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Detection of Nonsynonymous Single Variants in Human HLA-DRB1 Exon 2 Associated with Renal Transplant Rejection

Autor: Ashour, Mohamed M. Hassan, Mohamed A. Hussain, Sababil S. Ali, Mohammed A. Mahdi, Nouh Saad Mohamed, Hanadi AbdElbagi, Osama Mohamed, Asmaa E. Sherif, Wadah Osman, Sabrin R. M. Ibrahim, Kholoud F. Ghazawi, Samar F. Miski, Gamal A. Mohamed, Ahmed

Publikováno v: Medicina; Volume 59; Issue 6; Pages: 1116

Background: HLA-DRB1 is the most polymorphic gene in the human leukocyte antigen (HLA) class II, and exon 2 is critical because it encodes antigen-binding sites. This study aimed to detect functional or marker genetic variants of HLA-DRB1 exon 2 in r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::5d4870f7507f1128cd0977507a2c6ad2

Genome-wide association study of circulating interleukin 6 levels identifies novel loci

Autor: Martina Müller-Nurasyid, Jerome I. Rotter, David M. Evans, John P. Kemp, Emelia J. Benjamin, Graciela E. Delgado, Vilmundur Gudnason, Ann Hammarstedt, Panos Deloukas, Aroon D. Hingorani, Riccardo E. Marioni, David Stacey, Jenny van Dongen, Eric Boerwinkle, Joachim Heinrich, Yongmei Liu, S. Goya Wannamethee, Delilah Zabaneh, Braxton D. Mitchell, Marie Standl, Jackie F. Price, Maria G. Stathopoulou, Yoav Ben-Shlomo, Joris Deelen, Eero Kajantie, Mohammadreza Abdollahi, Christie M. Ballantyne, Johan G. Eriksson, Ilkka Seppälä, Elnaz Naderi, Barbara J. Jefferis, Richard W Morris, Nicholas J. Timpson, George Dedoussis, Sirpa Jalkanen, Mika Kivimäki, Perminder S. Sachdev, Diana van Heemst, Melanie Waldenberger, Gaurav Singhal, Elisabeth Thiering, Olli T. Raitakari, Anders Hamsten, Zoltán Kutalik, L. Bain, Eco J. C. de Geus, Tarunveer S. Ahluwalia, Yuri Milaneschi, Hubert Scharnagl, Juan P. Casas, Georg Homuth, Claes Ohlsson, Abbas Dehghan, Nicola J. Armstrong, Behrooz Z. Alizadeh, Terho Lehtimäki, Steve E. Humphries, Naveed Sattar, Bram P. Prins, Peter Rossing, Sophie Visvikis-Siest, Joana A. Revez, Ilja M. Nolte, Stella Trompet, Harold Snieder, Marian Beekman, Diana Marek, Beate St Pourcain, Thorkild I. A. Sørensen, Silvia Naitza, Karen A. Mather, Uwe Völker, Eline Slagboom, Tina Shah, Magdalene C. Jawahar, Jens Baumert, Alexander Teumer, Dorret I. Boomsma, Marcus E. Kleber, Peter Vollenweider, Wolfgang Koenig, Brenda W.J.H. Penninx, Kenneth Rice, Ian J. Deary, Pedro Marques-Vidal, Donna K. Arnett, Eleonora Porcu, Jouke-Jan Hottenga, Maria Sabater-Lleal, Bruce M. Psaty, Matthias Nauck, Dan Mellström, Joel Eriksson, Bernhard T. Baune, Debbie A Lawlor, Catherine Toben, Peter H. Whincup, Toshiko Tanaka, Stavroula Kanoni, Katri Räikkönen, Gonneke Willemsen, Bengt Sennblad, Julian N. Trollor, Yalda Jamshidi, Sarah E. Harris, Jari Lahti, Joshua C. Bis, Peter Durda, Yen Pei C. Chang, Jorgen Engmann, Tom R. Gaunt, Stella Aslibekyan, Anbupalam Thalamuthu, Mary F. Feitosa, Angela Silveira, Tine Jess, Stela McLachlan, J. Wouter Jukema, Chen Lu, Simon P. Mooijaart, Tim D. Spector, Harald Grallert, Winfried März, Alexandros M. Petrelis, Manuel A. R. Ferreira, Meena Kumari

