Výsledky vyhledávání - "HSPG, heparan sulfate proteoglycan"

Targeting glycan sulfation in a CD11c+ myeloid population inhibits early KRAS-mutant lung neoplasia1☆☆☆

Autor: Kim, So Young, Johns, Scott C., Gupta, Purva, Varki, Nissi, Fuster, Mark M

Publikováno v: Neoplasia (New York, N.Y.)

Early lung carcinoma development may be modulated by innate host cellular mechanisms that promote tumor growth and invasion. We recently identified how a loss-of-function mutation in the glycan sulfating enzyme N-deacetylase/N-sulfotransferase-1 (Nds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6c1a8c4e83557920ae120f81f6685b95
http://europepmc.org/articles/PMC8560828

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Functional Cellular Anti-Tumor Mechanisms are Augmented by Genetic Proteoglycan Targeting

Autor: Roland El Ghazal, So Young Kim, Scott C. Johns, Purva Gupta, Mark M. Fuster, Elina I. Zuniga

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 2, Pp 86-97 (2020)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.), vol 22, iss 2

While recent research points to the importance of glycans in cancer immunity, knowledge on functional mechanisms is lacking. In lung carcinoma among other tumors, anti-tumor immunity is suppressed; and while some recent therapies boost T-cell mediate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7e0acb8a762ad1ad8ad75a631c6062
http://www.sciencedirect.com/science/article/pii/S1476558619303045

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Slow diffusion on the monolayer culture enhances auto/paracrine effects of Noggin in differentiation of human iPS cells induced by BMP

Autor: Eri Nakatani, Riho Okajima, Kiyoshi Ohnuma

Publikováno v: Biochemistry and Biophysics Reports, Vol 29, Iss, Pp 101195-(2022)
Biochemistry and Biophysics Reports

Auto/paracrine factors secreted from cells affect differentiation of human pluripotent stem cells (hPSCs). However, the molecular mechanisms underlying the role of secreted factors are not well known. We previously showed that pattern formation in hP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a969c81eeb80b5d9ec90aadc4fd880
http://www.sciencedirect.com/science/article/pii/S2405580821002892

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Exostosin 1 Knockdown Induces Chemoresistance in MV3 Melanoma Cells by Upregulating JNK and MEK/ERK Signaling

Autor: Vladlena Pfeifer, Heiko Weber, Yuanyuan Wang, Martin Schlesinger, Christian Gorzelanny, Gerd Bendas

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5452

Heparan sulfate proteoglycans (HSPGs) possess various functions driving malignancy of tumors. However, their impact on tumor cell sensitivity to cytotoxic treatment is far less understood. Aiming to investigate this, we depleted HSPGs by downregulati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f622ef164479b0014d2b480e542baa6
https://doi.org/10.3390/ijms24065452

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Decellularization Enables Characterization and Functional Analysis of Extracellular Matrix in Planarian Regeneration

Autor: Viraj Doddihal, Carlos Guerrero-Hernández, Laurence Florens, Alejandro Sánchez Alvarado, Michaella J. Levy, Ekasit Sonpho, Frederick G. Mann, Eric D. Ross, Puey Ounjai, Anita Saraf

Publikováno v: Molecular & Cellular Proteomics : MCP

The extracellular matrix (ECM) is a three-dimensional network of macromolecules that provides a microenvironment capable of supporting and regulating cell functions. However, only a few research organisms are available for the systematic dissection o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb97b36d5a16de5adc932446416d0e7f
http://europepmc.org/articles/PMC8503668

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A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor

Autor: Murat Oz, Nadine Kabbani, Dietrich E. Lorke

Publikováno v: Pharmacology & Therapeutics

The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has prompted scientists to address an urgent need for defining mechanisms of disease pathology and treatment. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9934ef0c6702914904ddd32cd943ffca

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Binding to PI(4,5)P

Autor: Antonella, Bugatti, Francesca, Caccuri, Federica, Filippini, Cosetta, Ravelli, Arnaldo, Caruso

Publikováno v: The Journal of Biological Chemistry

HIV-1 matrix protein p17 variants (vp17s) derived from non-Hodgkin's lymphoma (NHL) tissues of HIV-1–seropositive (HIV+) patients promote B-cell growth by activating the Akt signaling pathway. It is fundamental to understand the role played by vp17

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::631593cc7d7f482ff1daf6b32dd3d9ca
https://pubmed.ncbi.nlm.nih.gov/34273353

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Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8

Autor: Kylie J. Schache, Kelli L. Sylvers-Davie, Ashley Segura-Roman, Brandon S.J. Davies, Alicia M. Salvi

Publikováno v: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100112-(2021)

High plasma triglyceride (TG) levels and low HDL-C levels are risk factors for atherosclerosis and cardiovascular disease. Both plasma TG and HDL-C levels are regulated in part by the circulating inhibitor, angiopoietin-like 3 (ANGPTL3). ANGPTL3 inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea5d21cb024472b5e26f293bf72d1bb
https://pubmed.ncbi.nlm.nih.gov/34461133

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