The FBXO32/ATR/ATM axis acts as a molecular switch to control the sensitivity of osteosarcoma cells to irradiation through its regulation of EXO1 expression

Autor: Lu Yao, Huang Panpan, Li Yanli, Liu Wenyu, Li Jing, Zhao Rui, Feng Haihua, Shi Ce, Cao Gaolu

Publikováno v: Acta Biochimica et Biophysica Sinica, Vol 55, Pp 842-852 (2023)

Osteosarcoma (OS) is the most common primary bone cancer in children and adolescents. In clinical treatments, the insensitivity of OS to conventional radiotherapy regimens significantly contributes to poor patient prognosis and survival. EXO1 is resp

Externí odkaz: https://doaj.org/article/fce5f0ffc8684743adb182145e42368d

Fire-Flyer AI-HPC: A Cost-Effective Software-Hardware Co-Design for Deep Learning

Autor: An, Wei, Bi, Xiao, Chen, Guanting, Chen, Shanhuang, Deng, Chengqi, Ding, Honghui, Dong, Kai, Du, Qiushi, Gao, Wenjun, Guan, Kang, Guo, Jianzhong, Guo, Yongqiang, Fu, Zhe, He, Ying, Huang, Panpan, Li, Jiashi, Liang, Wenfeng, Liu, Xiaodong, Liu, Xin, Liu, Yiyuan, Liu, Yuxuan, Lu, Shanghao, Lu, Xuan, Nie, Xiaotao, Pei, Tian, Qiu, Junjie, Qu, Hui, Ren, Zehui, Sha, Zhangli, Su, Xuecheng, Sun, Xiaowen, Tan, Yixuan, Tang, Minghui, Wang, Shiyu, Wang, Yaohui, Wang, Yongji, Xie, Ziwei, Xiong, Yiliang, Xu, Yanhong, Ye, Shengfeng, Yu, Shuiping, Zha, Yukun, Zhang, Liyue, Zhang, Haowei, Zhang, Mingchuan, Zhang, Wentao, Zhang, Yichao, Zhao, Chenggang, Zhao, Yao, Zhou, Shangyan, Zhou, Shunfeng, Zou, Yuheng

The rapid progress in Deep Learning (DL) and Large Language Models (LLMs) has exponentially increased demands of computational power and bandwidth. This, combined with the high costs of faster computing chips and interconnects, has significantly infl

Externí odkaz: http://arxiv.org/abs/2408.14158

DeepSeek-V2: A Strong, Economical, and Efficient Mixture-of-Experts Language Model

Autor: DeepSeek-AI, Liu, Aixin, Feng, Bei, Wang, Bin, Wang, Bingxuan, Liu, Bo, Zhao, Chenggang, Dengr, Chengqi, Ruan, Chong, Dai, Damai, Guo, Daya, Yang, Dejian, Chen, Deli, Ji, Dongjie, Li, Erhang, Lin, Fangyun, Luo, Fuli, Hao, Guangbo, Chen, Guanting, Li, Guowei, Zhang, H., Xu, Hanwei, Yang, Hao, Zhang, Haowei, Ding, Honghui, Xin, Huajian, Gao, Huazuo, Li, Hui, Qu, Hui, Cai, J. L., Liang, Jian, Guo, Jianzhong, Ni, Jiaqi, Li, Jiashi, Chen, Jin, Yuan, Jingyang, Qiu, Junjie, Song, Junxiao, Dong, Kai, Gao, Kaige, Guan, Kang, Wang, Lean, Zhang, Lecong, Xu, Lei, Xia, Leyi, Zhao, Liang, Zhang, Liyue, Li, Meng, Wang, Miaojun, Zhang, Mingchuan, Zhang, Minghua, Tang, Minghui, Li, Mingming, Tian, Ning, Huang, Panpan, Wang, Peiyi, Zhang, Peng, Zhu, Qihao, Chen, Qinyu, Du, Qiushi, Chen, R. J., Jin, R. L., Ge, Ruiqi, Pan, Ruizhe, Xu, Runxin, Chen, Ruyi, Li, S. S., Lu, Shanghao, Zhou, Shangyan, Chen, Shanhuang, Wu, Shaoqing, Ye, Shengfeng, Ma, Shirong, Wang, Shiyu, Zhou, Shuang, Yu, Shuiping, Zhou, Shunfeng, Zheng, Size, Wang, T., Pei, Tian, Yuan, Tian, Sun, Tianyu, Xiao, W. L., Zeng, Wangding, An, Wei, Liu, Wen, Liang, Wenfeng, Gao, Wenjun, Zhang, Wentao, Li, X. Q., Jin, Xiangyue, Wang, Xianzu, Bi, Xiao, Liu, Xiaodong, Wang, Xiaohan, Shen, Xiaojin, Chen, Xiaokang, Chen, Xiaosha, Nie, Xiaotao, Sun, Xiaowen, Wang, Xiaoxiang, Liu, Xin, Xie, Xin, Yu, Xingkai, Song, Xinnan, Zhou, Xinyi, Yang, Xinyu, Lu, Xuan, Su, Xuecheng, Wu, Y., Li, Y. K., Wei, Y. X., Zhu, Y. X., Xu, Yanhong, Huang, Yanping, Li, Yao, Zhao, Yao, Sun, Yaofeng, Li, Yaohui, Wang, Yaohui, Zheng, Yi, Zhang, Yichao, Xiong, Yiliang, Zhao, Yilong, He, Ying, Tang, Ying, Piao, Yishi, Dong, Yixin, Tan, Yixuan, Liu, Yiyuan, Wang, Yongji, Guo, Yongqiang, Zhu, Yuchen, Wang, Yuduan, Zou, Yuheng, Zha, Yukun, Ma, Yunxian, Yan, Yuting, You, Yuxiang, Liu, Yuxuan, Ren, Z. Z., Ren, Zehui, Sha, Zhangli, Fu, Zhe, Huang, Zhen, Zhang, Zhen, Xie, Zhenda, Hao, Zhewen, Shao, Zhihong, Wen, Zhiniu, Xu, Zhipeng, Zhang, Zhongyu, Li, Zhuoshu, Wang, Zihan, Gu, Zihui, Li, Zilin, Xie, Ziwei

