Zobrazeno 1 - 10
of 611
pro vyhledávání: '"HPSC"'
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Ion channels in retinal pigment epithelial (RPE) cells are crucial for retinal health and vision functions. Defects in such channels are intricately associated with the development of various retinopathies that cause blindness. Human pluripo
Externí odkaz:
https://doaj.org/article/c8404e1721c1479cb73e2fe4f4d39340
Autor:
Ingrid Wilhelmsen, Thomas Combriat, Andrea Dalmao-Fernandez, Justyna Stokowiec, Chencheng Wang, Petter Angell Olsen, Jonas Aakre Wik, Yuliia Boichuk, Aleksandra Aizenshtadt, Stefan Krauss
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background Hepatic stellate cells (HSC) have numerous critical roles in liver function and homeostasis, while they are also known for their importance during liver injury and fibrosis. There is therefore a need for relevant in vitro human HS
Externí odkaz:
https://doaj.org/article/dbbe1592310a4cfd8a57b7b979f5324e
Autor:
Nils Kriedemann, Felix Manstein, Carlos A. Hernandez-Bautista, Kevin Ullmann, Wiebke Triebert, Annika Franke, Mira Mertens, Inês Carvalheira Arnaut Pombeiro Stein, Andreas Leffler, Merlin Witte, Tamari Askurava, Veronika Fricke, Ina Gruh, Birgit Piep, Kathrin Kowalski, Theresia Kraft, Robert Zweigerdt
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background Commonly used media for the differentiation of human pluripotent stem cells into cardiomyocytes (hPSC-CMs) contain high concentrations of proteins, in particular albumin, which is prone to quality variations and presents a substan
Externí odkaz:
https://doaj.org/article/c071a733e7104321b7fcea2933e63725
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 4, Pp 151452- (2024)
Cardiac development requires precise gene expression programs at each developmental stage guided by multiple signaling pathways and transcription factors (TFs). MESP1 is transiently expressed in mesoderm, and is essential for subsequent cardiac devel
Externí odkaz:
https://doaj.org/article/f702bd33ac9f4979afedd1e09732eb3b
Autor:
Xing Zhen, Jieun Kim, Jong Soon Kang, Byeong Jo Choi, Ki Hwan Park, Dong-Seok Lee, Seok-Ho Hong, Jong-Hee Lee
Publikováno v:
EBioMedicine, Vol 109, Iss , Pp 105390- (2024)
Summary: Background: Macrophages engineered with chimeric antigen receptors (CAR) are suitable for immunotherapy based on their immunomodulatory activity and ability to infiltrate solid tumours. However, the production and application of genetically
Externí odkaz:
https://doaj.org/article/f07148f0a4c5489c87f80fc2500cd70a
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Background In vitro disease modeling enables translational research by providing insight into disease pathophysiology and molecular mechanisms, leading to the development of novel therapeutics. Nevertheless, in vitro systems have limitations
Externí odkaz:
https://doaj.org/article/8b1331897aa947a7a5d5ea4789adae89
Autor:
Jonas Van Lent, Arianna Baggiolini
Publikováno v:
Molecular Oncology, Vol 18, Iss 4, Pp 793-796 (2024)
When we think about cancer, the link to development might not immediately spring to mind. Yet, many foundational concepts in cancer biology trace their roots back to developmental processes. Several defining traits of cancer were indeed initially obs
Externí odkaz:
https://doaj.org/article/526e45c78644459fb2887e33ba79f5dc
Autor:
Hana Lee, Seunghye Yang, Kyung Jin Lee, Si-Na Kim, Ji-Seon Jeong, Ki Young Kim, Cho-Rok Jung, Sooyeon Jeon, Dayeon Kwon, Sungin Lee, Hanbyeol Lee, Chihye Park, Sun-Ju Ahn, Jongman Yoo, Mi-Young Son
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
To enhance the practical application of intestinal organoids, it is imperative to establish standardized guidelines. This proposed standardization outlines a comprehensive framework to ensure consistency and reliability in the development, characteri
Externí odkaz:
https://doaj.org/article/6f8429ed52b1417d9369cf32af300863
Autor:
Abhimanyu Thakur, Shuya Mei, Noel Zhang, Kui Zhang, Boghos Taslakjian, Jiacee Lian, Shuang Wu, Bohao Chen, Julian Solway, Huanhuan Joyce Chen
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Pulmonary neuroendocrine cells (PNECs) are unique airway epithelial cells that blend neuronal and endocrine functions, acting as key sensors in the lung. They respond to environmental stimuli like allergens by releasing neuropeptides and neurotransmi
Externí odkaz:
https://doaj.org/article/35c4a523768f47568f6563a298b6d784
Autor:
Kevin Ullmann, Felix Manstein, Wiebke Triebert, Nils Kriedemann, Annika Franke, Jana Teske, Mira Mertens, Victoria Lupanow, Gudrun Göhring, Alexandra Haase, Ulrich Martin, Robert Zweigerdt
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Background Human pluripotent stem cells (hPSCs) have an enormous therapeutic potential, but large quantities of cells will need to be supplied by reliable, economically viable production processes. The suspension culture (three-dimensional;
Externí odkaz:
https://doaj.org/article/68aa172d3c3c41398fe5f1d1b2655b03