Zobrazeno 1 - 10
of 192
pro vyhledávání: '"HULL, M.A."'
Autor:
Sun, G., Fuller, H., Fenton, H., Race, Amanda D., Downing, A., Williams, E.A., Rees, C.J., Brown, L.C., Loadman, Paul, Hull, M.A.
Yes
Urinary prostaglandin (PG) E metabolite (PGE-M) and 11-dehydro (d)-thromboxane (TX) B2 are biomarkers of cyclooxygenase-dependent prostanoid synthesis. We investigated (1) the effect of aspirin 300 mg daily and eicosapentaenoic acid (EPA) 20
Urinary prostaglandin (PG) E metabolite (PGE-M) and 11-dehydro (d)-thromboxane (TX) B2 are biomarkers of cyclooxygenase-dependent prostanoid synthesis. We investigated (1) the effect of aspirin 300 mg daily and eicosapentaenoic acid (EPA) 20
Externí odkaz:
http://hdl.handle.net/10454/19689
Autor:
Sun, G., Davies, J.R., Mell, T., Harland, M., Saleh, R.M.H., Race, Amanda D., Loadman, Paul, Williams, E.A., Minihane, A.M., Hull, M.A.
Yes
Introduction: We examined the relationship between Apolipoprotein E (APOE) genotype and n-3 highly unsaturated fatty acid (HUFA) levels in participants of the seAFOod trial, who were undergoing colonoscopy surveillance after removal of color
Introduction: We examined the relationship between Apolipoprotein E (APOE) genotype and n-3 highly unsaturated fatty acid (HUFA) levels in participants of the seAFOod trial, who were undergoing colonoscopy surveillance after removal of color
Externí odkaz:
http://hdl.handle.net/10454/19979
Autor:
Hull, M.A., Ow, P.L., Ruddock, S., Brend, T., Smith, A.F., Marshall, H., Song, M., Chan, A.T., Garrett, W.S., Yilmaz, O., Drew, D.A., Collinson, F., Cockbain, A.J., Jones, R., Loadman, Paul, Hall, P.S., Moriarty, C., Cairns, D.A., Toogood, G.J.
Yes
There remains an unmet need for safe and cost-effective adjunctive treatment of advanced colorectal cancer (CRC). The omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) is safe, well-tolerated and has anti-inflammatory as well as
There remains an unmet need for safe and cost-effective adjunctive treatment of advanced colorectal cancer (CRC). The omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) is safe, well-tolerated and has anti-inflammatory as well as
Externí odkaz:
http://hdl.handle.net/10454/19719
Autor:
Davies, J.R., Mell, T., Fuller, H., Harland, M., Saleh, R.N.M., Race, Amanda D., Rees, C.J., Brown, L.C., Loadman, Paul, Downing, A., Minihane, A.M., Williams, E.A., Hull, M.A.
Yes
Aspirin and eicosapentaenoic acid (EPA) reduce colorectal adenomatous polyp risk and affect synthesis of oxylipins including prostaglandin E2. We investigated whether 35 single nucleotide polymorphisms (SNPs) in oxylipin metabolism genes suc
Aspirin and eicosapentaenoic acid (EPA) reduce colorectal adenomatous polyp risk and affect synthesis of oxylipins including prostaglandin E2. We investigated whether 35 single nucleotide polymorphisms (SNPs) in oxylipin metabolism genes suc
Externí odkaz:
http://hdl.handle.net/10454/19688
Autor:
Downing, A., Fenton, H., Nickerson, C., Loadman, Paul, Williams, E.A., Rees, C.J., Brown, L.C., Morris, E.J.A., Hull, M.A.
