Zobrazeno 1 - 10
of 158
pro vyhledávání: '"HNSCC, Head and neck squamous cell carcinoma"'
Autor:
Karl F. B. Payne, Peter Brotherwood, Harini Suriyanarayanan, Jill M. Brooks, Nikolaos Batis, Andrew D. Beggs, Deena M. A. Gendoo, Hisham Mehanna, Paul Nankivell
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundAs circulating tumour DNA (ctDNA) liquid biopsy analysis is increasingly incorporated into modern oncological practice, establishing the impact of genomic intra-tumoural heterogeneity (ITH) upon data output is paramount. Despite advances in
Externí odkaz:
https://doaj.org/article/e05145d79eb243d7a8953e7b92d45ddb
Autor:
Frederic Jungbauer, Annette Affolter, Christoph Brochhausen, Anne Lammert, Sonja Ludwig, Kirsten Merx, Nicole Rotter, Lena Huber
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionCheckpoint inhibitors, such as PD1 inhibitors, represent an important pillar in the therapy of advanced malignancies of the head and neck region. The most relevant complications are immune-related adverse effects (irAEs), which represent
Externí odkaz:
https://doaj.org/article/a9671283f38448478180547515e7c6e1
Autor:
Qingyun Liao, Jing Yang, Zhaoyi Lu, Qingshan Jiang, Yongqian Gong, Lijun Liu, Hong Peng, Qin Wang, Xin Zhang, Zhifeng Liu
Publikováno v:
PeerJ, Vol 11, p e16493 (2023)
Background Currently, ferritin heavy chain (FTH1) has been increasingly found to play a crucial role in cancer as a core regulator of ferroptosis, while its role of non-ferroptosis in head and neck squamous cell carcinoma (HNSCC) is still unclear. Me
Externí odkaz:
https://doaj.org/article/753a1257fa8b4b5e8e79415bf24f469e
Autor:
Moritz Knebel, Sandrina Körner, Jan Philipp Kühn, Silke Wemmert, Lukas Brust, Sigrun Smola, Mathias Wagner, Rainer M. Bohle, Luc G. T. Morris, Abhinav Pandey, Bernhard Schick, Maximilian Linxweiler
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundDue to the expanding role of immune checkpoint inhibition in the treatment of head and neck squamous cell carcinoma, understanding immunological processes in the tumor microevironment (TME) has strong translational importance. Though analyt
Externí odkaz:
https://doaj.org/article/30b9a2010e504d77a57499bbbac3ac7c
Autor:
José A. Peña-Flores, Mercedes Bermúdez, Rosalío Ramos-Payán, Carlos E. Villegas-Mercado, Uriel Soto-Barreras, Daniela Muela-Campos, Alexis Álvarez-Ramírez, Brenda Pérez-Aguirre, Ana D. Larrinua-Pacheco, César López-Camarillo, Jorge A. López-Gutiérrez, Julio Garnica-Palazuelos, Marvin E. Estrada-Macías, Juan L. Cota-Quintero, Andrés A. Barraza-Gómez
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Head and neck squamous cell carcinoma (HNSCC) originates in the squamous cell lining the mucosal surfaces of the head and neck region, including the oral cavity, nasopharynx, tonsils, oropharynx, larynx, and hypopharynx. The heterogeneity, anatomical
Externí odkaz:
https://doaj.org/article/afcd7d9c71fe43f7bec1c6d23bfa0896
Autor:
Nathan M. Ryan, Felipe F. Lamenza, Puja Upadhaya, Hasan Pracha, Anna Springer, Michael Swingler, Arham Siddiqui, Steve Oghumu
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Head and neck squamous cell carcinomas (HNSCC) are one of the most diagnosed malignancies globally, with a 5-year survival rate of approximately 40% to 50%. Current therapies are limited to highly invasive surgery, aggressive radiation, and chemother
Externí odkaz:
https://doaj.org/article/a72504590b7b4317ac8bec1e2d7c6e0b
Publikováno v:
Frontiers in Oral Health, Vol 3 (2022)
The clinical response to cancer therapies involves the complex interplay between the systemic, tumoral, and stromal immune response as well as the direct impact of treatments on cancer cells. Each individual's immunological and cancer histories are d
Externí odkaz:
https://doaj.org/article/5aa08b36fb904caf8935237792bf6fa1
Autor:
Łukasz Boguszewicz
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
This review focuses on the molecular biology of head and neck squamous cell carcinomas and presents current and emerging biomarkers of the response of patients to induction chemotherapy. The usefulness of genes, proteins, and parameters from diagnost
Externí odkaz:
https://doaj.org/article/43bd81fe41b149b6bea4f683fcb6b5dc
Autor:
Erik Haehl, Alexander Rühle, Simon Spohn, Tanja Sprave, Eleni Gkika, Constantinos Zamboglou, Anca-Ligia Grosu, Nils H. Nicolay
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
ObjectivesThe number of elderly head-and-neck squamous cell carcinoma (HNSCC) patients is increasing, and clinical trials defining the standard of care either excluded or underrepresented elderly patients. This leaves physicians with a challenging an
Externí odkaz:
https://doaj.org/article/96c7d572d19446819f25989fca490b31
Autor:
Henning Lauterbach, Sarah Schmidt, Kia Katchar, Xiaoping Qing, Corinne Iacobucci, Andy Hwang, Katia Schlienger, Ursula Berka, Josipa Raguz, Sarah Ahmadi-Erber, Timo Schippers, Felix Stemeseder, Daniel D. Pinschewer, Igor Matushansky, Klaus K. Orlinger
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Engineered viral vectors represent a promising strategy to trigger antigen-specific antitumor T cell responses. Arenaviruses have been widely studied because of their ability to elicit potent and protective T cell responses. Here, we provide an overv
Externí odkaz:
https://doaj.org/article/83895df6536743b1a3a0d3687cec5f20