Výsledky vyhledávání - "HOST-CELL INVASION"

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Akademický článek

Protein Disulfide Isomerase and Extracellular Adherence Protein Cooperatively Potentiate Staphylococcal Invasion into Endothelial Cells

Autor: Marleen Leidecker, Anne Bertling, Muzaffar Hussain, Markus Bischoff, Johannes A. Eble, Anke C. Fender, Kerstin Jurk, Christine Rumpf, Mathias Herrmann, Beate E. Kehrel, Silke Niemann

Publikováno v: Microbiology Spectrum, Vol 11, Iss 3 (2023)

ABSTRACT Invasion of host cells is an important feature of Staphylococcus aureus. The main internalization pathway involves binding of the bacteria to host cells, e.g., endothelial cells, via a fibronectin (Fn) bridge between S. aureus Fn binding pro

Externí odkaz: https://doaj.org/article/73e69fcca14b4482af13cb2f5dceb691

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Akademický článek

Salmonella spp. quorum sensing: an overview from environmental persistence to host cell invasion

Autor: Amanova Sholpan, Alexandre Lamas, Alberto Cepeda, arlos Manuel Franco

Publikováno v: AIMS Microbiology, Vol 7, Iss 2, Pp 238-256 (2021)

Salmonella spp. is one of the main foodborne pathogens around the world. It has a cyclic lifestyle that combines host colonization with survival outside the host, implying that Salmonella has to adapt to different conditions rapidly in order to survi

Externí odkaz: https://doaj.org/article/e2e9388cd7f046d4a32c1442a57d2c76

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Akademický článek

The Lectin LecB Induces Patches with Basolateral Characteristics at the Apical Membrane to Promote Pseudomonas aeruginosa Host Cell Invasion

Autor: Roland Thuenauer, Katja Kühn, Yubing Guo, Fruzsina Kotsis, Maokai Xu, Anne Trefzer, Silke Altmann, Sarah Wehrum, Najmeh Heshmatpour, Brian Faust, Alessia Landi, Britta Diedrich, Jörn Dengjel, E. Wolfgang Kuehn, Anne Imberty, Winfried Römer

Publikováno v: mBio, Vol 13, Iss 3 (2022)

ABSTRACT The opportunistic bacterium Pseudomonas aeruginosa can infect mucosal tissues of the human body. To persist at the mucosal barrier, this highly adaptable pathogen has evolved many strategies, including invasion of host cells. Here, we show t

Externí odkaz: https://doaj.org/article/e135b4483a924f88ab0c8b3fcb3a5553

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Akademický článek

Functional Characterization of the Thrombospondin-Related Paralogous Proteins Rhoptry Discharge Factors 1 and 2 Unveils Phenotypic Plasticity in Toxoplasma gondii Rhoptry Exocytosis

Autor: Alessia Possenti, Manlio Di Cristina, Chiara Nicastro, Matteo Lunghi, Valeria Messina, Federica Piro, Lorenzo Tramontana, Simona Cherchi, Mario Falchi, Lucia Bertuccini, Furio Spano

Publikováno v: Frontiers in Microbiology, Vol 13 (2022)

To gain access to the intracellular cytoplasmic niche essential for their growth and replication, apicomplexan parasites such as Toxoplasma gondii rely on the timely secretion of two types of apical organelles named micronemes and rhoptries. Rhoptry

Externí odkaz: https://doaj.org/article/02bbb6fb6dc545be85a4f0c5f5693032

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Akademický článek

The Kinetoplastid-Specific Protein TcCAL1 Plays Different Roles During In Vitro Differentiation and Host-Cell Invasion in Trypanosoma cruzi

Autor: Jessica Rodríguez-Durán, Juan Pablo Gallardo, Catalina Dirney Alba Soto, Karina Andrea Gómez, Mariana Potenza

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

In the pathogen Typanosoma cruzi, the calcium ion (Ca2+) regulates key processes for parasite survival. However, the mechanisms decoding Ca2+ signals are not fully identified or understood. Here, we investigate the role of a hypothetical Ca2+-binding

Externí odkaz: https://doaj.org/article/2f7097c628e8443fa260bb05e8bc9042

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Akademický článek

Unrevealing the Mystery of Latent Leishmaniasis: What Cells Can Host Leishmania?

Autor: Andrea Valigurová, Iva Kolářová

Publikováno v: Pathogens, Vol 12, Iss 2, p 246 (2023)

Leishmania spp. (Kinetoplastida) are unicellular parasites causing leishmaniases, neglected tropical diseases of medical and veterinary importance. In the vertebrate host, Leishmania parasites multiply intracellularly in professional phagocytes, such

Externí odkaz: https://doaj.org/article/ed3df138268b4f138dd4e413c2b876e5

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Akademický článek

Shedding of Trypanosoma cruzi Surface Molecules That Regulate Host Cell Invasion Involves Phospholipase C and Increases Upon Sterol Depletion

Autor: Leonardo Loch, Thiago Souza Onofre, João Paulo Ferreira Rodrigues, Nobuko Yoshida

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)

Metacyclic trypomastigote (MT) forms of Trypanosoma cruzi have been shown to release into medium gp82 and gp90, the stage-specific surface molecules that regulate host cell invasion, either in vesicles or in soluble form. Here, we found that during i

Externí odkaz: https://doaj.org/article/eace7958770b4932a0b1ff2867ac59ee

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Akademický článek

Depletion of Na+/H+ Exchanger Isoform 1 Increases the Host Cell Resistance to Trypanosoma cruzi Invasion

Autor: João Paulo Ferreira Rodrigues, Leonardo Loch, Thiago Souza Onofre, Nobuko Yoshida

Publikováno v: Pathogens, Vol 11, Iss 11, p 1294 (2022)

Na+/H+ exchanger isoform 1 (NHE1), a member of a large family of integral membrane proteins, plays a role in regulating the cortical actin cytoskeleton. Trypanosoma cruzi, the agent of Chagas disease, depends on F-actin rearrangement and lysosome mob

Externí odkaz: https://doaj.org/article/0e97184d75d1416fb5a404cae0f9d435

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