Zobrazeno 1 - 10
of 36
pro vyhledávání: '"HU, hydroxyurea"'
Autor:
Andrew Dickson, Benjamin R. Stromberg, Christine Insinna, Matthew K. Summers, Yosup Rhee, Adrian E. Torres, Debjani Pal, Christopher J. Westlake, Mayank Singh, Amy C. Burrows
Publikováno v:
The Journal of Biological Chemistry
The deubiquitinating enzyme USP37 is known to contribute to timely onset of S phase and progression of mitosis. However, it is not clear if USP37 is required beyond S-phase entry despite expression and activity of USP37 peaking within S phase. We hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eedf7a343128548aa738f8cb79c88d9
http://europepmc.org/articles/PMC8487067
http://europepmc.org/articles/PMC8487067
Autor:
Terry B. Ruskoski, Amie K. Boal
Publikováno v:
The Journal of Biological Chemistry
In most organisms, transition metal ions are necessary cofactors of ribonucleotide reductase (RNR), the enzyme responsible for biosynthesis of the 2′-deoxynucleotide building blocks of DNA. The metal ion generates an oxidant for an active site cyst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09cecf12ddc55c7368f1020d6a618d2
http://europepmc.org/articles/PMC8463856
http://europepmc.org/articles/PMC8463856
Autor:
Edwin Antony, Urvashi Mahajan, Susana Gonzalo, Simona Graziano, Barbara Teodoro-Castro, Alessandro Vindigni, Sahiti Kuppa, Elena Shashkova, Jessica Jackson, Núria Coll-Bonfill
Publikováno v:
The Journal of Biological Chemistry
Lamin A/C provides a nuclear scaffold for compartmentalization of genome function that is important for genome integrity. Lamin A/C dysfunction is associated with cancer, aging, and degenerative diseases. The mechanisms whereby lamin A/C regulates ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41a81d1c7d4b7e8ad53fa68be97c006
https://pubmed.ncbi.nlm.nih.gov/34648766
https://pubmed.ncbi.nlm.nih.gov/34648766
Publikováno v:
The Journal of Biological Chemistry
Sister chromatid cohesion (SCC), the pairing of sister chromatids after DNA replication until mitosis, is established by loading of the cohesin complex on newly replicated chromatids. Cohesin must then be maintained until mitosis to prevent segregati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcaf01b5bb0a458b635ae4e6c95ef348
http://europepmc.org/articles/PMC8390553
http://europepmc.org/articles/PMC8390553
Autor:
Sophie L. Cooke, Carolin A. Müller, Francisco Meirelles Bastos de Oliveira, Conrad A. Nieduszynski, Bárbara Luísa Soares, Robertus A.M. de Bruin
Publikováno v:
The Journal of Biological Chemistry
Saccharomyces cerevisiae exhibits gene expression homeostasis, which is defined as the buffering of transcription levels against changes in DNA copy number during the S phase of the cell cycle. It has been suggested that S. cerevisiae employs an acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3bb43f54bb71c409f6a061995fd0d90
https://ueaeprints.uea.ac.uk/id/eprint/87851/
https://ueaeprints.uea.ac.uk/id/eprint/87851/
Publikováno v:
The Journal of Biological Chemistry
Proliferating cells coordinate histone and DNA synthesis to maintain correct stoichiometry for chromatin assembly. Histone mRNA levels must be repressed when DNA replication is inhibited to prevent toxicity and genome instability due to free non-chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::939e63ffbbca1f34ff16d8f9f04945c3
https://doi.org/10.1016/j.jbc.2021.101246
https://doi.org/10.1016/j.jbc.2021.101246
Autor:
Adam S. Mastrocola, Weiyan Jia, Peter Tonzi, William M. Guns, Lu Liu, Robert J. Millikin, Randal S. Tibbetts, Sang Hwa Kim, Tony T. Huang, Mark Scalf, Lloyd M. Smith
Publikováno v:
The Journal of Biological Chemistry
Fused in sarcoma (FUS) encodes an RNA-binding protein with diverse roles in transcriptional activation and RNA splicing. While oncogenic fusions of FUS and transcription factor DNA-binding domains are associated with soft tissue sarcomas, dominant mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a9a44d7275f5becac62657ed50f32a
https://doi.org/10.1016/j.jbc.2021.101049
https://doi.org/10.1016/j.jbc.2021.101049
Publikováno v:
The Journal of Biological Chemistry
Eukaryotic proliferating cell nuclear antigen (PCNA) plays an essential role in orchestrating the assembly of the replisome complex, stimulating processive DNA synthesis, and recruiting other regulatory proteins during the DNA damage response. PCNA a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be5851c8ad284093b4072c9bc16057f
https://doi.org/10.1016/j.jbc.2021.100911
https://doi.org/10.1016/j.jbc.2021.100911
Autor:
Alexander Holbrook, Halle Mallard, Meghan Biegert, Natasha Kreiling, Grace Su, Manohar Kodavati, Megan Perry, Gargi Ghosal, Sai Sundeep Kollala
Publikováno v:
The Journal of Biological Chemistry
DNA–protein cross-links (DPCs) are toxic DNA lesions that interfere with DNA metabolic processes such as replication, transcription, and recombination. USP11 deubiquitinase participates in DNA repair, but the role of USP11 in DPC repair is not know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc686d2fa4436240e8db8b60546f0cc
https://doi.org/10.1016/j.jbc.2021.100396
https://doi.org/10.1016/j.jbc.2021.100396
Autor:
David Cortez, Vaughn Thada
Publikováno v:
The Journal of Biological Chemistry
The checkpoint kinase ATR regulates DNA repair, cell cycle progression, and other DNA damage and replication stress responses. ATR signaling is stimulated by an ATR activating protein, and in metazoan cells, there are at least two ATR activators: TOP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0e3da3413dda611f96e575cdcd27c3
https://doi.org/10.1016/j.jbc.2021.100455
https://doi.org/10.1016/j.jbc.2021.100455