Zobrazeno 1 - 10
of 3 081
pro vyhledávání: '"HRAS"'
Autor:
Salar Saadi Dizayee
Publikováno v:
Zanco Journal of Medical Sciences, Vol 28, Iss 2, Pp 292-300 (2024)
Background and objective: RAS gene mutations, including Harvey RAS, are a biomarker in studying many types of cancer, including colorectal cancer. Studying the molecular and mutations of the HRAS gene help in understanding the nature of the tumor and
Externí odkaz:
https://doaj.org/article/64016c2c076045cc8cad7e56edf38b18
Autor:
Praveen Guruvaiah, Romi Gupta
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Oncogenic mutations in the RAS gene are associated with uncontrolled cell growth, a hallmark feature contributing to tumorigenesis. While diverse therapeutic strategies have been diligently applied to treat RAS-mutant cancers, suc
Externí odkaz:
https://doaj.org/article/ad4809f736484197a181c829b8bf3a50
Publikováno v:
Cell Division, Vol 19, Iss 1, Pp 1-13 (2024)
Abstract Nitrogen permease regulator-like 2 (NPRL2/TUSC4) is known to exert both tumor-suppressing and oncogenic effects in different types of cancers, suggesting that its actions are context dependent. Here, we delineated the molecular and functiona
Externí odkaz:
https://doaj.org/article/ff5d7e7199d949a8aa0332b54ea9d28f
Autor:
Rocío Fuentes-Mateos, Rósula García-Navas, Cristina Fernández-Infante, Luis Hernández-Cano, Nuria Calzada-Nieto, Andrea Olarte-San Juan, Carmen Guerrero, Eugenio Santos, Alberto Fernández-Medarde
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background HRASKO/NRASKO double knockout mice exhibit exceedingly high rates of perinatal lethality due to respiratory failure caused by a significant lung maturation delay. The few animals that reach adulthood have a normal lifespan, but pr
Externí odkaz:
https://doaj.org/article/714ac511d89a47b0b3bd77f52a9215b0
Autor:
Santiago Peralta, Boaz Arzi
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/fe02d39bd8584e9fa084082663d8a179
Autor:
Swarang Sachin Pundlik, Alok Barik, Ashwin Venkateshvaran, Snehasudha Subhadarshini Sahoo, Mahapatra Anshuman Jaysingh, Raviswamy GH Math, Heera Lal, Maroof Athar Hashmi, Arvind Ramanathan
Publikováno v:
eLife, Vol 13 (2024)
Senescent cells are characterized by multiple features such as increased expression of senescence-associated β-galactosidase activity (SA β-gal) and cell cycle inhibitors such as p21 or p16. They accumulate with tissue damage and dysregulate tissue
Externí odkaz:
https://doaj.org/article/4b26cba46b57456e9cf1be5ddfbddafb
Autor:
Isaac Silverman, Michael Gerber, Aaron Shaykevich, Yitzchak Stein, Alexander Siegman, Sanjay Goel, Radhashree Maitra
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
The RAS genes which code for KRAS, HRAS, and NRAS are three of the most frequently mutated oncogenes responsible for cancer deaths. Tumorigenesis is one of the most significant outcomes of deregulation of RAS GTPases. Although the structures have bee
Externí odkaz:
https://doaj.org/article/6481bb380a4948d9adcd0c40198428e7
Autor:
Chenxin Xu, Guoyu Chen, Bo Yu, Bowen Sun, Yingwen Zhang, Mingda Zhang, Yi Yang, Yichuan Xiao, Shi‐Yuan Cheng, Yanxin Li, Haizhong Feng
Publikováno v:
Advanced Science, Vol 11, Iss 29, Pp n/a-n/a (2024)
Abstract The factors driving glioma progression remain poorly understood. Here, the epigenetic regulator TRIM24 is identified as a driver of glioma progression, where TRIM24 overexpression promotes HRasV12 anaplastic astrocytoma (AA) progression into
Externí odkaz:
https://doaj.org/article/4533c20a70e64f66876871ae4421263b
Autor:
Dou, Rui1,2, Zhang, Lili1, Lu, Tingxia3, Liu, Dong1, Mei, Fang4, Huang, Jian3, Qian, Linxue1 qianlinxue2002@163.com
Publikováno v:
Oncology Letters. Apr2018, Vol. 15 Issue 4, p4511-4516. 7p.
Publikováno v:
BMC Pediatrics, Vol 23, Iss 1, Pp 1-5 (2023)
Abstract Background Costello syndrome (CS) is a rare genetic condition characterized by dysregulation of the signaling pathway, phenotypic alteration due to fetal macrosomia or growth retardation, facial abnormalities, loose skin, cardiovascular abno
Externí odkaz:
https://doaj.org/article/fb604741c32647f787804d02ae29c8a1