Publikováno v: Human molecular genetics, 30(5), 393-409. Oxford University Press
Human Molecular Genetics, 30(5), 393-409. OXFORD UNIV PRESS
Human Molecular Genetics
Ahluwalia, T S, De Geus, E, Milaneschi, Y, Hottenga, J-J, Van Dongen, J, Willemsen, G, Boomsma, D I, Alizadeh, B Z & CHARGE Inflammation Working Group 2021, ' Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci ', Human molecular genetics, vol. 30, no. 5, pp. 393-409 . https://doi.org/10.1093/hmg/ddab023
Hum Mol Genet
Human Molecular Genetics, 30(5), 393-409. Oxford University Press
Human molecular genetics, vol. 30, no. 5, pp. 393-409
CHARGE Inflammation working group 2021, ' Genome-wide association study of circulating interleukin 6 levels identifies novel loci ', Human Molecular Genetics, vol. 30, no. 5, pp. 393-409 . https://doi.org/10.1093/hmg/ddab023
Human Molecular Genetics, Oxford University Press (OUP), 2021, ⟨10.1093/hmg/ddab023⟩
Hum. Mol. Genet. 30, 393-409 (2021)
Ahluwalia, T S, Prins, B P, Abdollahi, M, Armstrong, N J, Aslibekyan, S, Bain, L, Jefferis, B, Baumert, J, Beekman, M, Ben-shlomo, Y, Bis, J C, Mitchell, B D, De Geus, E, Delgado, G E, Marek, D, Eriksson, J, Kajantie, E, Kanoni, S, Kemp, J P, Lu, C, Marioni, R E, Mclachlan, S, Milaneschi, Y, Nolte, I M, Petrelis, A M, Porcu, E, Sabater-lleal, M, Naderi, E, Seppälä, I, Shah, T, Singhal, G, Standl, M, Teumer, A, Thalamuthu, A, Thiering, E, Trompet, S, Ballantyne, C M, Benjamin, E J, Casas, J P, Toben, C, Dedoussis, G, Deelen, J, Durda, P, Engmann, J, Feitosa, M F, Grallert, H, Hammarstedt, A, Harris, S E, Homuth, G, Hottenga, J, Jalkanen, S, Jamshidi, Y, Jawahar, M C, Jess, T, Kivimaki, M, Kleber, M E, Lahti, J, Liu, Y, Marques-vidal, P, Mellström, D, Mooijaart, S P, Müller-nurasyid, M, Penninx, B, Revez, J A, Rossing, P, Räikkönen, K, Sattar, N, Scharnagl, H, Sennblad, B, Silveira, A, Pourcain, B S, Timpson, N J, Trollor, J, Van Dongen, J, Van Heemst, D, Visvikis-siest, S, Vollenweider, P, Völker, U, Waldenberger, M, Willemsen, G, Zabaneh, D, Morris, R W, Arnett, D K, Baune, B T, Boomsma, D I, Chang, Y C, Deary, I J, Deloukas, P, Eriksson, J G, Evans, D M, Ferreira, M A, Gaunt, T, Gudnason, V, Hamsten, A, Heinrich, J, Hingorani, A, Humphries, S E, Jukema, J W, Koeing, W, Kumari, M, Kutalik, Z, Lawlor, D A, Lehtimäki, T, März, W, Mather, K, Naitza, S, Nauck, M, Ohlsson, C, Price, J F, Raitakari, O, Rice, K, Sachdev, P S, Slagboom, E, Sørensen, T I A, Spector, T, Stacey, D, Stathopoulou, M G, Tanaka, T, Wannamethee, S G, Whincup, P, Rotter, J I, Dehghan, A, Boerwinkle, E, Psaty, B M, Snieder, H & Alizadeh, B Z 2021, ' Genome-wide association study of circulating Interleukin 6 levels identifies novel loci ', Human Molecular Genetics . https://doi.org/10.1093/hmg/ddab023
European Journal of Human Genetics, 28(SUPPL 1), 307-308. Nature Publishing Group
Ahluwalia, T S, Prins, B P, Abdollahi, M, Armstrong, N J, Aslibekyan, S, Bain, L, Jefferis, B, Baumert, J, Beekman, M, Ben-Shlomo, Y, Bis, J C, Mitchell, B D, de Geus, E, Delgado, G E, Marek, D, Eriksson, J, Kajantie, E, Kanoni, S, Kemp, J P, Lu, C, Marioni, R E, McLachlan, S, Milaneschi, Y, Nolte, I M, Petrelis, A M, Porcu, E, Sabater-Lleal, M, Naderi, E, Seppälä, I, Shah, T, Singhal, G, Standl, M, Teumer, A, Thalamuthu, A, Thiering, E, Trompet, S, Ballantyne, C M, Benjamin, E J, Casas, J P, Toben, C, Dedoussis, G, Deelen, J, Durda, P, Engmann, J, Feitosa, M F, Grallert, H, Hammarstedt, A, Jess, T, Rossing, P, Sørensen, T I A & CHARGE Inflammation Working Group 2021, ' Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci ', Human Molecular Genetics, vol. 30, no. 5, pp. 393–409 . https://doi.org/10.1093/hmg/ddab023

Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease patho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175e56e119fa2ad648eb40764e8c6ee2
https://doi.org/10.1093/hmg/ddab023

Association analysis of human leukocyte antigen class II (DRB1) alleles with leprosy in individuals from São Luís, state of Maranhão, Brazil

Autor: Rita da Graça Carvalhal Frazão Corrêa, Dorlene Maria Cardoso de Aquino, Arlene de Jesus Mendes Caldas, Humberto de Oliveira Serra, Fábio França Silva, Maxwellem de Jesus Costa Ferreira, Elton Jonh Freitas Santos, Emygdia Rosa Rêgo Barros Pires Leal Mesquita

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 107, Iss suppl 1, Pp 150-155 (2012)

Epidemiological studies have demonstrated that the variability of the clinical response to infection caused by Mycobacterium leprae is associated with host genetic factors. The present study investigated the frequency of human leukocyte antigen (HLA)

Externí odkaz: https://doaj.org/article/490739da36d247a0b1cd5876fa1eb5a8