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Akademický článek

High prevalence of pre-treatment and acquired HIV-1 drug resistance mutations among non-citizens living with HIV in Botswana

Autor: Patrick T. Mokgethi, Wonderful T. Choga, Dorcas Maruapula, Natasha O. Moraka, Kaelo K. Seatla, Ontlametse T. Bareng, Doreen D. Ditshwanelo, Graceful Mulenga, Terence Mohammed, Pearl M. Kaumba, Moses Chihungwa, Tafireyi Marukutira, Sikhulile Moyo, Catherine K. Koofhethile, Diana Dickinson, Sununguko W. Mpoloka, Simani Gaseitsiwe

Publikováno v: Frontiers in Microbiology, Vol 15 (2024)

BackgroundApproximately 30,000 non-citizens are living with HIV in Botswana, all of whom as of 2020 are eligible to receive free antiretroviral treatment (ART) within the country. We assessed the prevalence of HIV-1 mutational profiles [pre-treatment

Externí odkaz: https://doaj.org/article/9074ed2378d34979a3500ea0e7911585

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Akademický článek

HIV-1C in-House RNA-Based Genotyping Assay for Detection of Drug Resistance Mutations in Samples with Low-Level Viral Loads

Autor: Bareng OT, Choga WT, Maphorisa ST, Seselamarumo S, Seatla KK, Mokgethi PT, Maruapula D, Mogwele ML, Ditshwanelo D, Moraka NO, Gobe I, Motswaledi MS, Makhema JM, Musonda R, Shapiro R, Essex M, Novitsky V, Moyo S, Gaseitsiwe S

Publikováno v: Infection and Drug Resistance, Vol Volume 15, Pp 7565-7576 (2022)

Ontlametse T Bareng,1,2 Wonderful T Choga,1,2 Segomotso T Maphorisa,3 Sekgabo Seselamarumo,1 Kaelo K Seatla,1 Patrick T Mokgethi,1,4 Dorcas Maruapula,1,4 Mompati L Mogwele,1 Doreen Ditshwanelo,1,5 Natasha O Moraka,1 Irene Gobe,2 Modisa S Motswaledi,2

Externí odkaz: https://doaj.org/article/846ef3e83d94460f975dd8d7a30b1b13

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Akademický článek

Doravirine-associated resistance mutations in antiretroviral therapy naïve and experienced adults with HIV-1 subtype C infection in Botswana

Publikováno v: Journal of Global Antimicrobial Resistance, Vol 31, Iss , Pp 128-134 (2022)

ABSTRACT: Objectives: There are limited data on the prevalence of doravirine (DOR)-associated drug resistance mutations in people with HIV (PWH) in Botswana. This cross-sectional, retrospective study aimed to explore the prevalence of DOR-associated

Externí odkaz: https://doaj.org/article/d7a2551a089a442ebde7a8c9782b8357

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Akademický článek

Prediction of Coreceptor Tropism in HIV-1 Subtype C in Botswana

Publikováno v: Viruses, Vol 15, Iss 2, p 403 (2023)

It remains unknown whether the C-C motif chemokine receptor type 5 (CCR5) coreceptor is still the predominant coreceptor used by Human Immunodeficiency Virus-1 (HIV-1) in Botswana, where the HIV-1 subtype C predominates. We sought to determine HIV-1C

Externí odkaz: https://doaj.org/article/9cefb75749aa4c4c86d4b9634b1e4947

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Akademický článek

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Akademický článek

The Signature Amino Acid Residue Serine 31 of HIV-1C Tat Potentiates an Activated Phenotype in Endothelial Cells

Autor: Malini Menon, Roli Budhwar, Rohit Nandan Shukla, Kiran Bankar, Madavan Vasudevan, Udaykumar Ranga

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

The natural cysteine to serine variation at position 31 of Tat in HIV-1C disrupts the dicysteine motif attenuating the chemokine function of Tat. We ask if there exists a trade-off in terms of a gain of function for HIV-1C Tat due to this natural var

Externí odkaz: https://doaj.org/article/aaeae2a74e914be49cb434cb386a5e14

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Akademický článek

NF-κB Duplications in the Promoter-Variant HIV-1C LTR Impact Inflammation Without Altering Viral Replication in the Context of Simian Human Immunodeficiency Viruses and Opioid-Exposure

Autor: Rajnish S. Dave, Haider Ali, Susmita Sil, Lindsey A. Knight, Kabita Pandey, Lepakshe S. V. Madduri, Fang Qiu, Udaykumar Ranga, Shilpa Buch, Siddappa N. Byrareddy

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Recent spread of the promoter variant (4-κB) Human immunodeficiency virus-1 clade C (HIV-1C) strain is attributed to duplication of the Nuclear Factor Kappa B (NF-κB) binding sites and potential increased heroin consumption in India. To study the u

Externí odkaz: https://doaj.org/article/52d8bbae9a7745919bbe568a4edcd723

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Akademický článek

HIV-1 Subtype C Drug Resistance Mutations in Heavily Treated Patients Failing Integrase Strand Transfer Inhibitor-Based Regimens in Botswana

Autor: Kaelo K. Seatla, Dorcas Maruapula, Wonderful T. Choga, Tshenolo Ntsipe, Nametso Mathiba, Mompati Mogwele, Max Kapanda, Bornapate Nkomo, Dinah Ramaabya, Joseph Makhema, Mompati Mmalane, Madisa Mine, Ishmael Kasvosve, Shahin Lockman, Sikhulile Moyo, Simani Gaseitsiwe

Publikováno v: Viruses, Vol 13, Iss 4, p 594 (2021)

There are limited real-world mutational and virological outcomes data of treatment-experienced persons diagnosed with HIV-1 subtype C (HIV-1 C) who are failing Integrase Strand Transfer Inhibitor-based regimens. Requisition forms sent for HIV-1 genot

Externí odkaz: https://doaj.org/article/72228a78bcd6494f9f95ac7b839b933a

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