Yes
The seAFOod polyp prevention trial was a randomised, placebo-controlled, 2 × 2 factorial trial of aspirin 300 mg and eicosapentaenoic acid (EPA) 2000 mg daily in individuals who had a screening colonoscopy in the English Bowel Cancer Screen
The seAFOod polyp prevention trial was a randomised, placebo-controlled, 2 × 2 factorial trial of aspirin 300 mg and eicosapentaenoic acid (EPA) 2000 mg daily in individuals who had a screening colonoscopy in the English Bowel Cancer Screen
Externí odkaz:
http://hdl.handle.net/10454/19635
Autor:
Fuller, H., Race, Amanda D., Fenton, H., Burke, L., Downing, A., Williams, E.A., Rees, C.J., Brown, L.C., Loadman, Paul, Hull, M.A.
Yes
Aspirin and eicosapentaenoic acid (EPA) have colorectal polyp prevention activity, alone and in combination. This study measured levels of plasma and rectal mucosal oxylipins in participants of the seAFOod 2 × 2 factorial, randomised, place
Aspirin and eicosapentaenoic acid (EPA) have colorectal polyp prevention activity, alone and in combination. This study measured levels of plasma and rectal mucosal oxylipins in participants of the seAFOod 2 × 2 factorial, randomised, place
Externí odkaz:
http://hdl.handle.net/10454/19605
Autor:
Nana, G., Mitra, S., Watson, H., Young, C., Wood, H.M., Perry, S.L., Race, Amanda D., Quirke, P., Toogood, G.J., Loadman, Paul, Hull, M.A.
Yes
Background: Oral administration of purified omega-3 (ω-3) PUFAs is associated with changes to the fecal microbiome. However, it is not known whether this effect is associated with increased PUFA concentrations in the gut. Objectives: We inv
Background: Oral administration of purified omega-3 (ω-3) PUFAs is associated with changes to the fecal microbiome. However, it is not known whether this effect is associated with increased PUFA concentrations in the gut. Objectives: We inv
Externí odkaz:
http://hdl.handle.net/10454/18557
Autor:
Hull, M.A., Sprange, K., Hepburn, T., Tan, W., Shafayat, A., Rees, C.J., Clifford, G., Logan, R.F., Loadman, Paul, Williams, E.A., Whitham, D., Montgomery, A.A.
Yes
Background: The omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) and aspirin both have proof of concept for colorectal cancer chemoprevention, aligned with an excellent safety profile. Therefore, we aimed to test the efficacy o
Background: The omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) and aspirin both have proof of concept for colorectal cancer chemoprevention, aligned with an excellent safety profile. Therefore, we aimed to test the efficacy o
Externí odkaz:
http://hdl.handle.net/10454/16687
Autor:
Watson, H., Mitra, S., Croden, F.C., Taylor, M., Wood, H.M., Perry, S.L., Spencer, Jade A., Quirke, P., Toogood, G.J., Lawton, C.L., Dye, L., Loadman, Paul, Hull, M.A.
Yes
Objective Omega-3 polyunsaturated fatty acids (PUFAs) have anticolorectal cancer (CRC) activity. The intestinal microbiota has been implicated in colorectal carcinogenesis. Dietary omega-3 PUFAs alter the mouse intestinal microbiome compatib
Objective Omega-3 polyunsaturated fatty acids (PUFAs) have anticolorectal cancer (CRC) activity. The intestinal microbiota has been implicated in colorectal carcinogenesis. Dietary omega-3 PUFAs alter the mouse intestinal microbiome compatib
Externí odkaz:
http://hdl.handle.net/10454/13400
Autor:
Watson, H., Cockbain, A.J., Spencer, Jade A., Race, Amanda D., Volpato, Milène, Loadman, Paul, Toogood, G.J., Hull, M.A.
Yes
We investigated red blood cell (RBC) PUFA profiles, and the predictive value of RBC EPA content for tumour EPA exposure and clinical outcomes, in the EMT study, a randomised trial of EPA in patients awaiting colorectal cancer (CRC) liver met
We investigated red blood cell (RBC) PUFA profiles, and the predictive value of RBC EPA content for tumour EPA exposure and clinical outcomes, in the EMT study, a randomised trial of EPA in patients awaiting colorectal cancer (CRC) liver met
Externí odkaz:
http://hdl.handle.net/10454/10200