Robust and persistent B-cell responses following SARS-CoV-2 vaccine determine protection from SARS-CoV-2 infection

Autor: Joanne Byrne, Lili Gu, Alejandro Garcia-Leon, Colette Marie Gaillard, Gurvin Saini, Dana Alalwan, Julen Tomás-Cortázar, Grace Kenny, Sean Donohue, Bearach Reynolds, Tessa O’Gorman, Alan Landay, Peter Doran, Jannik Stemler, Philipp Koehler, Rebecca Jane Cox, Ole F. Olesen, Jean-Daniel Lelievre, Cathal O’Broin, Stefano Savinelli, Eoin R. Feeney, Jane A. O’Halloran, Aoife Cotter, Mary Horgan, Christine Kelly, Corrina Sadlier, Eoghan de Barra, Oliver A. Cornely, Virginie Gautier, Patrick WG Mallon, All Ireland Infectious Diseases cohort study and VACCELERATE consortium, A. Cotter, E. Muldoon, G. Sheehan, T. McGinty, J. S. Lambert, T. O’Gorman, C. Kelly, K. Leamy, J. Byrne, G. Kenny, K. McCann, R. McCann, C. O’Broin, S. Savinelli, J. O’Halloran, E. Feeney, P. W. G. Mallon, A. Garcia Leon, S. Miles, D. Alalwan, R. Negi, G. Saini, E. Moore, E. de Barra, S. McConkey, K. Hurley, B. Jacob, F. Lyons, M. Horgan, C. Sadlier, T. Bracken, B. Whelan, J Low, O Yousif, B. McNicholas, G. Courtney, C. O’Maoldomhnaigh, P. Gavin, Julia M. Neuhann, Ullrich Bethe, Sarah Heringer, Jon Salmanton-Garcı́a, Lea Tischmann, Arnd Cüppers, Jan Grothe, Antonio J. Carcas, Jesús Frías-Iniesta, Murat Akova, Alejandro Garcia Leon, Patrick Mallon, Riya Negi, Colette Gaillard, Christine Lammens, An Hotterbeekx, Katherine Loens, Surbhi Malhotra-Kumar, Herman Goossens, Samir Kumar-Singh, Franz König, Lusine Yeghiazaryan, Martin Posch

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionA clear immune correlate of protection from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has not been defined. We explored antibody, B-cell, and T-cell responses to the third-dose vaccine and relationship to inci

Externí odkaz: https://doaj.org/article/1469edd2e8884d0ab79ea55f12a635fa

Immunogenicity, reactogenicity, and safety of a second booster with BNT162b2 or full-dose mRNA-1273: A randomized VACCELERATE trial in adults aged ≥75 years (EU-COVAT-1-AGED Part B)

Autor: Stemler, Jannik, Yeghiazaryan, Lusine, Stephan, Christoph, Mohn, Kristin Greve-Isdahl, Carcas-Sansuan, Antonio-José, Rodriguez, Esperanza Romero, Moltó, José, Mitxeltorena, Itziar Vergara, Welte, Tobias, Zablockienė, Birutė, Akova, Murat, Bethe, Ullrich, Heringer, Sarah, Salmanton-García, Jon, Jeck, Julia, Tischmann, Lea, Zarrouk, Marouan, Cüppers, Arnd, Biehl, Lena M., Grothe, Jan, Mellinghoff, Sibylle C., Nacov, Julia A., Neuhann, Julia M., Sprute, Rosanne, Frías-Iniesta, Jesús, Negi, Riya, Gaillard, Colette, Saini, Gurvin, León, Alejandro García, Mallon, Patrick W.G., Lammens, Christine, Hotterbeekx, An, Loens, Katherine, Malhotra-Kumar, Surbhi, Goossens, Herman, Kumar-Singh, Samir, König, Franz, Posch, Martin, Koehler, Philipp, Cornely, Oliver A.

