Výsledky vyhledávání - "HLA Antigens/immunology"

Akademický článek

Early Antibody-Mediated Kidney Transplant Rejection: A Successful Case Without Donor-Specific Anti-HLA Antibodies

Autor: Rita M. Silva, Rita Leal, Maria G. Marques, Luís Rodrigues, Lídia Santos, Catarina Romãozinho, Arnaldo Figueiredo, Rui Alves

Publikováno v: Revista Portuguesa de Nefrologia e Hipertensão, Vol 37, Iss 2, Pp 89-92 (2023)

The diagnosis of antibody-mediated rejection has become more common and represents a major cause of kidney graft loss. The ideal treatment remains unknown, with little evidence supporting the use of a specific therapy. The definition of antibody-med

Externí odkaz: https://doaj.org/article/5c92b032b4a74586b3d779e94aa658ca

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Akademický článek

Successful Deceased Donor Kidney Transplantation in a Highly Sensitized Patient after Reclassification of Unacceptable Antigens Based on HLA Epitope Analysis

Autor: Daniela Alfere, Sandra Tafulo, Isabel Tavares, Ana Teresa Nunes, Ana Rocha, Manuela Bustorff, Susana Sampaio

Publikováno v: Revista Portuguesa de Nefrologia e Hipertensão, Vol 36, Iss 4, Pp 254-259 (2022)

For patients with end stage renal disease, kidney transplant offers significant survival and quality-of-life advantages compared with dialysis. But for patients seeking transplant who are highly sensitized, waiting times have traditionally been long

Externí odkaz: https://doaj.org/article/76d703d24f6b4e4597e61243e82518f3

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Akademický článek

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Outcomes of Human Leukocyte Antigen–Matched Allogeneic Cultivated Limbal Epithelial Transplantation in Aniridia-Associated Keratopathy—A Single-Center Retrospective Analysis

Autor: Alejandra Consejo, Neil Lagali, Sorcha Ní Dhubhghaill, Marie-José Tassignon, Carina Koppen, Joséphine Behaegel

Publikováno v: Cornea
Zaguán. Repositorio Digital de la Universidad de Zaragoza
Universitat Politècnica de Catalunya (UPC)

Purpose: To assess the efficacy and safety of human leukocyte antigen-matched allogeneic cultivated limbal epithelial stem cell grafts in the treatment of aniridia-associated keratopathy (AAK). Methods: Six eyes of 6 patients with severe AAK received

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc742454561094838eb2ee686e2ca37
https://doi.org/10.1097/ico.0000000000002729

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Peripheral Donor-specific Antibodies Are Associated With Histology and Cellular Subtypes in Protocol Liver Biopsies of Pediatric Recipients

Autor: Anne-Laure Rougemont, Vladimir L. Cousin, Laura Rubbia-Brandt, Jean Villard, Valérie A. McLin, Sylvie Ferrari-Lacraz, Barbara E. Wildhaber

Publikováno v: Transplantation, Vol. 104, No 8 (2020) pp. 1633-1643

Background The cellular infiltrate in protocol liver biopsies (PB) following pediatric liver transplantation remains mostly uncharacterized, yet there is increasing concern about the role of inflammation and fibrosis in long-term liver allografts. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64fe05d2f328c064d65c5dd4bbf4cb67
https://doi.org/10.1097/tp.0000000000003099

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T cell reconstitution after lymphocyte depletion features a different pattern of inhibitory receptor expression in ABO- versus HLA-incompatible kidney transplant recipients

Autor: A. Del Bello, Nassim Kamar, E Treiner

Publikováno v: Clinical and Experimental Immunology
Clinical and Experimental Immunology, Wiley, 2020, 200 (1), pp.89-104. ⟨10.1111/cei.13412⟩
Clin Exp Immunol

Summary Chronic antigen stimulation can lead to immune exhaustion (a state of T cell dysfunction). Several phenotypical signatures of T cell exhaustion have been described in various pathological situations, characterized by aberrant expression of mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224fd1281567a921d5b700e491fdcbe5
https://doi.org/10.1111/cei.13412

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Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link

Autor: Huyen Nguyen, Christian Wandell Thorball, Jacques Fellay, Jürg Böni, Sabine Yerly, Matthieu Perreau, Hans H Hirsch, Katharina Kusejko, Maria Christine Thurnheer, Manuel Battegay, Matthias Cavassini, Christian R Kahlert, Enos Bernasconi, Huldrych F Günthard, Roger D Kouyos, The Swiss HIV Cohort Study

Publikováno v: eLife
eLife, Vol. 10 (2021)
eLife, Vol 10 (2021)
Nguyen, Huyen; Thorball, Christian Wandell; Fellay, Jacques; Böni, Jürg; Yerly, Sabine; Perreau, Matthieu; Hirsch, Hans H; Kusejko, Katharina; Thurnheer, Maria Christine; Battegay, Manuel; Cavassini, Matthias; Kahlert, Christian R; Bernasconi, Enos; Günthard, Huldrych F; Kouyos, Roger D (2021). Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link. eLife, 10 eLife Sciences Publications 10.7554/eLife.67388
eLife, vol. 10

Background: Considering the remaining threat of drug-resistantmutations (DRMs) to antiretroviral treatment (ART) efficacy, we investigated how the selective pressure of human leukocyte antigen (HLA)-restricted cytotoxic T lymphocytes drives certain D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::42c8b537e13c9bb9fe47fcc7d8488c62
https://pubmed.ncbi.nlm.nih.gov/34061023

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Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia

Publikováno v: Immunity
Immunity, 2021, 54 (7), pp.1578-1593.e5. ⟨10.1016/j.immuni.2021.05.002⟩

Immune profiling of COVID-19 patients has identified numerous alterations in both innate and adaptive immunity. However, whether those changes are specific to SARS-CoV-2 or driven by a general inflammatory response shared across severely ill pneumoni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a70271704dd1c2b9bc69005e3664513
https://doi.org/10.1016/j.immuni.2021.05.002

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The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses

Publikováno v: Immunity
Immunity, 54(1), 132-150.e9. Cell Press
Immunity, 54(1), 132-150.e9. CELL PRESS

HLA class I (HLA-I) glycoproteins drive immune responses by presenting antigens to cognate CD8+ T cells. This process is often hijacked by tumors and pathogens for immune evasion. Because options for restoring HLA-I antigen presentation are limited,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc52593816d0dbe9f26a66bfd1bf047
https://europepmc.org/articles/PMC8722104/

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HLA Heterozygote Advantage against HIV-1 Is Driven by Quantitative and Qualitative Differences in HLA Allele-Specific Peptide Presentation

Autor: Mary Carrington, Tobias L. Lenz, Federica Pierini, Jacques Fellay, Paul J. McLaren, Jatin Arora

Publikováno v: Molecular biology and evolution, vol. 37, no. 3, pp. 639-650
Molecular Biology and Evolution

Pathogen-mediated balancing selection is regarded as a key driver of host immunogenetic diversity. A hallmark for balancing selection in humans is the heterozygote advantage at genes of the human leukocyte antigen (HLA), resulting in improved HIV-1 c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996687938bd13cc63fdb99d363b53a5f
https://serval.unil.ch/resource/serval:BIB_4A4E20C0A676.P001/REF.pdf

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