HIVconsv Vaccines and Romidepsin in Early-Treated HIV-1-Infected Individuals: Safety, Immunogenicity and Effect on the Viral Reservoir (Study BCN02)

Autor: Beatriz Mothe, Miriam Rosás-Umbert, Pep Coll, Christian Manzardo, Maria C. Puertas, Sara Morón-López, Anuska Llano, Cristina Miranda, Samandhy Cedeño, Miriam López, Yovaninna Alarcón-Soto, Guadalupe Gómez Melis, Klaus Langohr, Ana M. Barriocanal, Jessica Toro, Irene Ruiz, Cristina Rovira, Antonio Carrillo, Michael Meulbroek, Alison Crook, Edmund G. Wee, Jose M. Miró, Bonaventura Clotet, Marta Valle, Javier Martinez-Picado, Tomáš Hanke, Christian Brander, José Moltó, The BCN02 Study Investigators

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Kick&kill strategies combining drugs aiming to reactivate the viral reservoir with therapeutic vaccines to induce effective cytotoxic immune responses hold potential to achieve a functional cure for HIV-1 infection. Here, we report on an open-label,

Externí odkaz: https://doaj.org/article/488e5500178f4b47bb1f5b03a865f708

Tetravalent Immunogen Assembled from Conserved Regions of HIV-1 and Delivered as mRNA Demonstrates Potent Preclinical T-Cell Immunogenicity and Breadth

Autor: Nathifa Moyo, Edmund G. Wee, Bette Korber, Kapil Bahl, Samantha Falcone, Sunny Himansu, Adrianne L. Wong, Antu K. Dey, Mark Feinberg, Tomáš Hanke

Publikováno v: Vaccines, Vol 8, Iss 3, p 360 (2020)

A vaccine will likely be one of the key tools for ending the HIV-1/AIDS epidemic by preventing HIV-1 spread within uninfected populations and achieving a cure for people living with HIV-1. The currently prevailing view of the vaccine field is to intr

Externí odkaz: https://doaj.org/article/c6a3f4acd94640fab6a5e393110fa76d

Novel Nested Peptide Epitopes Recognized by CD4+ T Cells Induced by HIV-1 Conserved-Region Vaccines

Autor: Nicola Borthwick, Sandra Silva-Arrieta, Anuska Llano, Masafumi Takiguchi, Christian Brander, Tomáš Hanke

Publikováno v: Vaccines, Vol 8, Iss 1, p 28 (2020)

CD4+ T-cell responses play an important role in the immune control of the human immunodeficiency virus type 1 (HIV-1) infection and as such should be efficiently induced by vaccination. It follows that definition of HIV-1-derived peptides recognized

Externí odkaz: https://doaj.org/article/7187e9bef71c4ab59beb9d55c075d499

Preserved central nervous system functioning after use of romidepsin as a latency-reversing agent in an HIV cure strategy

Autor: Muñoz Moreno, Jose Antonio, Carrillo Molina, Sara, Martínez Zalacaín, Ignacio, Miranda, Cristina, Manzardo, Christian, Coll, Pep, Meulbroek, Michael, Hanke, Tomáš, Garolera, Maite, Miró, Josep M., Brander, Christian, Clotet, Bonaventura, Soriano Mas, Carles, Moltó, José, Mothe, Beatriz, BCN02-Neuro Substudy Group

Publikováno v: AIDS
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
O2, repositorio institucional de la UOC
Universitat Oberta de Catalunya (UOC)

Objective: To assess the central nervous system (CNS) impact of a kick&kill HIV cure strategy using therapeutic vaccine MVA.HIVconsv and the histone deacetylase inhibitor (HDACi) romidepsin (RMD) as latency-reversing agent. Design: Neurological obser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f44d733191cb2b320346b9147fb543
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6973

Specificity of CD8+ T-Cell Responses Following Vaccination with Conserved Regions of HIV-1 in Nairobi, Kenya

Autor: Alison Crook, Nathifa Moyo, Hayato Murakoshi, Nicola Borthwick, Christian Brander, Tomáš Hanke, Walter Jaoko, Patricia E. Fast, Francesca Siliquini, Masafumi Takiguchi, Gaudensia Mutua, Peter Hayes, Yehia S. Mohamed, Tomohiro Akahoshi, Anuska Llano, Zara Hannoun, Sandra Silva-Arrieta

Publikováno v: Vaccines
Volume 8
Issue 2
Vaccines, Vol 8, Iss 260, p 260 (2020)
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname

Sub-Saharan Africa carries the biggest burden of the human immunodeficiency virus type 1 (HIV-1)/AIDS epidemic and is in an urgent need of an effective vaccine. CD8+ T cells are an important component of the host immune response to HIV-1 and may need

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d995f462d8ebd4af792f8c3c4a50d3a