Identification of novel neutrophil very long chain plasmalogen molecular species and their myeloperoxidase mediated oxidation products in human sepsis

Autor: Kaushalya Amunugama, Matthew J. Jellinek, Megan P. Kilroy, Carolyn J. Albert, Valerio Rasi, Daniel F. Hoft, Michael G.S. Shashaty, Nuala J. Meyer, David A. Ford

Publikováno v: Redox Biology
Redox Biology, Vol 48, Iss, Pp 102208-(2021)

Plasmalogens are a class of phospholipids containing vinyl ether linked aliphatic groups at the sn-1 position. Plasmalogens are known to contain 16- and 18-carbon aliphatic groups at the sn-1 position. Here, we reveal that the human neutrophil plasme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991be0461f8ad91bb141668ad24ed6d9
https://pubmed.ncbi.nlm.nih.gov/34902676

Dissecting the low catalytic capability of flavin-dependent halogenases

Autor: Penchit Chitnumsub, Warangkhana Songsungthong, Chadaporn Kantiwiriyawanitch, Adrian J. Mulholland, Aritsara Jaruwat, Pimchai Chaiyen, Narin Lawan, Duangthip Trisrivirat, Surawit Visitsatthawong, Kridsadakorn Prakinee, Karl-Heinz van Pée, Pirom Chenprakhon, Aisaraphon Phintha

Publikováno v: Phintha, A, Prakinee, K, Jaruwat, A, Lawan, N, Visitsatthawong, S, Kantiwiriyawanitch, C, Songsungthong, W, Trisrivirat, D, Chenprakhon, P, Mulholland, A, van Pée, K-H, Chitnumsub, P & Chaiyen, P 2021, ' Dissecting the low catalytic capability of flavin-dependent halogenases ', Journal of Biological Chemistry, vol. 296, 100068, pp. 100068 . https://doi.org/10.1074/jbc.RA120.016004
The Journal of Biological Chemistry

Although flavin-dependent halogenases (FDHs) are attractive biocatalysts, their practical applications are limited because of their low catalytic efficiency. Here, we investigated the reaction mechanisms and structures of tryptophan 6-halogenase (Tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada40f468526b9483430aa5b3b4ae747
https://hdl.handle.net/1983/abdb69bf-dfab-4177-bda5-14b7a2899da6

Hyper-truncated Asn355- and Asn391-glycans modulate the activity of neutrophil granule myeloperoxidase

Autor: Rebeca Kawahara, Fabian Soltermann, Hannes Hinneburg, Siyun Chen, Robert J. Woods, Regis Dieckmann, Morten Thaysen-Andersen, Ian Loke, Vignesh Venkatakrishnan, Weston B. Struwe, Oliver C. Grant, Alison Rodger, Julian Ugonotti, Harry C. Tjondro, Johan Bylund, Benjamin L. Parker, Anna Karlsson-Bengtsson, Sayantani Chatterjee

Publikováno v: The Journal of Biological Chemistry

Myeloperoxidase (MPO) plays essential roles in neutrophil-mediated immunity via the generation of reactive oxidation products. Complex carbohydrates decorate MPO at discrete sites, but their functional relevance remains elusive. To this end, we have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb89deed8bac3a14bb7b67d39adbec0
https://pubmed.ncbi.nlm.nih.gov/33273015

gRASping the redox lever to modulate cancer cell fate signaling

Autor: Chuan Han Jonathan Foo, Shazib Pervaiz

Publikováno v: Redox Biology, Vol 25, Iss, Pp-(2019)
Redox Biology

RAS proteins are critical regulators of signaling networks controlling diverse cellular functions such as cell proliferation and survival and its mutation are among the most powerful oncogenic drivers in human cancers. Despite intense efforts, direct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11cd3c78529b5f4eae7369f41a3e411
http://www.sciencedirect.com/science/article/pii/S2213231718311558

Levels of inflammation and oxidative stress, and a role for taurine in dystropathology of the Golden Retriever Muscular Dystrophy dog model for Duchenne Muscular Dystrophy

Autor: Peter G. Arthur, Miranda D. Grounds, Amber E. Boyatzis, Jessica R. Terrill, Marisa N. Duong, Rufus Turner, Anthony J. Kettle, Caroline Le Guiner

Publikováno v: Redox Biology, Vol 9, Iss C, Pp 276-286 (2016)
Redox Biology

Duchenne Muscular Dystrophy (DMD) is a fatal skeletal muscle wasting disease presenting with excessive myofibre necrosis and increased inflammation and oxidative stress. In the mdx mouse model of DMD, homeostasis of the amino acid taurine is altered,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23acd2e8549bc1dba64a7f52e4413240