 143 (4), pp.564-78. ⟨10.1016/j.cell.2010.10.014⟩
International audience; Polyglutamylation is a posttranslational modification that generates glutamate side chains on tubulins and other proteins. Although this modification has been shown to be reversible, little is known about the enzymes catalyzin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa912745ac8865d6642a049671ea036
Autor:
Andrew M. Hebbeler, Gilad Doitsh, Marielle Cavrois, Zhiyuan Yang, Kara G. Lassen, Orlando Zepeda, Warner C. Greene, Mario L. Santiago
Publikováno v:
Cell. 143:789-801
SummaryThe mechanism by which CD4 T cells are depleted in HIV-infected hosts remains poorly understood. In ex vivo cultures of human tonsil tissue, CD4 T cells undergo a pronounced cytopathic response following HIV infection. Strikingly, >95% of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c570b4d481a710f726defeb46dc26df3
https://doi.org/10.1016/j.cell.2010.11.001
https://doi.org/10.1016/j.cell.2010.11.001