Mining the Plasma Proteome for Insights into the Molecular Pathology of Pulmonary Arterial Hypertension

Autor: Lars Harbaum, Christopher J. Rhodes, John Wharton, Allan Lawrie, Jason H. Karnes, Ankit A. Desai, William C. Nichols, Marc Humbert, David Montani, Barbara Girerd, Olivier Sitbon, Mario Boehm, Tatyana Novoyatleva, Ralph T. Schermuly, H. Ardeschir Ghofrani, Mark Toshner, David G. Kiely, Luke S. Howard, Emilia M. Swietlik, Stefan Gräf, Maik Pietzner, Nicholas W. Morrell, Martin R. Wilkins, L Southgate, RD Machado, J Martin, WH Ouwehand, MW Pauciulo, A Arora, K Lutz, F Ahmad, SL Archer, R Argula, ED Austin, D Badesch, S Bakshi, C Barnett, R Benza, N Bhatt, CD Burger, M Chakinala, J Elwing, T Fortin, RP Frantz, A Frost, JGN Garcia, J Harley, H He, NS Hill, R Hirsch, D Ivy, J Klinger, T Lahm, K Marsolo, LJ Martin, SD Nathan, RJ Oudiz, Z Rehman, I Robbins, DM Roden, EB Rosenzweig, G Saydain, R Schilz, RW Simms, M Simon, H Tang, AY Tchourbanov, T Thenappan, F Torres, AK Walsworth, RE Walter, RJ White, J Wilt, D Yung, R Kittles, J Aman, J Knight, KB Hanscombe, H Gall, A Ulrich, HJ Bogaard, C Church, JG Coghlan, R Condliffe, PA Corris, C Danesino, CG Elliott, A Franke, S Ghio, JSR Gibbs, AC Houweling, G Kovacs, M Laudes, RV MacKenzie Ross, S Moledina, M Newnham, A Olschewski, H Olschewski, AJ Peacock, J Pepke-Zaba, L Scelsi, W Seeger, CM Shaffer, O Sitbon, J Suntharalingam, C Treacy, A Vonk Noordegraaf, Q Waisfisz, SJ Wort, RC Trembath, M Germain, I Cebola, J Ferrer, P Amouyel, S Debette, M Eyries, F Soubrier, DA Trégouët

Rationale: Pulmonary arterial hypertension (PAH) is characterized by structural remodeling of pulmonary arteries and arterioles. Underlying biological processes are likely reflected in a perturbation of circulating proteins. Objectives: To quantify a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f363dc083e705c01eb9c6d70a4b67afd
https://www.repository.cam.ac.uk/handle/1810/340465

[Chronic thromboembolic pulmonary hypertension: recognition, diagnosis and treatment]

Autor: Ruigrok D, Petr Symersky, Pwg, Elbers, Kamminga S, Lj, Meijboom, Hj, Bogaard

Publikováno v: Europe PubMed Central

Chronic thromboembolic pulmonary hypertension (CTEPH), characterised by pulmonary hypertension and persistent perfusion defects despite adequate anticoagulation, causes significant morbidity and mortality.- Persistent dyspnoea after acute pulmonary e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::66d561ef54d4210267f4a1253b4aab81
https://pubmed.ncbi.nlm.nih.gov/29027516

Role of Exercise Hemodynamics in the Prediction of Pulmonary Arterial Hypertension in BMPR2 Mutation Carriers.

Autor: Gerges C; Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria; School of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France; Service de Pneumologie et Soins Intensifs Respiratoires, AP-HP, Hôpital Bicêtre, Le Kremlin-Bicêtre, Paris, France., Beurnier A; School of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France; Service de Pneumologie et Soins Intensifs Respiratoires, AP-HP, Hôpital Bicêtre, Le Kremlin-Bicêtre, Paris, France; INSERM UMRS 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, Paris, France., Jaïs X; School of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France; Service de Pneumologie et Soins Intensifs Respiratoires, AP-HP, Hôpital Bicêtre, Le Kremlin-Bicêtre, Paris, France; INSERM UMRS 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, Paris, France., Hervé P; INSERM UMRS 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, Paris, France; Service de Chirurgie Thoracique, Hôpital Marie Lannelongue, Le Plessis-Robinson, Paris, France., Lau EMT; Department of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, NSW, Australia., Girerd B; School of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France; Service de Pneumologie et Soins Intensifs Respiratoires, AP-HP, Hôpital Bicêtre, Le Kremlin-Bicêtre, Paris, France; INSERM UMRS 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, Paris, France., Günther S; Unité d'Explorations Fonctionnelles Respiratoires et du Sommeil, AP-HP, Georges Pompidou European Hospital, Paris, France., Bouchachi A; Service de Physiologie, AP-HP, Hôpital Bicêtre, Le Kremlin-Bicêtre, Paris, France; Service de Cardiologie, AP-HP, Hôpital Bicêtre, Le Kremlin-Bicêtre, Paris, France., Jevnikar M; School of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France; Service de Pneumologie et Soins Intensifs Respiratoires, AP-HP, Hôpital Bicêtre, Le Kremlin-Bicêtre, Paris, France; INSERM UMRS 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, Paris, France., Boucly A; School of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France; Service de Pneumologie et Soins Intensifs Respiratoires, AP-HP, Hôpital Bicêtre, Le Kremlin-Bicêtre, Paris, France; INSERM UMRS 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, Paris, France., Bogaard HJ; Department of Pulmonary Medicine, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands., Simonneau G; School of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France; Service de Pneumologie et Soins Intensifs Respiratoires, AP-HP, Hôpital Bicêtre, Le Kremlin-Bicêtre, Paris, France; INSERM UMRS 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, Paris, France., Sitbon O; School of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France; Service de Pneumologie et Soins Intensifs Respiratoires, AP-HP, Hôpital Bicêtre, Le Kremlin-Bicêtre, Paris, France; INSERM UMRS 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, Paris, France., Savale L; School of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France; Service de Pneumologie et Soins Intensifs Respiratoires, AP-HP, Hôpital Bicêtre, Le Kremlin-Bicêtre, Paris, France; INSERM UMRS 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, Paris, France., Chemla D; Service de Physiologie, AP-HP, Hôpital Bicêtre, Le Kremlin-Bicêtre, Paris, France; INSERM UMRS 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, Paris, France., Humbert M; School of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France; Service de Pneumologie et Soins Intensifs Respiratoires, AP-HP, Hôpital Bicêtre, Le Kremlin-Bicêtre, Paris, France; INSERM UMRS 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, Paris, France., Montani D; School of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France; Service de Pneumologie et Soins Intensifs Respiratoires, AP-HP, Hôpital Bicêtre, Le Kremlin-Bicêtre, Paris, France; INSERM UMRS 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, Paris, France. Electronic address: david.montani@aphp.fr.