Publikováno v: In International Journal of Infectious Diseases September 2024 146

Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort

Autor: Pinho Guedes, Mariana Nunes, Maccarrone, Gaia, Pezzani, Maria Diletta, Sibani, Marcella, Davies, Ruth Joanna, Vitali, Stefania, Franchina, Giorgia, Tomassini, Giorgia, Sciammarella, Concetta, Cecchetto, Riccardo, Gibellini, Davide, De Toffoli, Chiara Konishi, Rosini, Giulia, Perlini, Chiara, Meroi, Marco, Cioli Puviani, Filippo, Fasan, Daniele, Micheletto, Claudio, Montemezzi, Stefania, Cardobi, Nicolò, Vantini, Gianluca, Mazzali, Gloria, Stabile, Giovanni, Marcanti, Maddalena, Zonta, Marco Pattaro, Calì, Deborah, Mason, Anna, Perlini, Cinzia, Gisondi, Paolo, Mongardi, Maria, Sorbello, Simona, Wold, Karin I., Vincenti-González, María F., Veloo, Alida C.M., Harmsma, Valerie P.R., Pantano, Daniele, van der Meer, Margriet, Gard, Lilli, Lizarazo, Erley F., Knoester, Marjolein, Friedrich, Alex W., Niesters, Hubert G.M., Viale, Pierluigi, Marzolla, Domenico, Cosentino, Federica, Di Chiara, Michela, Fornaro, Giacomo, Bonazzetti, Cecilia, Tazza, Beatrice, Toschi, Alice, Vetamanu, Oana, Giacomini, Maria Eugenia, Trapani, Fabio, Marconi, Lorenzo, Attard, Luciano, Tedeschi, Sara, Gabrielli, Liliana, Lazzarotto, Tiziana, Olivares, Paula, Castilla, Javier, Vélez, Javier, Almadana, Virginia, Martín-Barrera, Lucía, Martín-Gutiérrez, Ana Belén, Gutiérrez-Campos, David, Fernández-Regaña, Marta, Silva-Campos, Ana, Fernández-Riejos, Patricia, García-Sánchez, M. Isabel, Giuliano, Carla V., López, Carlota, Neumann, Gabriela, Camporro, Julieta, de Vedia, Lautaro, Agugliaro, Hugo, Scipione, Gabriella, Dellacasa, Chiara, Chandramouli, Balasubramanian, Gioiosa, Silvia, Naranjo, Juan Mata, Ortali, Maurizio, Konnova, Angelina, Gupta, Akshita, Smet, Mathias, Hotterbeekx, An, Berkell, Matilda, Sicuri, Elisa, Bachelet, Delphine, Bouadma, Lila, Cervantes-Gonzalez, Minerva, Chair, Anissa, Charpentier, Charlotte, Chenard, Léo, Descamps, Diane, Doan, Hang, Duval, Xavier, Esposito-Farese, Marina, Hoffmann, Isabelle, Kafif, Ouifiya, Le Hingrat, Quentin, Letrou, Sophie, Mentré, France, Schneider, Marion, Tardivon, Coralie, Timsit, Jean-Francois, Tubiana, Sarah, Abrous, Amal, Couffin-Cadiergues, Sandrine, Da Silva, Fernanda Dias, Esperou, Hélène, Houas, Ikram, Jaafoura, Salma, Papadopoulos, Aurélie, Ansart, Severine, Auvet, Adrien, Bani-Sadr, Firouzé, Bernard, L., Bissuel, François, Botelho-Nevers, Elisabeth, Bouhour, Damien, Cabié, André, Caraux Paz, Pauline, Chidiac, Christian, Chirouze, Catherine, Chroboczek, Tomasz, Cordel, Hugues, Courtois, Roxane, De Castro, Nathalie, Diamamntis, Sylvain, Diehl, Jean-Luc, Djossou, Felix, Dorival, Céline, Epaulard, Olivier, Gaborieau, Valerie, Goehringer, François, Gousseff, Marie, Jamard, Simon, Joseph, Cedric, Lacombe, Karine, Le Mestre, Soizic, Le Moing, Vincent, Lelievre, Jean-Daniel, Lesens, Olivier, Machado, M., Maillet, Mylène, Manda, Victoria, Martin-Blondel, Guillaume, Martinot, Martin, Meysonnier, Vanina, Molina, Jean-Michel, Oziol, Eric, Pestre, Vincent, Piroth, Lionel, Poissy, Julien, Rabaud, Christian, Raffi, François, Rammaert, Blandine, Rapp, Christophe, Rebaudet, Stanislas, Roger, Pierre-Marie, Roux, Damien, Senneville, Eric, Tattevin, Pierre, Wiedemann, Aurélie, Zucman, David, Gentilotti, Elisa, Górska, Anna, Tami, Adriana, Gusinow, Roy, Mirandola, Massimo, Rodríguez Baño, Jesús, Palacios Baena, Zaira R., Rossi, Elisa, Hasenauer, Jan, Lopes-Rafegas, Iris, Righi, Elda, Caroccia, Natascia, Cataudella, Salvatore, Pasquini, Zeno, Osmo, Thomas, Del Piccolo, Lidia, Savoldi, Alessia, Kumar-Singh, Samir, Mazzaferri, Fulvia, Caponcello, Maria Giulia, de Boer, Gerolf, Hara, Gabriel Levy, De Nardo, Pasquale, Malhotra, Surbhi, Canziani, Lorenzo Maria, Ghosn, Jade, Florence, Aline-Marie, Lafhej, Nadhem, van der Gun, Bernardina T.F., Giannella, Maddalena, Laouénan, Cédric, Tacconelli, Evelina

