Zobrazeno 1 - 10
of 51
pro vyhledávání: '"HS - heparan sulfate"'
Autor:
Neb, Holger, Talbot, Steven Roger, Ruskowski, Katharina, Brkic, Djurdjina, Sonntagbauer, Michael, Adam, Elisabeth Hannah, Knethen, Andreas von, Zacharowski, Kai D., Heinicke, Ulrike
Publikováno v:
Shock. 58:514-523
Background: Severe progression of coronavirus disease 2019 (COVID-19) causes respiratory failure and critical illness. Recently, COVID-19 has been associated with heparanase (HPSE)-induced endothelial barrier dysfunction and inflammation, so called e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc65037b160ea7d241797a02b9eb3a7
https://doi.org/10.1097/shk.0000000000002021
https://doi.org/10.1097/shk.0000000000002021
Publikováno v:
Neoplasia (New York, N.Y.)
Early lung carcinoma development may be modulated by innate host cellular mechanisms that promote tumor growth and invasion. We recently identified how a loss-of-function mutation in the glycan sulfating enzyme N-deacetylase/N-sulfotransferase-1 (Nds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c1a8c4e83557920ae120f81f6685b95
http://europepmc.org/articles/PMC8560828
http://europepmc.org/articles/PMC8560828
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 2, Pp 86-97 (2020)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.), vol 22, iss 2
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.), vol 22, iss 2
While recent research points to the importance of glycans in cancer immunity, knowledge on functional mechanisms is lacking. In lung carcinoma among other tumors, anti-tumor immunity is suppressed; and while some recent therapies boost T-cell mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7e0acb8a762ad1ad8ad75a631c6062
http://www.sciencedirect.com/science/article/pii/S1476558619303045
http://www.sciencedirect.com/science/article/pii/S1476558619303045
Publikováno v:
The Journal of Biological Chemistry
Fibronectin (FN), an essential component of the extracellular matrix (ECM), is assembled via a cell-mediated process in which integrin receptors bind secreted FN and mediate its polymerization into fibrils that extend between cells, ultimately formin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a814e97b6c25bd5dfe573021712f6e7
http://europepmc.org/articles/PMC8801470
http://europepmc.org/articles/PMC8801470
Autor:
Heriberto Moran, Limary M. Cancel, Peigen Huang, Sylvie Roberge, Tuoye Xu, John M. Tarbell, Lance L. Munn
Publikováno v:
Matrix Biology Plus
Matrix Biology Plus, Vol 13, Iss, Pp 100100-(2022)
Matrix Biology Plus, Vol 13, Iss, Pp 100100-(2022)
Highlights • Mechanotransduction through cell surface GAGs is a potential driver of metastasis. • SAHA, a histone deacetylase inhibitor, reduces tumor cell NDST1 and HS. • SAHA blocked metastasis of highly metastatic renal carcinoma cells in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6554547f15ec2891cde433f14b3369c9
https://pubmed.ncbi.nlm.nih.gov/35106474
https://pubmed.ncbi.nlm.nih.gov/35106474
Autor:
Michelle A. Ozbun
Publikováno v:
Papillomavirus Research
Papillomavirus Research, Vol 7, Iss, Pp 188-192 (2019)
Papillomavirus Research, Vol 7, Iss, Pp 188-192 (2019)
Human papillomaviruses (HPVs), like all PVs, predominantly cause benign tumors, or warts, in stratifying squamous epithelial tissues. Virions are released from apical surfaces of the skin and mucosa and, to initiate a new infection, must utilize a br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7251c6de935a25473ff8355606a1b347
http://europepmc.org/articles/PMC6514438
http://europepmc.org/articles/PMC6514438
Publikováno v:
Pharmacology & Therapeutics
The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has prompted scientists to address an urgent need for defining mechanisms of disease pathology and treatment. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9934ef0c6702914904ddd32cd943ffca
Publikováno v:
The Journal of Biological Chemistry
The retention of low-density lipoprotein (LDL) is a key process in the pathogenesis of atherosclerosis and largely mediated via smooth-muscle cell-derived extracellular proteoglycans including the glycosaminoglycan chains. Macrophages can also intern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f44863a452d05207d3dfdac6be8261
http://europepmc.org/articles/PMC8027565
http://europepmc.org/articles/PMC8027565
Autor:
Masanobu Morita, Yu Yamaguchi, Fumitoshi Irie, Yu Mei, Ai Shimane, Kazuhiko Yanai, Takeo Yoshikawa, Rina Otsuka, Takuro Matsuzawa
Publikováno v:
The Journal of Biological Chemistry
Heparan sulfate (HS), a highly sulfated linear polysaccharide, is involved in diverse biological functions in various tissues. Although previous studies have suggested a possible contribution of HS to the differentiation of white adipocytes, there ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96a1800166fbc18d437ce1e6f65a7f4
https://pubmed.ncbi.nlm.nih.gov/34310946
https://pubmed.ncbi.nlm.nih.gov/34310946
Autor:
Bin Deng, Cong Wang, Yu Zhang, Mitchell A. Sullivan, Hanxiang Wang, Chen Shi, Wu Tingting, Jin-Ping Li
Publikováno v:
Carbohydrate Polymers
Highlights • Heparin, used clinically over 80 years, has shown potential for COVID-19 treatment. • The evidence and possible mechanisms of heparin for COVID-19 treatment are discussed. • The prospect of heparin therapy for COVID-19 is presented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea41a753fc87fb156c8459e32433f4d