Zobrazeno 1 - 10
of 1 149
pro vyhledávání: '"HUMAN PANCREATIC-ISLETS"'
Autor:
Sevim Kahraman, Kimitaka Shibue, Dario F De Jesus, Hyunki Kim, Jiang Hu, Debasish Manna, Bridget Wagner, Amit Choudhary, Rohit N Kulkarni
Publikováno v:
eLife, Vol 12 (2023)
Pancreatic α-cells secrete glucagon, an insulin counter-regulatory peptide hormone critical for the maintenance of glucose homeostasis. Investigation of the function of human α-cells remains a challenge due to the lack of cost-effective purificatio
Externí odkaz:
https://doaj.org/article/b75a7103ed324acca5108365e616c62c
Autor:
Amanda Marchini, Maria Gessica Ciulla, Barbara Antonioli, Alessandro Agnoli, Umberto Bovio, Virginia Visnoviz, Federico Bertuzzi, Fabrizio Gelain
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Human pancreatic islets transplantation is an experimental therapeutic treatment for Type I Diabetes. Limited islets lifespan in culture remains the main drawback, due to the absence of native extracellular matrix as mechanical support after their en
Externí odkaz:
https://doaj.org/article/7f249e73891845fc8d385242144d2a7b
Autor:
Hiroyuki Kato, Tatsuaki Miwa, Janine Quijano, Leonard Medrano, Jose Ortiz, Akiko Desantis, Keiko Omori, Aya Wada, Kentaro Tatsukoshi, Fouad Kandeel, Yoko Mullen, Hsun Teresa Ku, Hirotake Komatsu
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
BackgroundTransplantation of the human pancreatic islets is a promising approach for specific types of diabetes to improve glycemic control. Although effective, there are several issues that limit the clinical expansion of this treatment, including d
Externí odkaz:
https://doaj.org/article/464c9420acd848cba8fbb35c40f514de
Autor:
Leandro D. Teixeira, Natalie A. Harrison, Danilo R. da Silva, Clayton E. Mathews, Claudio F. Gonzalez, Graciela L. Lorca
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
L. johnsonii N6.2 releases nano-sized vesicles (NVs) with distinct protein and lipid contents. We hypothesized that these NVs play a central role in the delivery of bioactive molecules that may act as mechanistic effectors in immune modulation. In th
Externí odkaz:
https://doaj.org/article/9c442b6f66d044c796940bf62d993d6a
Akademický článek
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Autor:
Lorella Marselli, Anthony Piron, Mara Suleiman, Maikel L. Colli, Xiaoyan Yi, Amna Khamis, Gaelle R. Carrat, Guy A. Rutter, Marco Bugliani, Laura Giusti, Maurizio Ronci, Mark Ibberson, Jean-Valery Turatsinze, Ugo Boggi, Paolo De Simone, Vincenzo De Tata, Miguel Lopes, Daniela Nasteska, Carmela De Luca, Marta Tesi, Emanuele Bosi, Pratibha Singh, Daniela Campani, Anke M. Schulte, Michele Solimena, Peter Hecht, Brian Rady, Ivona Bakaj, Alessandro Pocai, Lisa Norquay, Bernard Thorens, Mickaël Canouil, Philippe Froguel, Decio L. Eizirik, Miriam Cnop, Piero Marchetti
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108466- (2020)
Summary: Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we assess whether human β cell dysfunction induced by metabolic stress is reversible, evaluate the molecular pathways underlying persistent or transient
Externí odkaz:
https://doaj.org/article/28763563ad6f4edd9dcabcb486fa39a2
Autor:
Daniela Fignani, Giada Licata, Noemi Brusco, Laura Nigi, Giuseppina E. Grieco, Lorella Marselli, Lut Overbergh, Conny Gysemans, Maikel L. Colli, Piero Marchetti, Chantal Mathieu, Decio L. Eizirik, Guido Sebastiani, Francesco Dotta
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Increasing evidence demonstrated that the expression of Angiotensin I-Converting Enzyme type 2 (ACE2) is a necessary step for SARS-CoV-2 infection permissiveness. In light of the recent data highlighting an association between COVID-19 and diabetes,
Externí odkaz:
https://doaj.org/article/05d99993f96f49f999863eb96b71f66c
Akademický článek
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Autor:
Nathalie Groen, Floris Leenders, Ahmed Mahfouz, Amadeo Munoz-Garcia, Mauro J. Muraro, Natascha de Graaf, Ton. J. Rabelink, Rob Hoeben, Alexander van Oudenaarden, Arnaud Zaldumbide, Marcel J. T. Reinders, Eelco J. P. de Koning, Françoise Carlotti
Publikováno v:
Cells, Vol 10, Iss 12, p 3585 (2021)
The maintenance of pancreatic islet architecture is crucial for proper β-cell function. We previously reported that disruption of human islet integrity could result in altered β-cell identity. Here we combine β-cell lineage tracing and single-cell
Externí odkaz:
https://doaj.org/article/f3c90ac516944d4881188fb096b01cc1
Akademický článek
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