Zobrazeno 1 - 10
of 27
pro vyhledávání: '"HSPG, heparan sulfate proteoglycan"'
Publikováno v:
Neoplasia (New York, N.Y.)
Early lung carcinoma development may be modulated by innate host cellular mechanisms that promote tumor growth and invasion. We recently identified how a loss-of-function mutation in the glycan sulfating enzyme N-deacetylase/N-sulfotransferase-1 (Nds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c1a8c4e83557920ae120f81f6685b95
http://europepmc.org/articles/PMC8560828
http://europepmc.org/articles/PMC8560828
Akademický článek
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Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 2, Pp 86-97 (2020)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.), vol 22, iss 2
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.), vol 22, iss 2
While recent research points to the importance of glycans in cancer immunity, knowledge on functional mechanisms is lacking. In lung carcinoma among other tumors, anti-tumor immunity is suppressed; and while some recent therapies boost T-cell mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7e0acb8a762ad1ad8ad75a631c6062
http://www.sciencedirect.com/science/article/pii/S1476558619303045
http://www.sciencedirect.com/science/article/pii/S1476558619303045
Publikováno v:
Biochemistry and Biophysics Reports, Vol 29, Iss, Pp 101195-(2022)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
Auto/paracrine factors secreted from cells affect differentiation of human pluripotent stem cells (hPSCs). However, the molecular mechanisms underlying the role of secreted factors are not well known. We previously showed that pattern formation in hP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a969c81eeb80b5d9ec90aadc4fd880
http://www.sciencedirect.com/science/article/pii/S2405580821002892
http://www.sciencedirect.com/science/article/pii/S2405580821002892
Autor:
Vladlena Pfeifer, Heiko Weber, Yuanyuan Wang, Martin Schlesinger, Christian Gorzelanny, Gerd Bendas
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5452
Heparan sulfate proteoglycans (HSPGs) possess various functions driving malignancy of tumors. However, their impact on tumor cell sensitivity to cytotoxic treatment is far less understood. Aiming to investigate this, we depleted HSPGs by downregulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f622ef164479b0014d2b480e542baa6
https://doi.org/10.3390/ijms24065452
https://doi.org/10.3390/ijms24065452
Autor:
Viraj Doddihal, Carlos Guerrero-Hernández, Laurence Florens, Alejandro Sánchez Alvarado, Michaella J. Levy, Ekasit Sonpho, Frederick G. Mann, Eric D. Ross, Puey Ounjai, Anita Saraf
Publikováno v:
Molecular & Cellular Proteomics : MCP
The extracellular matrix (ECM) is a three-dimensional network of macromolecules that provides a microenvironment capable of supporting and regulating cell functions. However, only a few research organisms are available for the systematic dissection o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb97b36d5a16de5adc932446416d0e7f
http://europepmc.org/articles/PMC8503668
http://europepmc.org/articles/PMC8503668
Publikováno v:
Pharmacology & Therapeutics
The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has prompted scientists to address an urgent need for defining mechanisms of disease pathology and treatment. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9934ef0c6702914904ddd32cd943ffca
Autor:
Antonella, Bugatti, Francesca, Caccuri, Federica, Filippini, Cosetta, Ravelli, Arnaldo, Caruso
Publikováno v:
The Journal of Biological Chemistry
HIV-1 matrix protein p17 variants (vp17s) derived from non-Hodgkin's lymphoma (NHL) tissues of HIV-1–seropositive (HIV+) patients promote B-cell growth by activating the Akt signaling pathway. It is fundamental to understand the role played by vp17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::631593cc7d7f482ff1daf6b32dd3d9ca
https://pubmed.ncbi.nlm.nih.gov/34273353
https://pubmed.ncbi.nlm.nih.gov/34273353
Autor:
Kylie J. Schache, Kelli L. Sylvers-Davie, Ashley Segura-Roman, Brandon S.J. Davies, Alicia M. Salvi
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100112-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100112-(2021)
High plasma triglyceride (TG) levels and low HDL-C levels are risk factors for atherosclerosis and cardiovascular disease. Both plasma TG and HDL-C levels are regulated in part by the circulating inhibitor, angiopoietin-like 3 (ANGPTL3). ANGPTL3 inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea5d21cb024472b5e26f293bf72d1bb
https://pubmed.ncbi.nlm.nih.gov/34461133
https://pubmed.ncbi.nlm.nih.gov/34461133
Autor:
Alberto Carpinteiro Soares, Jonas Mariën, Edward B. Lee, John Q. Trojanowski, Charlotte Delay, Andreia Ferreira, Dieder Moechars, Louis De Muynck, Wim Annaert
Publikováno v:
The Journal of Biological Chemistry
Tauopathies, such as Alzheimer's disease (AD), are neurodegenerative disorders characterized by the deposition of hyperphosphorylated tau aggregates. Proteopathic tau seeds spread through the brain in a temporospatial pattern, indicative of transsyna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059fec311317b31ce0a89c1ba747e1e8
https://pubmed.ncbi.nlm.nih.gov/33831417
https://pubmed.ncbi.nlm.nih.gov/33831417