Výsledky vyhledávání - "HS

Heparan sulfate (HS)/heparan sulfate proteoglycan (HSPG) and bikunin are up-regulated during calcium oxalate nephrolithiasis in rat kidney

Autor: Michiro Inoue, Yoshiro Eguchi, Shinshi Noda, Kei Matsuoka, Shizuka Iida

Publikováno v: The Kurume medical journal. 49(3)

We reported that expression of both HSPG and of bikunin are increased in calcium oxalate (CaOx) nephrolithic rat kidneys (lida et al., J. Am. Soc. Nephrol. 1999, Urol. Res. 1997). However, these findings were obtained from separate experiments. The p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93262ec703bca5599f207dee089b46f5
https://pubmed.ncbi.nlm.nih.gov/12471724

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HIGH HEPARANASE LEVEL IN SURVIVORS OF COVID-19 — INDICATOR OF VASCULAR AND PULMONARY RECOVERY?

Autor: Neb, Holger, Talbot, Steven Roger, Ruskowski, Katharina, Brkic, Djurdjina, Sonntagbauer, Michael, Adam, Elisabeth Hannah, Knethen, Andreas von, Zacharowski, Kai D., Heinicke, Ulrike

Publikováno v: Shock. 58:514-523

Background: Severe progression of coronavirus disease 2019 (COVID-19) causes respiratory failure and critical illness. Recently, COVID-19 has been associated with heparanase (HPSE)-induced endothelial barrier dysfunction and inflammation, so called e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc65037b160ea7d241797a02b9eb3a7
https://doi.org/10.1097/shk.0000000000002021

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Targeting glycan sulfation in a CD11c+ myeloid population inhibits early KRAS-mutant lung neoplasia1☆☆☆

Autor: Kim, So Young, Johns, Scott C., Gupta, Purva, Varki, Nissi, Fuster, Mark M

Publikováno v: Neoplasia (New York, N.Y.)

Early lung carcinoma development may be modulated by innate host cellular mechanisms that promote tumor growth and invasion. We recently identified how a loss-of-function mutation in the glycan sulfating enzyme N-deacetylase/N-sulfotransferase-1 (Nds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6c1a8c4e83557920ae120f81f6685b95
http://europepmc.org/articles/PMC8560828

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Functional Cellular Anti-Tumor Mechanisms are Augmented by Genetic Proteoglycan Targeting

Autor: Roland El Ghazal, So Young Kim, Scott C. Johns, Purva Gupta, Mark M. Fuster, Elina I. Zuniga

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 2, Pp 86-97 (2020)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.), vol 22, iss 2

While recent research points to the importance of glycans in cancer immunity, knowledge on functional mechanisms is lacking. In lung carcinoma among other tumors, anti-tumor immunity is suppressed; and while some recent therapies boost T-cell mediate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7e0acb8a762ad1ad8ad75a631c6062
http://www.sciencedirect.com/science/article/pii/S1476558619303045

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Heparan sulfate is necessary for the early formation of nascent fibronectin and collagen I fibrils at matrix assembly sites

Autor: Katherine E. Hill, Benjamin M. Lovett, Jean E. Schwarzbauer

Publikováno v: The Journal of Biological Chemistry

Fibronectin (FN), an essential component of the extracellular matrix (ECM), is assembled via a cell-mediated process in which integrin receptors bind secreted FN and mediate its polymerization into fibrils that extend between cells, ultimately formin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a814e97b6c25bd5dfe573021712f6e7
http://europepmc.org/articles/PMC8801470

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Glycocalyx mechanotransduction mechanisms are involved in renal cancer metastasis

Autor: Heriberto Moran, Limary M. Cancel, Peigen Huang, Sylvie Roberge, Tuoye Xu, John M. Tarbell, Lance L. Munn

Publikováno v: Matrix Biology Plus
Matrix Biology Plus, Vol 13, Iss, Pp 100100-(2022)

Highlights • Mechanotransduction through cell surface GAGs is a potential driver of metastasis. • SAHA, a histone deacetylase inhibitor, reduces tumor cell NDST1 and HS. • SAHA blocked metastasis of highly metastatic renal carcinoma cells in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6554547f15ec2891cde433f14b3369c9
https://pubmed.ncbi.nlm.nih.gov/35106474

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Extracellular events impacting human papillomavirus infections: Epithelial wounding to cell signaling involved in virus entry

Autor: Michelle A. Ozbun

Publikováno v: Papillomavirus Research
Papillomavirus Research, Vol 7, Iss, Pp 188-192 (2019)

Human papillomaviruses (HPVs), like all PVs, predominantly cause benign tumors, or warts, in stratifying squamous epithelial tissues. Virions are released from apical surfaces of the skin and mucosa and, to initiate a new infection, must utilize a br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7251c6de935a25473ff8355606a1b347
http://europepmc.org/articles/PMC6514438

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A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor

Autor: Murat Oz, Nadine Kabbani, Dietrich E. Lorke

Publikováno v: Pharmacology & Therapeutics

The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has prompted scientists to address an urgent need for defining mechanisms of disease pathology and treatment. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2

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