Zobrazeno 1 - 10 of 72 pro vyhledávání: '"HJ Kempen"'
1
Akademický článek
Evaluation of the use of serum lathosterol concentration to assess whole-body cholesterol synthesis in rabbits.
Autor: GW Meijer, JG Van der Palen, H De Vries, HJ Kempen, HA Van der Voort, LF Van Zutphen, AC Beynen
Publikováno v: Journal of Lipid Research, Vol 33, Iss 2, Pp 281-286 (1992)
Serum lathosterol concentration in rabbits was assessed as a possible indicator of whole-body cholesterol synthesis. In random-bred New Zealand White (NZW) rabbits fed a control diet or a diet containing either cholesterol, simvastatin, or cholestyra
Externí odkaz: https://doaj.org/article/640f62e2d4554bf99c441bd4340c8a42
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2
Akademický článek
Partial characterization of low density lipoprotein preparations isolated from fresh and frozen plasma after radiolabeling by seven different methods.
Autor: DE Atsma, HJ Kempen, W Nieuwenhuizen, FM van 't Hooft, EK Pauwels
Publikováno v: Journal of Lipid Research, Vol 32, Iss 1, Pp 173-181 (1991)
Four 99mTc and three 123I labeling methods were evaluated for their suitability to label low density lipoproteins (LDL) for the purpose of scintigraphic biodistribution studies. For 99mTc these methods were: direct incorporation in LDL of 99mTcO4- us
Externí odkaz: https://doaj.org/article/388d58970679483bb394fd00777324fd
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4
Akademický článek
Persistent changes in lipoprotein lipids after a single infusion of ascending doses of MDCO-216 (apoA-IMilano/POPC) in healthy volunteers and stable coronary artery disease patients.
Autor: Kempen HJ; The Medicines Company (Schweiz) GmbH, Zürich, Switzerland. Electronic address: herman.kempen@gmail.com., Gomaraschi M; Center E. Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Italy. Electronic address: monica.gomaraschi@unimi.it., Simonelli S; Center E. Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Italy., Calabresi L; Center E. Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Italy., Moerland M; Centre for Human Drug Research, Leiden, The Netherlands., Otvos J; LipoScience, Laboratory Corporation of America(®) Holdings, Raleigh, NC, USA., Jeyarajah E; LipoScience, Laboratory Corporation of America(®) Holdings, Raleigh, NC, USA., Kallend D; The Medicines Company (Schweiz) GmbH, Zürich, Switzerland., Wijngaard PLJ; The Medicines Company (Schweiz) GmbH, Zürich, Switzerland.
Publikováno v: Atherosclerosis [Atherosclerosis] 2016 Dec; Vol. 255, pp. 17-24. Date of Electronic Publication: 2016 Oct 24.
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5
Akademický článek
High-Density Lipoprotein Subfractions and Cholesterol Efflux Capacities After Infusion of MDCO-216 (Apolipoprotein A-IMilano/Palmitoyl-Oleoyl-Phosphatidylcholine) in Healthy Volunteers and Stable Coronary Artery Disease Patients.
Autor: Kempen HJ; From The Medicines Company (Schweiz) GmbH, Zürich, Switzerland (H.J.K., D.G.K., P.L.J.W.); Lipid Metabolism Laboratory, Tufts University, Boston, MA (B.F.A.); Center of Human Drug Research, Leiden, The Netherlands (M.M.); Liposcience, Laboratory Corporation of America Holdings, Raleigh, NC (E.J., J.O.); and The Medicines Company Inc, Parsippany, NJ (S.E.B.). herman.kempen@themedco.com., Asztalos BF; From The Medicines Company (Schweiz) GmbH, Zürich, Switzerland (H.J.K., D.G.K., P.L.J.W.); Lipid Metabolism Laboratory, Tufts University, Boston, MA (B.F.A.); Center of Human Drug Research, Leiden, The Netherlands (M.M.); Liposcience, Laboratory Corporation of America Holdings, Raleigh, NC (E.J., J.O.); and The Medicines Company Inc, Parsippany, NJ (S.E.B.)., Moerland M; From The Medicines Company (Schweiz) GmbH, Zürich, Switzerland (H.J.K., D.G.K., P.L.J.W.); Lipid Metabolism Laboratory, Tufts University, Boston, MA (B.F.A.); Center of Human Drug Research, Leiden, The Netherlands (M.M.); Liposcience, Laboratory Corporation of America Holdings, Raleigh, NC (E.J., J.O.); and The Medicines Company Inc, Parsippany, NJ (S.E.B.)., Jeyarajah E; From The Medicines Company (Schweiz) GmbH, Zürich, Switzerland (H.J.K., D.G.K., P.L.J.W.); Lipid Metabolism Laboratory, Tufts University, Boston, MA (B.F.A.); Center of Human Drug Research, Leiden, The Netherlands (M.M.); Liposcience, Laboratory Corporation of America Holdings, Raleigh, NC (E.J., J.O.); and The Medicines Company Inc, Parsippany, NJ (S.E.B.)., Otvos J; From The Medicines Company (Schweiz) GmbH, Zürich, Switzerland (H.J.K., D.G.K., P.L.J.W.); Lipid Metabolism Laboratory, Tufts University, Boston, MA (B.F.A.); Center of Human Drug Research, Leiden, The Netherlands (M.M.); Liposcience, Laboratory Corporation of America Holdings, Raleigh, NC (E.J., J.O.); and The Medicines Company Inc, Parsippany, NJ (S.E.B.)., Kallend DG; From The Medicines Company (Schweiz) GmbH, Zürich, Switzerland (H.J.K., D.G.K., P.L.J.W.); Lipid Metabolism Laboratory, Tufts University, Boston, MA (B.F.A.); Center of Human Drug Research, Leiden, The Netherlands (M.M.); Liposcience, Laboratory Corporation of America Holdings, Raleigh, NC (E.J., J.O.); and The Medicines Company Inc, Parsippany, NJ (S.E.B.)., Bellibas SE; From The Medicines Company (Schweiz) GmbH, Zürich, Switzerland (H.J.K., D.G.K., P.L.J.W.); Lipid Metabolism Laboratory, Tufts University, Boston, MA (B.F.A.); Center of Human Drug Research, Leiden, The Netherlands (M.M.); Liposcience, Laboratory Corporation of America Holdings, Raleigh, NC (E.J., J.O.); and The Medicines Company Inc, Parsippany, NJ (S.E.B.)., Wijngaard PL; From The Medicines Company (Schweiz) GmbH, Zürich, Switzerland (H.J.K., D.G.K., P.L.J.W.); Lipid Metabolism Laboratory, Tufts University, Boston, MA (B.F.A.); Center of Human Drug Research, Leiden, The Netherlands (M.M.); Liposcience, Laboratory Corporation of America Holdings, Raleigh, NC (E.J., J.O.); and The Medicines Company Inc, Parsippany, NJ (S.E.B.).
