Zobrazeno 1 - 10
of 10
pro vyhledávání: '"HMGB1, high mobility group box protein 1"'
Autor:
Wen-Xing Ding, Hartmut Jaeschke, David S Umbaugh, Olamide B. Adelusi, Giselle Sanchez-Guerrero, Nga T. Nguyen, Jephte Y. Akakpo, Anup Ramachandran
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)
Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at therapeutic doses but can cause severe liver injury and even liver failure after overdoses. The mouse model of APAP hepatotoxicity recapitulates closely the human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde30b76b24a28a9236a78a6ec2b0a30
https://pubmed.ncbi.nlm.nih.gov/35024303
https://pubmed.ncbi.nlm.nih.gov/35024303
Publikováno v:
International Immunopharmacology
SARS-CoV-2, as the causative agent of COVID-19, is an enveloped positives-sense single-stranded RNA virus that belongs to the Beta-CoVs sub-family. A sophisticated hyper-inflammatory reaction named cytokine storm is occurred in patients with severe/c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4706f42d886bb679ed2a6b85453a9c
https://pubmed.ncbi.nlm.nih.gov/34601331
https://pubmed.ncbi.nlm.nih.gov/34601331
Autor:
Azita H, Talasaz, Parham, Sadeghipour, Hessam, Kakavand, Maryam, Aghakouchakzadeh, Elaheh, Kordzadeh-Kermani, Benjamin W, Van Tassell, Azin, Gheymati, Hamid, Ariannejad, Seyed Hossein, Hosseini, Sepehr, Jamalkhani, Michelle, Sholzberg, Manuel, Monreal, David, Jimenez, Gregory, Piazza, Sahil A, Parikh, Ajay J, Kirtane, John W, Eikelboom, Jean M, Connors, Beverley J, Hunt, Stavros V, Konstantinides, Mary, Cushman, Jeffrey I, Weitz, Gregg W, Stone, Harlan M, Krumholz, Gregory Y H, Lip, Samuel Z, Goldhaber, Behnood, Bikdeli
Publikováno v:
Talasaz, A H, Sadeghipour, P, Kakavand, H, Aghakouchakzadeh, M, Kordzadeh-Kermani, E, Van Tassell, B W, Gheymati, A, Ariannejad, H, Hosseini, S H, Jamalkhani, S, Sholzberg, M, Monreal, M, Jimenez, D, Piazza, G, Parikh, S A, Kirtane, A J, Eikelboom, J W, Connors, J M, Hunt, B J, Konstantinides, S V, Cushman, M, Weitz, J I, Stone, G W, Krumholz, H M, Lip, G Y H, Goldhaber, S Z & Bikdeli, B 2021, ' Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19 : JACC State-of-the-Art Review ', Journal of the American College of Cardiology, vol. 77, no. 15, pp. 1903-1921 . https://doi.org/10.1016/j.jacc.2021.02.035
Journal of the American College of Cardiology
Journal of the American College of Cardiology
Endothelial injury and microvascular/macrovascular thrombosis are common pathophysiological features of coronavirus disease-2019 (COVID-19). However, the optimal thromboprophylactic regimens remain unknown across the spectrum of illness severity of C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9cfd53875c4beb17c4b2acdd6680cbaf
https://vbn.aau.dk/da/publications/4fc75eda-f137-462d-9d70-f4b8fb2a0e43
https://vbn.aau.dk/da/publications/4fc75eda-f137-462d-9d70-f4b8fb2a0e43
Autor:
Edson Jules, Mark Lipphardt, Tala Azar, Brian B. Ratliff, Wasan Abdulmahdi, Rameen Hashemiyoon, Devika Patel, May M. Rabadi
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 600-607 (2017)
Redox Biology
Redox Biology
During sepsis, the alarmin HMGB1 is released from tissues and promotes systemic inflammation that results in multi-organ damage, with the kidney particularly susceptible to injury. The severity of inflammation and pro-damage signaling mediated by HMG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819cf9ae63e7b350b8a0fb0ade3364d4
http://www.sciencedirect.com/science/article/pii/S2213231717304123
http://www.sciencedirect.com/science/article/pii/S2213231717304123
Autor:
Michelle Zur, Dympna M.P. Morrow, Mohammad Javdan, Mao Wang, Haichao Wang, Maria Entezari, Wenjun Wu, Jianhua Li, Lin L. Mantell, Douglas D. Thomas, Samir Gorasiya, Lokesh Sharma, Vivek Patel, Daniel J. Antoine, Ravikumar Sitapara, Huan Yang, Charles R. Ashby
Publikováno v:
Redox Biology
Redox Biology, Vol 2, Iss C, Pp 314-322 (2014)
Redox Biology, Vol 2, Iss C, Pp 314-322 (2014)
Prolonged exposure to hyperoxia results in acute lung injury (ALI), accompanied by a significant elevation in the levels of proinflammatory cytokines and leukocyte infiltration in the lungs. However, the mechanisms underlying hyperoxia-induced proinf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4518c04e697989885d7507938caa59
Akademický článek
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Autor:
Carneiro-Nascimento S; Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, United States., Levy D; Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, United States.