Publikováno v: In eClinicalMedicine August 2023 62

Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohortResearch in context

Autor: Elisa Gentilotti, Anna Górska, Adriana Tami, Roy Gusinow, Massimo Mirandola, Jesús Rodríguez Baño, Zaira R. Palacios Baena, Elisa Rossi, Jan Hasenauer, Iris Lopes-Rafegas, Elda Righi, Natascia Caroccia, Salvatore Cataudella, Zeno Pasquini, Thomas Osmo, Lidia Del Piccolo, Alessia Savoldi, Samir Kumar-Singh, Fulvia Mazzaferri, Maria Giulia Caponcello, Gerolf de Boer, Gabriel Levy Hara, Pasquale De Nardo, Surbhi Malhotra, Lorenzo Maria Canziani, Jade Ghosn, Aline-Marie Florence, Nadhem Lafhej, Bernardina T.F. van der Gun, Maddalena Giannella, Cédric Laouénan, Evelina Tacconelli, Mariana Nunes Pinho Guedes, Gaia Maccarrone, Maria Diletta Pezzani, Marcella Sibani, Ruth Joanna Davies, Stefania Vitali, Giorgia Franchina, Giorgia Tomassini, Concetta Sciammarella, Riccardo Cecchetto, Davide Gibellini, Chiara Konishi De Toffoli, Giulia Rosini, Chiara Perlini, Marco Meroi, Filippo Cioli Puviani, Daniele Fasan, Claudio Micheletto, Stefania Montemezzi, Nicolò Cardobi, Gianluca Vantini, Gloria Mazzali, Giovanni Stabile, Maddalena Marcanti, Marco Pattaro Zonta, Deborah Calì, Anna Mason, Cinzia Perlini, Paolo Gisondi, Maria Mongardi, Simona Sorbello, Karin I. Wold, María F. Vincenti-González, Alida C.M. Veloo, Valerie P.R. Harmsma, Daniele Pantano, Margriet van der Meer, Lilli Gard, Erley F. Lizarazo, Marjolein Knoester, Alex W. Friedrich, Hubert G.M. Niesters, Pierluigi Viale, Domenico Marzolla, Federica Cosentino, Michela Di Chiara, Giacomo Fornaro, Cecilia Bonazzetti, Beatrice Tazza, Alice Toschi, Oana Vetamanu, Maria Eugenia Giacomini, Fabio Trapani, Lorenzo Marconi, Luciano Attard, Sara Tedeschi, Liliana Gabrielli, Tiziana Lazzarotto, Paula Olivares, Javier Castilla, Javier Vélez, Virginia Almadana, Lucía Martín-Barrera, Ana Belén Martín-Gutiérrez, David Gutiérrez-Campos, Marta Fernández-Regaña, Ana Silva-Campos, Patricia Fernández-Riejos, M. Isabel García-Sánchez, Carla V. Giuliano, Carlota López, Gabriela Neumann, Julieta Camporro, Lautaro de Vedia, Hugo Agugliaro, Gabriella Scipione, Chiara Dellacasa, Balasubramanian Chandramouli, Silvia Gioiosa, Juan Mata Naranjo, Maurizio Ortali, Angelina Konnova, Akshita Gupta, Mathias Smet, An Hotterbeekx, Matilda Berkell, Elisa Sicuri, Delphine Bachelet, Lila Bouadma, Minerva Cervantes-Gonzalez, Anissa Chair, Charlotte Charpentier, Léo Chenard, Diane Descamps, Hang