Publikováno v: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2016 Apr; Vol. 36 (4), pp. 736-42. Date of Electronic Publication: 2016 Feb 25.
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6
Akademický článek
Incubation of MDCO-216 (ApoA-IMilano/POPC) with Human Serum Potentiates ABCA1-Mediated Cholesterol Efflux Capacity, Generates New Prebeta-1 HDL, and Causes an Increase in HDL Size.
Autor: Kempen HJ; The Medicines Company (Schweiz) GmbH, Talstrasse 59, 8002 Zürich, Switzerland., Schranz DB; Pacific Biomarkers LLC, 645 Elliott Avenue West, Suite 300, Seattle, WA 98119, USA., Asztalos BF; Lipid Metabolism Laboratory, Tufts University, 711 Washington Street, Boston, MA 02111, USA., Otvos J; Liposcience LLC, 2500 Sumner Boulevard, Raleigh, NC 27616, USA., Jeyarajah E; Liposcience LLC, 2500 Sumner Boulevard, Raleigh, NC 27616, USA., Drazul-Schrader D; Vascular Strategies LLC, 5110 Campus Drive, Suite 150, Plymouth Meeting, PA 19462, USA., Collins HL; Vascular Strategies LLC, 5110 Campus Drive, Suite 150, Plymouth Meeting, PA 19462, USA., Adelman SJ; Vascular Strategies LLC, 5110 Campus Drive, Suite 150, Plymouth Meeting, PA 19462, USA., Wijngaard PL; The Medicines Company (Schweiz) GmbH, Talstrasse 59, 8002 Zürich, Switzerland.
Publikováno v: Journal of lipids [J Lipids] 2014; Vol. 2014, pp. 923903. Date of Electronic Publication: 2014 Nov 12.
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7
Akademický článek
Stimulation of Hepatic Apolipoprotein A-I Production by Novel Thieno-Triazolodiazepines: Roles of the Classical Benzodiazepine Receptor, PAF Receptor, and Bromodomain Binding.
Autor: Kempen HJ; Dybly AG, Basel, Switzerland. ; The Medicines Company (Schweiz) GmbH, Zürich, Switzerland., Bellus D; Dybly AG, Basel, Switzerland., Fedorov O; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, Oxford, UK. ; Nuffield Department of Clinical Medicine, Ludwig Institute for Cancer Research, Oxford, UK., Nicklisch S; The Medicines Company (Schweiz) GmbH, Zürich, Switzerland., Filippakopoulos P; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, Oxford, UK. ; Nuffield Department of Clinical Medicine, Ludwig Institute for Cancer Research, Oxford, UK., Picaud S; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, Oxford, UK., Knapp S; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, Oxford, UK. ; Nuffield Department of Clinical Medicine, Target Discovery Institute, Oxford, UK.
Publikováno v: Lipid insights [Lipid Insights] 2013 Dec 22; Vol. 6, pp. 47-54. Date of Electronic Publication: 2013 Dec 22 (Print Publication: 2013).
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8
Akademický článek
Effect of repeated apoA-IMilano/POPC infusion on lipids, (apo)lipoproteins, and serum cholesterol efflux capacity in cynomolgus monkeys.
Autor: Kempen HJ; The Medicines Company (Schweiz) GmbH, Zurich, Switzerland. herman.kempen@themedco.com, Gomaraschi M, Bellibas SE, Plassmann S, Zerler B, Collins HL, Adelman SJ, Calabresi L, Wijngaard PL
Publikováno v: Journal of lipid research [J Lipid Res] 2013 Sep; Vol. 54 (9), pp. 2341-53. Date of Electronic Publication: 2013 Jul 04.
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9
Akademický článek
Genetic analysis of indicators of cholesterol synthesis and absorption: lathosterol and phytosterols in Dutch twins and their parents.
Autor: Boomsma DI; Department of Biological Psychology, Vrije Universiteit, The Netherlands. dorret@psy.vu.nl, Princen HM, Frants RR, Gevers Leuven JA, Kempen HJ
Publikováno v: Twin research : the official journal of the International Society for Twin Studies [Twin Res] 2003 Aug; Vol. 6 (4), pp. 307-14.
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10
Akademický článek
Effects of simvastatin on plasma lipids and apolipoproteins in familial hypercholesterolemic swine.
Autor: Hasler-Rapacz J; Department of Genetics, University of Wisconsin, Madison 53706-1284, USA., Kempen HJ, Princen HM, Kudchodkar BJ, Lacko A, Rapacz J
Publikováno v: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 1996 Jan; Vol. 16 (1), pp. 137-43.
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