Publikováno v:
Neurobiology of pain (Cambridge, Mass.) [Neurobiol Pain] 2022 Apr 22; Vol. 11, pp. 100091. Date of Electronic Publication: 2022 Apr 22 (Print Publication: 2022).
Autor:
Habash NW; Gastroenterology Research Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN USA., Sehrawat TS; Gastroenterology Research Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN USA., Shah VH; Gastroenterology Research Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN USA., Cao S; Gastroenterology Research Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN USA.
Publikováno v:
JHEP reports : innovation in hepatology [JHEP Rep] 2022 Mar 10; Vol. 4 (5), pp. 100466. Date of Electronic Publication: 2022 Mar 10 (Print Publication: 2022).
Autor:
Jaeschke H; Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA., Adelusi OB; Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA., Akakpo JY; Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA., Nguyen NT; Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA., Sanchez-Guerrero G; Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA., Umbaugh DS; Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA., Ding WX; Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA., Ramachandran A; Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Publikováno v:
Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 Dec; Vol. 11 (12), pp. 3740-3755. Date of Electronic Publication: 2021 Sep 30.
Autor:
Entezari M; Department of Pharmaceutical Sciences, St. John׳s University, College of Pharmacy and Health Sciences, Queens, NY 11439, USA ; The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhasset, NY 11030, USA ; Department of Natural Science, LaGuardia Community College City University of New York, Queens, NY 11101, USA., Javdan M; Department of Pharmaceutical Sciences, St. John׳s University, College of Pharmacy and Health Sciences, Queens, NY 11439, USA ; The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhasset, NY 11030, USA ; Department of Natural Science, LaGuardia Community College City University of New York, Queens, NY 11101, USA., Antoine DJ; Medical Research Council Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, United Kingdom., Morrow DM; Department of Pharmaceutical Sciences, St. John׳s University, College of Pharmacy and Health Sciences, Queens, NY 11439, USA ; The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhasset, NY 11030, USA., Sitapara RA; Department of Pharmaceutical Sciences, St. John׳s University, College of Pharmacy and Health Sciences, Queens, NY 11439, USA., Patel V; Department of Pharmaceutical Sciences, St. John׳s University, College of Pharmacy and Health Sciences, Queens, NY 11439, USA., Wang M; Department of Pharmaceutical Sciences, St. John׳s University, College of Pharmacy and Health Sciences, Queens, NY 11439, USA., Sharma L; Department of Pharmaceutical Sciences, St. John׳s University, College of Pharmacy and Health Sciences, Queens, NY 11439, USA., Gorasiya S; Department of Pharmaceutical Sciences, St. John׳s University, College of Pharmacy and Health Sciences, Queens, NY 11439, USA., Zur M; Department of Pharmaceutical Sciences, St. John׳s University, College of Pharmacy and Health Sciences, Queens, NY 11439, USA., Wu W; Department of Pharmaceutical Sciences, St. John׳s University, College of Pharmacy and Health Sciences, Queens, NY 11439, USA., Li J; Department of Pharmaceutical Sciences, St. John׳s University, College of Pharmacy and Health Sciences, Queens, NY 11439, USA., Yang H; The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhasset, NY 11030, USA., Ashby CR; Department of Pharmaceutical Sciences, St. John׳s University, College of Pharmacy and Health Sciences, Queens, NY 11439, USA., Thomas D; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL 60607, USA., Wang H; The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhasset, NY 11030, USA., Mantell LL; Department of Pharmaceutical Sciences, St. John׳s University, College of Pharmacy and Health Sciences, Queens, NY 11439, USA ; The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhasset, NY 11030, USA.
Publikováno v:
Redox biology [Redox Biol] 2014 Jan 20; Vol. 2, pp. 314-22. Date of Electronic Publication: 2014 Jan 20 (Print Publication: 2014).