Zobrazeno 1 - 10
of 11 757
pro vyhledávání: '"HUMAN-MONOCYTES"'
Autor:
Harindra E. Amarasinghe, Ping Zhang, Justin P. Whalley, Alice Allcock, Gabriele Migliorini, Andrew C. Brown, Giuseppe Scozzafava, Julian C. Knight
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-19 (2023)
Abstract Background Monocytes are key mediators of innate immunity to infection, undergoing profound and dynamic changes in epigenetic state and immune function which are broadly protective but may be dysregulated in disease. Here, we aimed to advanc
Externí odkaz:
https://doaj.org/article/5ab61c5126b04d9f9db2e20d3b2d1e7a
Autor:
Ali Youness, Claire Cenac, Berenice Faz-López, Solange Grunenwald, Franck J. Barrat, Julie Chaumeil, José Enrique Mejía, Jean-Charles Guéry
Publikováno v:
Biology of Sex Differences, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Background Human endosomal Toll-like receptors TLR7 and TLR8 recognize self and non-self RNA ligands, and are important mediators of innate immunity and autoimmune pathogenesis. TLR7 and TLR8 are, respectively, encoded by adjacent X-linked g
Externí odkaz:
https://doaj.org/article/12a29fbec5934323b640eaaa56e2984a
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The canonical NOD-like receptor family pyrin domain containing 3 (NLRP3) pathway involves a priming step to induce pro-IL-1β followed by a secondary signal such as K+ efflux to activate inflammasome formation. This then leads to the maturation of IL
Externí odkaz:
https://doaj.org/article/5cd1a8c0fbcc4e3a85acdbbdd2a06345
Autor:
Pedro Pablo Martínez-Rojas, Verónica Monroy-Martínez, Lourdes Teresa Agredano-Moreno, Luis Felipe Jiménez-García, Blanca H. Ruiz-Ordaz
Publikováno v:
Cells, Vol 13, Iss 2, p 144 (2024)
Zika fever is a reemerging arthropod-borne viral disease; however, Zika virus (ZIKV) can be transmitted by other, non-vector means. Severe Zika fever is characterized by neurological disorders, autoimmunity, or congenital Zika syndrome. Monocytes are
Externí odkaz:
https://doaj.org/article/8e07adac1fe048d78560af0c98d55f26
Publikováno v:
Biochemistry and Biophysics Reports, Vol 32, Iss , Pp 101369- (2022)
Programmed cell death 1 (PD-1) is a co-inhibitory checkpoint receptor expressed in various immune cells, especially in activated T cells. Engagement of PD-1 with its ligand leads to the exhausted T cells and impaired antitumor immunity. To date, PD-1
Externí odkaz:
https://doaj.org/article/aa18134eac2846318b041f5e045b3dbb
Autor:
Norbert J. Roberts
Publikováno v:
Viruses, Vol 15, Iss 3, p 759 (2023)
In the pathogenesis of influenza virus infection, lymphocyte apoptosis as a part of the infection and/or the immune response to the virus can be somewhat puzzling. The percentage of human T lymphocytes within the peripheral blood mononuclear cell pop
Externí odkaz:
https://doaj.org/article/a90b166b25c94552b4f675f5b061f36d
Autor:
Pierre-Louis Krauss, Moritz Pfeiffenberger, Alexandra Damerau, Thomas Buttgereit, Yuling Chen, Timo Gaber, Frank Buttgereit
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
At sites of inflammation, monocytes carry out specific immune functions while facing challenging metabolic restrictions. Here, we investigated the potential of human monocytes to adapt to conditions of gradually inhibited oxidative phosphorylation (O
Externí odkaz:
https://doaj.org/article/0de51965945d4126b3318f16b711568e
Autor:
Sophie A. Aschenbroich, Eric R. Lafontaine, Maria Cecilia Lopez, Henry V. Baker, Robert J. Hogan
Publikováno v:
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-16 (2019)
Abstract Background Burkholderia mallei (Bm) is a facultative intracellular bacterial pathogen causing highly-fatal glanders in solipeds and humans. The ability of Bm to thrive intracellularly is thought to be related to exploitation of host immune r
Externí odkaz:
https://doaj.org/article/5250370218594b9181bf0aca15e55b97
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Akademický článek
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