Zobrazeno 1 - 10
of 68
pro vyhledávání: '"HP1γ"'
Autor:
Yao Xiang, Jorge Mata-Garrido, Yuanji Fu, Christophe Desterke, Eric Batsché, Ahmed Hamaï, Christine Sedlik, Youssouf Sereme, David Skurnik, Abdelali Jalil, Rachel Onifarasoaniaina, Eric Frapy, Jean-Christophe Beche, Razack Alao, Eliane Piaggio, Laurence Arbibe, Yunhua Chang
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1404-1426 (2024)
Abstract As an important immune stimulator and modulator, IFNγ is crucial for gut homeostasis and its dysregulation links to diverse colon pathologies, such as colitis and colorectal cancer (CRC). Here, we demonstrated that the epigenetic regulator,
Externí odkaz:
https://doaj.org/article/de2e44b1297c4b6381469b61856d34e2
Akademický článek
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Autor:
Jorge Mata-Garrido, Laura Frizzi, Thien Nguyen, Xiangyan He, Yunhua Chang-Marchand, Yao Xiang, Caroline Reisacher, Iñigo Casafont, Laurence Arbibe
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7347 (2023)
Chronic inflammatory processes in the intestine result in serious conditions such as inflammatory bowel disease (IBD) and cancer. An increased detection of cytoplasmic DNA sensors has been reported in the IBD colon mucosa, suggesting their contributi
Externí odkaz:
https://doaj.org/article/af20f9fa78fd4eaca5993a9c6bca71c4
Autor:
Kyohei Oyama, Danny El-Nachef, Chen Fang, Hidemi Kajimoto, Jeremy P. Brown, Prim B. Singh, W. Robb MacLellan
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-15 (2018)
Abstract Background Heterochromatin, which is formed when tri-methyl lysine 9 of histone H3 (H3K9me3) is bound by heterochromatin 1 proteins (HP1s), plays an important role in differentiation and senescence by silencing cell cycle genes. Cardiac myoc
Externí odkaz:
https://doaj.org/article/a8976ee3773e4a23bd563d67ccc34511
Autor:
Laia Bosch-Presegué, Helena Raurell-Vila, Joshua K. Thackray, Jessica González, Carmen Casal, Noriko Kane-Goldsmith, Miguel Vizoso, Jeremy P. Brown, Antonio Gómez, Juan Ausió, Timo Zimmermann, Manel Esteller, Gunnar Schotta, Prim B. Singh, Lourdes Serrano, Alejandro Vaquero
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2048-2057 (2017)
HP1 is a structural component of heterochromatin. Mammalian HP1 isoforms HP1α, HP1β, and HP1γ play different roles in genome stability, but their precise role in heterochromatin structure is unclear. Analysis of Hp1α−/−, Hp1β−/−, and Hp1
Externí odkaz:
https://doaj.org/article/b92ca1c79844433cb1579b663e305b5b
Autor:
Helena Raurell-Vila, Laia Bosch-Presegue, Jessica Gonzalez, Noriko Kane-Goldsmith, Carmen Casal, Jeremy P. Brown, Anna Marazuela-Duque, Prim B. Singh, Lourdes Serrano, Alejandro Vaquero
Publikováno v:
Epigenetics, Vol 12, Iss 2, Pp 166-175 (2017)
The presence of H3K9me3 and heterochromatin protein 1 (HP1) are hallmarks of heterochromatin conserved in eukaryotes. The spreading and maintenance of H3K9me3 is effected by the functional interplay between the H3K9me3-specific histone methyltransfer
Externí odkaz:
https://doaj.org/article/694434165b7c4695aea2ecf82b829910
Akademický článek
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Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 5976 (2020)
Cisplatin is the most frequently used agent for chemotherapy against cervical cancer. However, recurrent use of cisplatin induces resistance, representing a major hurdle in the treatment of cervical cancer. Our previous study revealed that HP1γ supp
Externí odkaz:
https://doaj.org/article/d8f7f23e8e7b4060a435fe32962d5b90
Akademický článek
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Autor:
Roland K. Hartmann, Achim Aigner, Arnold Grünweller, Dennis Streng, Julia Schlereth, Lara Golde, Kerstin Lange-Grünweller, Dorothee Hartmann, Maren Thomas
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 6, Pp 12273-12296 (2013)
The human polycistronic miRNA cluster miR-17-92 is frequently overexpressed in hematopoietic malignancies and cancers. Its transcription is in part controlled by an E2F-regulated host gene promoter. An intronic A/T-rich region directly upstream of th
Externí odkaz:
https://doaj.org/article/51e89e0db5134062aee2e5938f0c7ee9