Zobrazeno 1 - 10
of 1 287
pro vyhledávání: '"HIV-associated neurocognitive disorders"'
Autor:
Piwai T. Gotora, Keaghan Brown, Darius R. Martin, Rencia van der Sluis, Ruben Cloete, Monray E. Williams
Publikováno v:
Virology Journal, Vol 21, Iss 1, Pp 1-19 (2024)
Abstract Background HIV-1 produces Tat, a crucial protein for transcription, viral replication, and CNS neurotoxicity. Tat interacts with TAR, enhancing HIV reverse transcription. Subtype C Tat variants (C31S, R57S, Q63E) are associated with reduced
Externí odkaz:
https://doaj.org/article/d9527406aa344fd9bd2aa268d3165c55
Publikováno v:
HIV/AIDS: Research and Palliative Care, Vol Volume 16, Pp 229-243 (2024)
Jane Kasozi Namagga,1 Godfrey Zari Rukundo,2 Vincent Batwala,3 Vallence Niyonzima,1 Hanifah Nantongo,1 Grace Nambozi1 1Department of Nursing, Mbarara University of Science and Technology, Mbarara, Uganda; 2Department of Psychiatry, Mbarara University
Externí odkaz:
https://doaj.org/article/35e920bed5694e9a89cd86278e82728e
Autor:
Patrick G. A. Oomen, Charlotte S. Hakkers, Joop E. Arends, Guido E. L. van der Berk, Pascal Pas, Andy I. M. Hoepelman, Berend J. van Welzen, Stefan du Plessis
Publikováno v:
Infectious Diseases and Therapy, Vol 13, Iss 5, Pp 1067-1082 (2024)
Abstract Introduction It is unclear whether neurotoxicity due to the antiretroviral drug efavirenz (EFV) results in neurocognitive impairment in people living with HIV (PLWH). Previously, we found that discontinuing EFV was associated with improved p
Externí odkaz:
https://doaj.org/article/89b5bb64f5f64621904886fd09fc1739
Autor:
Shino Magaki, Ting Zhang, Karam Han, Hilda Mirbaha, William H. Yong, Cristian Achim, Gregory Fishbein, Michael C. Fishbein, Omai Garner, Noriko Salamon, Christopher K. Williams, Miguel A. Valdes-Sueiras, Jeffrey J. Hsu, Theodoros Kelesidis, Glenn E. Mathisen, Helen Lavretsky, Elyse J. Singer, Harry V. Vinters
Publikováno v:
Free Neuropathology, Vol 5 (2024)
Human immunodeficiency virus (HIV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause significant neurologic disease. Central nervous system (CNS) involvement of HIV has been extensively studied, with well-documented invasion of H
Externí odkaz:
https://doaj.org/article/a9e5e4870c37487da14de5e551e1d468
Autor:
Rachel Van Duyne, Elena Irollo, Angel Lin, James A. Johnson, Alain M. Guillem, Erick V. O’Brien, Laura Merja, Bradley Nash, Joshua G. Jackson, Atom Sarkar, Zachary A. Klase, Olimpia Meucci
Publikováno v:
Cells, Vol 13, Iss 13, p 1127 (2024)
HIV-associated neurocognitive disorders (HAND) persist under antiretroviral therapy as a complex pathology that has been difficult to study in cellular and animal models. Therefore, we generated an ex vivo human brain slice model of HIV-1 infection f
Externí odkaz:
https://doaj.org/article/306ea5e6bf6e4dcdabacd95052e8aecf
Publikováno v:
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-14 (2023)
Abstract HIV-associated neurocognitive disorders (HAND) are the result of the activity of HIV-1 within the central nervous system (CNS). While the introduction of antiretroviral therapy (ART) has significantly reduced the occurrence of severe cases o
Externí odkaz:
https://doaj.org/article/c9fffbd724574f39b42669e1364fb12f
Publikováno v:
HIV/AIDS: Research and Palliative Care, Vol Volume 15, Pp 63-70 (2023)
Wei Li,1 Pariya L Fazeli,2 Ge Wang,3 Muhammad Maqbool,1 Victor A Del Bene,4 Kristen Triebel,4 Karli M Martin,4 David Vance2 1School of Health Professions, University of Alabama at Birmingham, Birmingham, AL, USA; 2School of Nursing, University of Ala
Externí odkaz:
https://doaj.org/article/4b38a9ef42544c799ea5aee8f904965e
Autor:
Katherine A. Flack, Emma S. Rainey, Sarah J. Urasa, Sengua Koipapi, Rajesh N. Kalaria, William P. Howlett, Elizabeta B. Mukaetova-Ladinska, Marieke C. J. Dekker, William K. Gray, Richard W. Walker, Catherine L. Dotchin, Himidi Mtwaile, Thomas C. D. Lewis, Lydia G. Stone, Richard J. Q. McNally, Philip C. Makupa, Stella-Maria Paddick
Publikováno v:
Viruses, Vol 16, Iss 6, p 819 (2024)
HIV-associated neurocognitive disorders (HAND) are highly prevalent in those ageing with HIV. High-income country data suggest that vascular risk factors (VRFs) may be stronger predictors of HAND than HIV-disease severity, but data from sub-Saharan A
Externí odkaz:
https://doaj.org/article/c6a092b178304b21a9a5aaab42f54f4c
Autor:
Janine Rodrigues, Karishma Lowton
Publikováno v:
South African Journal of Psychiatry, Vol 29, Iss 0, Pp e1-e8 (2023)
Background: Neurocognitive disorders due to human immunodeficiency virus (HIV) remain highly prevalent, specifically mild forms despite effective antiretroviral therapy (ART). Dolutegravir-based regimens are the first line of treatment for adult HIV-
Externí odkaz:
https://doaj.org/article/6a610a3c18f8470786906a1fe2583f73
Autor:
Ellisiv Clarke, Grace Anderson-Saria, Aloyce Kisoli, Sarah Urasa, Susan Moloney, Ssenku Safic, Jane Rogathi, Richard Walker, Louise Robinson, Stella-Maria Paddick
Publikováno v:
Research Involvement and Engagement, Vol 9, Iss 1, Pp 1-10 (2023)
Plain English summary The population in sub-Saharan Africa is ageing. The majority of people living with HIV infection also live in Africa, and they are ageing now that treatment is widely available. Current research on the chronic complications of a
Externí odkaz:
https://doaj.org/article/24179a99fb7940608f4956c2eaaed1c1