We present DeepSeek-V2, a strong Mixture-of-Experts (MoE) language model characterized by economical training and efficient inference. It comprises 236B total parameters, of which 21B are activated for each token, and supports a context length of 128

Externí odkaz: http://arxiv.org/abs/2405.04434

DeepSeek LLM: Scaling Open-Source Language Models with Longtermism

Autor: DeepSeek-AI, Bi, Xiao, Chen, Deli, Chen, Guanting, Chen, Shanhuang, Dai, Damai, Deng, Chengqi, Ding, Honghui, Dong, Kai, Du, Qiushi, Fu, Zhe, Gao, Huazuo, Gao, Kaige, Gao, Wenjun, Ge, Ruiqi, Guan, Kang, Guo, Daya, Guo, Jianzhong, Hao, Guangbo, Hao, Zhewen, He, Ying, Hu, Wenjie, Huang, Panpan, Li, Erhang, Li, Guowei, Li, Jiashi, Li, Yao, Li, Y. K., Liang, Wenfeng, Lin, Fangyun, Liu, A. X., Liu, Bo, Liu, Wen, Liu, Xiaodong, Liu, Xin, Liu, Yiyuan, Lu, Haoyu, Lu, Shanghao, Luo, Fuli, Ma, Shirong, Nie, Xiaotao, Pei, Tian, Piao, Yishi, Qiu, Junjie, Qu, Hui, Ren, Tongzheng, Ren, Zehui, Ruan, Chong, Sha, Zhangli, Shao, Zhihong, Song, Junxiao, Su, Xuecheng, Sun, Jingxiang, Sun, Yaofeng, Tang, Minghui, Wang, Bingxuan, Wang, Peiyi, Wang, Shiyu, Wang, Yaohui, Wang, Yongji, Wu, Tong, Wu, Y., Xie, Xin, Xie, Zhenda, Xie, Ziwei, Xiong, Yiliang, Xu, Hanwei, Xu, R. X., Xu, Yanhong, Yang, Dejian, You, Yuxiang, Yu, Shuiping, Yu, Xingkai, Zhang, B., Zhang, Haowei, Zhang, Lecong, Zhang, Liyue, Zhang, Mingchuan, Zhang, Minghua, Zhang, Wentao, Zhang, Yichao, Zhao, Chenggang, Zhao, Yao, Zhou, Shangyan, Zhou, Shunfeng, Zhu, Qihao, Zou, Yuheng

The rapid development of open-source large language models (LLMs) has been truly remarkable. However, the scaling law described in previous literature presents varying conclusions, which casts a dark cloud over scaling LLMs. We delve into the study o

Externí odkaz: http://arxiv.org/abs/2401.02954

Influence of arc discharge on the temperature and wear behaviors of the contact strip in pantograph-rigid catenary systems under AC conditions

Autor: Hu, Yan, Huang, Panpan, Cheng, Chun, Zhang, Miaomiao, Ma, Ran

Publikováno v: In Wear 1 June 2024 546-547