Publikováno v: Chest [Chest] 2024 Nov; Vol. 166 (5), pp. 1173-1183. Date of Electronic Publication: 2024 Jul 24.

Emerging multimodality imaging techniques for the pulmonary circulation.

Autor: Rajagopal S; Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Bogaard HJ; Department of Pulmonology, Amsterdam University Medical Center, Location VU Medical Center, Amsterdam, The Netherlands., Elbaz MSM; Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Freed BH; Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Remy-Jardin M; IMALLIANCE-Haut-de-France, Valenciennes, France., van Beek EJR; Edinburgh Imaging, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK., Gopalan D; Department of Radiology, Imperial College Healthcare NHS Trust, London, UK d.gopalan@nhs.net., Kiely DG; Sheffield Pulmonary Vascular Disease Unit and NIHR Biomedical Research Centre Sheffield, Royal Hallamshire Hospital, Sheffield, UK.

Publikováno v: The European respiratory journal [Eur Respir J] 2024 Oct 31; Vol. 64 (4). Date of Electronic Publication: 2024 Oct 31 (Print Publication: 2024).

Deep phenotyping of unaffected carriers of pathogenic BMPR2 variants screened for pulmonary arterial hypertension.

Autor: Tóth EN; Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Pulmonary Medicine, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands.; Contributed equally., Celant LR; Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Pulmonary Medicine, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands.; Contributed equally., Niglas M; Imperial College London, National Heart and Lung Institute, London, UK., Jansen S; Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Pulmonary Medicine, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands., Tramper J; Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Pulmonary Medicine, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands., Baxan N; Imperial College London, National Heart and Lung Institute, London, UK., Ashek A; Imperial College London, National Heart and Lung Institute, London, UK., Wessels JN; Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Pulmonary Medicine, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands., Marcus JT; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands.; Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Radiology and Nuclear Medicine, Amsterdam, The Netherlands., Meijboom LJ; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands.; Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Radiology and Nuclear Medicine, Amsterdam, The Netherlands., Houweling AC; Amsterdam UMC location AMC, Department of Human Genetics, Amsterdam, The Netherlands., Nossent EJ; Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Pulmonary Medicine, Amsterdam, The Netherlands., Aman J; Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Pulmonary Medicine, Amsterdam, The Netherlands., Grynblat J; INSERM UMR_S 999 'Pulmonary Hypertension: Pathophysiology and Novel Therapies', Marie Lannelongue Hospital and Bicêtre Hospital, Le Plessis-Robinson, France.; AP-HP, Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Center, Bicêtre Hospital, Le Kremlin-Bicêtre, France.; Université Paris-Saclay, School of Medicine Gif-sur-Yvette, Gif-sur-Yvette, France.; M3C-Necker, Hôpital Necker-Enfants Malades, AP-HP, Université de Paris Cité, Cardiologie Congénitale et Pédiatrique, Paris, France., Perros F; CarMeN Laboratory, INSERM U1060, INRAE U1397, Université Claude Bernard Lyon 1, Pierre-Bénite, France., Montani D; INSERM UMR_S 999 'Pulmonary Hypertension: Pathophysiology and Novel Therapies', Marie Lannelongue Hospital and Bicêtre Hospital, Le Plessis-Robinson, France.; AP-HP, Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Center, Bicêtre Hospital, Le Kremlin-Bicêtre, France.; Université Paris-Saclay, School of Medicine Gif-sur-Yvette, Gif-sur-Yvette, France., Vonk Noordegraaf A; Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Pulmonary Medicine, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands., Zhao L; Imperial College London, National Heart and Lung Institute, London, UK., de Man FS; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands., Bogaard HJ; Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Pulmonary Medicine, Amsterdam, The Netherlands hj.bogaard@amsterdamumc.nl.; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands.

Publikováno v: The European respiratory journal [Eur Respir J] 2024 Oct 03; Vol. 64 (4). Date of Electronic Publication: 2024 Oct 03 (Print Publication: 2024).