Zobrazeno 1 - 10 of 271 pro vyhledávání: '"HM Henk Buck"'
1
Phosphate-Methylated Oligonucleotides Past, Present and Future
Autor: HM Henk Buck
Publikováno v: Journal of Biophysical Chemistry. 11:27-42
At the moment, we see a great interest for application of Anti Sense Oligonucleotides (ASOs) in order to regulate the expression of genes related to certain diseases. These nucleotides obtained a number of fascinating properties by means of chemical
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5ed7b323a28917e165e34885a637044
https://doi.org/10.4236/jbpc.2020.113003
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2
DNA-Like Duplex Structures Derived from Chemistry Based on 2’-Deoxy-Cytidine: A New Model for Base-Specific Inhibition of G and C on DNA and RNA Level
Autor: HM Henk Buck
Publikováno v: Journal of Biophysical Chemistry. :23-40
The new epigenetic elements 5-hydroxymethyl-dC, 5-formyl-dC, and 5-car- boxy-dC may be considered as intermediates of an active demethylation process. A comprehensive mechanistic model is given for the C-C bond cleavage focused on the chemistry withi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbb5a9b5c25bb464b6906179608253e2
https://doi.org/10.4236/jbpc.2018.93003
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3
Modified RNA with a Phosphate-Methylated Backbone. A Serious Omission in Our (Retracted) Study at HIV-1 RNA Loops and Integrated DNA. Specific Properties of the (Modified) RNA and DNA Dimers
Autor: HM Henk Buck
Publikováno v: Journal of Biophysical Chemistry. :30-41
After the recent publication in the Journal of Biophysical Chemistry entitled “Retracted HIV Study Provides New Information about the Status of the in Vitro Inhibition of DNA Replication by Back-bone Methylation”, it is of importance to review th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f5a84c679fb9511b84cb7dd69fd4cc6
https://doi.org/10.4236/jbpc.2016.71003
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4
A conformational B-Z DNA study monitored with phosphatemethylated DNA as a model for epigenetic dynamics focused on 5-(hydroxy)methylcytosine
Autor: HM Henk Buck
Publikováno v: Journal of Biophysical Chemistry. :37-46
This study was directed on the B- into Z-DNA isomerization with alternating CG sequences monitored with artificial DNA model-systems based on methylation of the phosphate backbone. The chemical concept for this transition wherein shielding of the oxy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5b754f6bf1d06f210a3e40f9235347b
https://doi.org/10.4236/jbpc.2013.42005
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6
Dna Systems for B-Z Transition and Their Significance as Epigenetic Model: The Fundamental Role of the Methyl Group
Autor: HM Henk Buck
Publikováno v: Nucleosides, Nucleotides and Nucleic Acids. 30:918-944
Epigenetic systems involved in the dynamics of gene expression, which are fundamental to cell determination and function without alteration in DNA sequences, are based on methylation of the N-terminal tails of lysine residues and DNA methylation. We
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f175eb6720881490551dd9d6cc9fba8
https://doi.org/10.1080/15257770.2011.620580
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7
A model investigation of ab initio geometries for identity and nonidentity substitution with three-center four- and three-electron transition states
Autor: HM Henk Buck
Publikováno v: International Journal of Quantum Chemistry. 111:2242-2250
With the van't Hoff model derived from the dynamics of a regular tetrahedron in which the interstitial carbon changes its position from tetrahedral into a trigonal (bi)pyramidal configuration, the introduction of dimensionless ratio numbers (R) can s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5322de98e5d6bc4df5b5eafe0b76d7c9
https://doi.org/10.1002/qua.22529
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8
Molecular model studies based on ab initio calculations of nucleophilic and electrophilic addition-substitution reactions focused on carbon-halogen compounds
Autor: HM Henk Buck
Publikováno v: International Journal of Quantum Chemistry. 111:4472-4482
We describe with molecular model studies based on the intrinsic parameters of van't Hoff's regular tetrahedron nucleophilic and electrophilic addition-substitution reactions via a selected reaction coordinate for the displacement of carbon. Geometrie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6433533699667b835221b3c870bf2794
https://doi.org/10.1002/qua.22937
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9
Solvent dependence of the rotamer population around the interglycosidic C(5)C(6) bond of (1→6)-β-linked digalactopyranosides
Autor: de Nk Koen Vries, HM Henk Buck
Publikováno v: Recueil des Travaux Chimiques des Pays-Bas, 106(8), 453-460. Royal Netherlands Chemical Society
A 300-MHz 1H NMR study of the rotamer population around the interglycosidic C(5)C(6) bond of methyl 2,3,4-tri-O-methyl-6-O-(2,3,4,6-tetra-O-acetyl-ß-D-galactopyranosyl)-ß- (1) and --D-galactopyranoside (2) is reported. The existence of the (1¿6)-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54a28cd44188fe5e9546ce92e18ddbe
https://doi.org/10.1002/recl.19871060804
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