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Akademický článek

Brassicasterol with Dual Anti-Infective Properties against HSV-1 and Mycobacterium tuberculosis, and Cardiovascular Protective Effect: Nonclinical In Vitro and In Silico Assessments

Autor: Sherif T. S. Hassan

Publikováno v: Biomedicines, Vol 8, Iss 5, p 132 (2020)

While few studies have revealed the biological properties of brassicasterol, a phytosterol, against some biological and molecular targets, it is believed that there are still many activities yet to be studied. In this work, brassicasterol exerts a th

Externí odkaz: https://doaj.org/article/e5243e048ceb4190a7ef32e03f2504b7

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Akademický článek

C-5 Hydroxyethyl and Hydroxypropyl Acyclonucleosides as Substrates for Thymidine Kinase of Herpes Simplex Virus Type 1 (HSV-1 TK): Syntheses and Biological Evaluation

Autor: Silvana Raić-Malić, Simon M. Ametamey, Leonardo Scapozza, Davorka Završnik, Ursina Müller, Amar Osmanović, Ivana Novaković, Svjetlana Krištafor, Andrijana Meščić

Publikováno v: Molecules, Vol 18, Iss 5, Pp 5104-5124 (2013)

The efficient syntheses of 5-(2-hydroxyethyl)- and 5-(3-hydroxypropyl)-substituted pyrimidine derivatives bearing 2,3-dihydroxypropyl, acyclovir-, ganciclovir- and penciclovir-like side chains are reported. A synthetic approach that included the alky

Externí odkaz: https://doaj.org/article/7e6d1abd87ac407bb52c113da0322b20

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Akademický článek

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C-5 Hydroxyethyl and Hydroxypropyl Acyclonucleosides as Substrates for Thymidine Kinase of Herpes Simplex Virus Type 1 (HSV-1 TK): Syntheses and Biological Evaluation

Autor: Mešcic Adrijana, Krištafor Svjetlana, Novakovic I, Osmanovic Amar, Müller Ursina, Završnik Davorka, Ametamey Simon Mensah, Scapozza Leonardo, Raic-Malic Silvana

Publikováno v: Molecules, 18 (5)
Molecules
Molecules, Vol 18, Iss 5, Pp 5104-5124 (2013)
Volume 18
Issue 5
Pages 5104-5124

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b4a97a7c03dd8aeb58929599ca8d8bb9
https://www.bib.irb.hr/628317

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Bone metastasis imaging with SPECT/CT/MRI: a preclinical toolbox for therapy studies

Autor: Steffie M. B. Peters, Holger Grüll, Pedro Gomes Sanches, Clemens W.G.M. Löwik, Ivo Que, Eric L. Kaijzel, Raffaella Rossin

Publikováno v: Bone, 75, 62-71. Elsevier
BONE, 75, 62-71

Bone is one of the most common metastatic target sites in breast cancer, with more than 200 thousand new cases of invasive cancer diagnosed in the US alone in 2011. We set out to establish a multimodality imaging platform for bone metastases in small

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5874cedf5d3f2dba8538cc7cdceae3fa
https://pubmed.ncbi.nlm.nih.gov/25680341

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Sinteza i biološka ispitivanja C-5 supstituiranih N-dihidroksiizobutilnih derivata pirimidina

Autor: Meščić, Andrijana, Glavač, Danijel, Raić-Malić, Silvana

Strukturni analozi prirodnih nukleozida u kojima je purinski, pirimidinski ili šećerni prsten zamijenjen strukturno srodnom heterocikličkom bazom ili acikličkim lancem imaju izraženu biološku aktivnost [1]. Istraživanje je usmjereno na sintezu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::1589b5327f4b71849ce3820e8f8b787f
https://www.bib.irb.hr/630759

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Sinteza i strukturna karakterizacija disupstituiranih pirimidina s potencijalnom primjenom u pozitron-emisijskoj tomografiji (PET)

Autor: Brkljač, Jasna

Cilj ovog rada bio je sintetizirati derivate uracile s pobočnim lancem poput aciklovira u položaju N-1 kao potencijalne supstrate enzima timidin-kinaze virusa herpes simpleks tipa 1 (HSV-1 TK). Ciljani N1-[(2-hidroksietokis)metil]-5-(2-hidroksietil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::78888c9b8957e20cadfffc4f2b430b85
https://www.bib.irb.hr/495167

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Sinteza i biološka ispitivanja N-alkiliranih derivata pirimidina

Autor: Pišonić, Damir

U ovom je radu opisana sinteza 5-(2-hidroksietil)uracilnih derivata (3-8) kao i derivata timina s izobutilnim (11-15) i izobutenilnim (16) pobočnim lancem u položaju C-6 pirimidina. Ciljani spoj 16 je pirimidinski aciklički analog nukleozida s pot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::9328680971a3c9f21d94ce757fcba02e
https://www.bib.irb.hr/476067

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C-6 aciklički pirimidinski derivati kao supstrati enzima timidin kinaze (HSV-1 TK)

Autor: Novaković, Ivana

Pojedini predstavnici C-6 supstituiranih derivata pirimidina, primjerice 6-hidroksipropiltimin, 6-(3-hidroksi-2-hidroksimetilpropil)timin i 6-(2, 3-dihidroksipropil)timin su dobri supstrati enzima timidin-kinaze herpes simpleks virusa tipa 1 (HSV-1 T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::25dd4b137d87ad4fae175acb0b8fb63e
https://www.bib.irb.hr/495165

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Sinteza i citostatska ispitivanja nukleozidnih mimetika

Autor: Kolar, Iva

U ovom radu opisana je sinteza derivata pirimidina s izobutilnim (5-11) i izobutenilnim (14) lancem u položaju C-6 pirimidina. Ključni C-6 alkilirani derivat pirimidina 5 pripremljen je reakcijom organolitijevog intermedijara 5, 6-dimetil-2, 4-dime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::42bb71569f24aec37f1da562880ad4dd
https://www.bib.irb.hr/485034

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