Zobrazeno 1 - 10
of 2 965
pro vyhledávání: '"HNPCC"'
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101461- (2024)
Colorectal cancer (CRC) is a complicated illness caused by a mix of hereditary and environmental factors. It is one of the most common malignancies worldwide, yet it is also one of the most curable if detected early. There are three types of molecula
Externí odkaz:
https://doaj.org/article/a594d66f3b9a476d986c1012cada4b9c
Autor:
Dennis Witt, Ulrike Faust, Gertrud Strobl‐Wildemann, Marc Sturm, Rebecca Buchert, Theresia Zuleger, Jakob Admard, Nicolas Casadei, Stephan Ossowski, Tobias B. Haack, Olaf Rieß, Christopher Schroeder
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 11, Iss 6, Pp n/a-n/a (2023)
Abstract Background Lynch syndrome is one of the most common cancer predisposition syndromes. It is caused by inherited changes in the mismatch repair pathway. With current diagnostic approaches, a causative genetic variant can be found in less than
Externí odkaz:
https://doaj.org/article/a2de4ff48ae340b18add3eba04f75192
Akademický článek
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Autor:
Philip R. Crain, Jamilyn M. Zepp, Sara Gille, Lindsay Jenkins, Tia L. Kauffman, Elizabeth Shuster, Katrina A.B. Goddard, Benjamin S. Wilfond, Jessica Ezzell Hunter
Publikováno v:
Hereditary Cancer in Clinical Practice, Vol 20, Iss 1, Pp 1-9 (2022)
Abstract Introduction Lynch syndrome (LS) is associated with an increased risk of colorectal (CRC) and endometrial (EC) cancers. Universal tumor screening (UTS) of all individuals diagnosed with CRC and EC is recommended to increase identification of
Externí odkaz:
https://doaj.org/article/46e06b365bfc42bda27622e8eefbfdd6
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionPatients with Lynch syndrome (LS) have an increased lifetime risk of pancreatic cancer (PC) and biliary tract cancer (BTC). These cancers have a notoriously pessimistic prognosis due to late diagnosis and limited therapeutic options. Ther
Externí odkaz:
https://doaj.org/article/399397f4983d48bbbad14418ad44bddf
Autor:
Adewale Adeoba Ayeni, Peter Waterland, Matthew Evans, Shika Singhal, Rajan Kumar Patel, Akinfemi Akingboye
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
It is a known fact that Lynch syndrome (LS) and Ulcerative colitis (UC) are individually associated with increased risk of colorectal cancer. While there is no conclusive evidence to demonstrate a cumulative risk when these two conditions coexist, av
Externí odkaz:
https://doaj.org/article/e3053ee437d34426ac8c179ea0d5ffd9
Publikováno v:
Journal of Pediatric Surgery Case Reports, Vol 86, Iss , Pp 102431- (2022)
Lynch syndrome is an autosomal dominant condition caused by a heterozygous variation in one of the DNA mismatch repair (MMR) genes that pre-disposes individuals to early onset colorectal cancers and other malignancies. Lynch syndrome is generally con
Externí odkaz:
https://doaj.org/article/9b54fb0a82ef4116a832064818e313e6
Publikováno v:
Hereditary Cancer in Clinical Practice, Vol 19, Iss 1, Pp 1-12 (2021)
Abstract Background Although extended colectomy (EC) was recommended for HNPCC patients, previous studies did not show significantly improved overall survival. Immunohistochemical (IHC) stain of mismatch repair (MMR) gene protein expression is now a
Externí odkaz:
https://doaj.org/article/f267d603107242619fb1f673d324e149
Publikováno v:
Clinical and Experimental Gastroenterology, Vol Volume 14, Pp 181-197 (2021)
Christina Therkildsen,1,2 Lars Henrik Jensen,3 Maria Rasmussen,2 Inge Bernstein4,5 1Department of Surgical Gastroenterology, Copenhagen University Hospital, Copenhagen, Denmark; 2The Danish HNPCC Register, Department of Clinical Research, Copenhagen
Externí odkaz:
https://doaj.org/article/98b906f060614e688f95c8762603f427
Autor:
Muhammad Usman Rashid, Humaira Naeemi, Noor Muhammad, Asif Loya, Jan Lubiński, Anna Jakubowska, Muhammed Aasim Yusuf
Publikováno v:
Hereditary Cancer in Clinical Practice, Vol 17, Iss 1, Pp 1-16 (2019)
Abstract Background Pathogenic germline variants in MLH1, MSH2 and MSH6 genes account for the majority of Lynch syndrome (LS). In this first report from Pakistan, we investigated the prevalence of pathogenic MLH1/MSH2/MSH6 variants in colorectal canc
Externí odkaz:
https://doaj.org/article/7a09e9c0c1cf4529b55b6fc3f54d68a9