Doan, Xavier Duval, Marina Esposito-Farese, Isabelle Hoffmann, Ouifiya Kafif, Quentin Le Hingrat, Sophie Letrou, France Mentré, Marion Schneider, Coralie Tardivon, Jean-Francois Timsit, Sarah Tubiana, Amal Abrous, Sandrine Couffin-Cadiergues, Fernanda Dias Da Silva, Hélène Esperou, Ikram Houas, Salma Jaafoura, Aurélie Papadopoulos, Severine Ansart, Adrien Auvet, Firouzé Bani-Sadr, L. Bernard, François Bissuel, Elisabeth Botelho-Nevers, Damien Bouhour, André Cabié, Pauline Caraux Paz, Christian Chidiac, Catherine Chirouze, Tomasz Chroboczek, Hugues Cordel, Roxane Courtois, Nathalie De Castro, Sylvain Diamamntis, Jean-Luc Diehl, Felix Djossou, Céline Dorival, Olivier Epaulard, Valerie Gaborieau, François Goehringer, Marie Gousseff, Simon Jamard, Cedric Joseph, Karine Lacombe, Soizic Le Mestre, Vincent Le Moing, Jean-Daniel Lelievre, Olivier Lesens, M. Machado, Mylène Maillet, Victoria Manda, Guillaume Martin-Blondel, Martin Martinot, Vanina Meysonnier, Jean-Michel Molina, Eric Oziol, Vincent Pestre, Lionel Piroth, Julien Poissy, Christian Rabaud, François Raffi, Blandine Rammaert, Christophe Rapp, Stanislas Rebaudet, Pierre-Marie Roger, Damien Roux, Eric Senneville, Pierre Tattevin, Aurélie Wiedemann, David Zucman

Publikováno v: EClinicalMedicine, Vol 62, Iss , Pp 102107- (2023)

Summary: Background: Lack of specific definitions of clinical characteristics, disease severity, and risk and preventive factors of post-COVID-19 syndrome (PCS) severely impacts research and discovery of new preventive and therapeutics drugs. Methods

Externí odkaz: https://doaj.org/article/22600d8ef9254da88af1d1e9de66fe78

Host immunological responses facilitate development of SARS-CoV-2 mutations in patients receiving monoclonal antibody treatments

Autor: Akshita Gupta, Angelina Konnova, Mathias Smet, Matilda Berkell, Alessia Savoldi, Matteo Morra, Vincent Van averbeke, Fien H.R. De Winter, Denise Peserico, Elisa Danese, An Hotterbeekx, Elda Righi, mAb ORCHESTRA working group, Pasquale De Nardo, Evelina Tacconelli, Surbhi Malhotra-Kumar, Samir Kumar-Singh

Publikováno v: The Journal of Clinical Investigation, Vol 133, Iss 6 (2023)

Background The role of host immunity in emergence of evasive SARS-CoV-2 Spike mutations under therapeutic monoclonal antibody (mAb) pressure remains to be explored.Methods In a prospective, observational, monocentric ORCHESTRA cohort study, conducted

Externí odkaz: https://doaj.org/article/d56a05fdc7834e8aaca163e81efb040b