Zobrazeno 1 - 10
of 862
pro vyhledávání: '"HIV-1 vaccine"'
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-16 (2024)
Abstract Human immunodeficiency virus type 1 (HIV-1) vaccine immunogens capable of inducing broadly neutralizing antibodies (bNAbs) remain obscure. HIV-1 evades immune responses through enormous diversity and hides its conserved vulnerable epitopes o
Externí odkaz:
https://doaj.org/article/188eec09a91b4c02873a0e0284bafd18
Autor:
Catarina E. Hioe, Xiaomei Liu, Andrew N. Banin, Daniel W. Heindel, Je´romine Klingler, Priyanka G. Rao, Christina C. Luo, Xunqing Jiang, Shilpi Pandey, Tracy Ordonez, Philip Barnette, Maxim Totrov, Jiang Zhu, Arthur Na´das, Susan Zolla-Pazner, Chitra Upadhyay, Xiaoying Shen, Xiang-Peng Kong, Ann J. Hessell
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/e87e857a47b44752a1a5a805fcf33bae
Autor:
Beatriz Perdiguero, Alexandra Hauser, Carmen Elena Gómez, David Peterhoff, Elefthéria Sideris, Carlos Óscar S. Sorzano, Sarah Wilmschen, Marion Schaber, Laura Stengel, Benedikt Asbach, Song Ding, Dorothee Von Laer, Yves Levy, Giuseppe Pantaleo, Janine Kimpel, Mariano Esteban, Ralf Wagner
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe generation of an HIV-1 vaccine able to induce long-lasting protective immunity remains a main challenge. Here, we aimed to modify next-generation soluble, prefusion-stabilized, close-to-native, glycan-engineered clade C gp140 envelope
Externí odkaz:
https://doaj.org/article/8678f1d6bd254349ba452be5f5fce815
Autor:
Catarina E. Hioe, Xiaomei Liu, Andrew N. Banin, Daniel W. Heindel, Jéromine Klingler, Priyanka G. Rao, Christina C. Luo, Xunqing Jiang, Shilpi Pandey, Tracy Ordonez, Philip Barnette, Maxim Totrov, Jiang Zhu, Arthur Nádas, Susan Zolla-Pazner, Chitra Upadhyay, Xiaoying Shen, Xiang-Peng Kong, Ann J. Hessell
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionNeutralizing antibodies (Abs) are one of the immune components required to protect against viral infections. However, developing vaccines capable of eliciting neutralizing Abs effective against a broad array of HIV-1 isolates has been an
Externí odkaz:
https://doaj.org/article/bd3b1a8708a244ec9f1494a4fcb1f13f
Akademický článek
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Autor:
Alessandra Borgognone, Marc Noguera-Julian, Bruna Oriol, Laura Noël-Romas, Marta Ruiz-Riol, Yolanda Guillén, Mariona Parera, Maria Casadellà, Clara Duran, Maria C. Puertas, Francesc Català-Moll, Marlon De Leon, Samantha Knodel, Kenzie Birse, Christian Manzardo, José M. Miró, Bonaventura Clotet, Javier Martinez-Picado, José Moltó, Beatriz Mothe, Adam Burgener, Christian Brander, Roger Paredes, the BCN02 Study Group
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-15 (2022)
Abstract Background The potential role of the gut microbiome as a predictor of immune-mediated HIV-1 control in the absence of antiretroviral therapy (ART) is still unknown. In the BCN02 clinical trial, which combined the MVA.HIVconsv immunogen with
Externí odkaz:
https://doaj.org/article/f4eb4630f5eb4505a01baefcff14f0eb
Publikováno v:
Vaccine: X, Vol 12, Iss , Pp 100222- (2022)
Background: An ongoing challenge in HIV-1 vaccine research is finding a novel HIV-1 envelope glycoprotein (Env)-based immunogen that elicits broadly cross-neutralizing antibodies (bnAbs) without requiring complex sequential immunization regimens to d
Externí odkaz:
https://doaj.org/article/793d6ab891b14089ba9441c607000391
Autor:
Beatriz Perdiguero, Benedikt Asbach, Carmen E. Gómez, Josef Köstler, Susan W. Barnett, Marguerite Koutsoukos, Deborah E. Weiss, Anthony D. Cristillo, Kathryn E. Foulds, Mario Roederer, David C. Montefiori, Nicole L. Yates, Guido Ferrari, Xiaoying Shen, Sheetal Sawant, Georgia D. Tomaras, Alicia Sato, William J. Fulp, Raphael Gottardo, Song Ding, Jonathan L. Heeney, Giuseppe Pantaleo, Mariano Esteban, Ralf Wagner
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
To control HIV infection there is a need for vaccines to induce broad, potent and long-term B and T cell immune responses. With the objective to accelerate and maintain the induction of substantial levels of HIV-1 Env-specific antibodies and, at the
Externí odkaz:
https://doaj.org/article/6036c61a4c684d169531306cb6b2b597
Autor:
Bruna Oriol-Tordera, Anna Esteve-Codina, María Berdasco, Míriam Rosás-Umbert, Elena Gonçalves, Clara Duran-Castells, Francesc Català-Moll, Anuska Llano, Samandhy Cedeño, Maria C. Puertas, Martin Tolstrup, Ole S. Søgaard, Bonaventura Clotet, Javier Martínez-Picado, Tomáš Hanke, Behazine Combadiere, Roger Paredes, Dennis Hartigan-O'Connor, Manel Esteller, Michael Meulbroek, María Luz Calle, Alex Sanchez-Pla, José Moltó, Beatriz Mothe, Christian Brander, Marta Ruiz-Riol
Publikováno v:
EBioMedicine, Vol 78, Iss , Pp 103956- (2022)
Summary: Background: The BCN02-trial combined therapeutic vaccination with a viral latency reversing agent (romidepsin, RMD) in HIV-1-infected individuals and included a monitored antiretroviral pause (MAP) as an efficacy read-out identifying individ
Externí odkaz:
https://doaj.org/article/9f3d6a37e4e5465486ac479f3e27ef6c
Autor:
Clive M. Michelo, Andrew Fiore-Gartland, Jama A. Dalel, Peter Hayes, Jianming Tang, Edward McGowan, William Kilembe, Natalia Fernandez, Jill Gilmour, Eric Hunter
Publikováno v:
Vaccines, Vol 11, Iss 2, p 472 (2023)
An effective HIV vaccine will need to stimulate immune responses against the sequence diversity presented in circulating virus strains. In this study, we evaluate breadth and depth estimates of potential T-cell epitopes (PTEs) in transmitted founder
Externí odkaz:
https://doaj.org/article/baeb58724f0f4d479ef70e11b3fdf9fb