New Concepts in Therapeutic Manipulation of HIV-1 Transcription and Latency: Latency Reversal versus Latency Prevention

Autor: Catherine A. Lewis, David M. Margolis, Edward P. Browne

Publikováno v: Viruses, Vol 15, Iss 8, p 1677 (2023)

Antiretroviral therapy (ART) has dramatically improved the prognosis for people living with HIV-1, but a cure remains elusive. The largest barrier to a cure is the presence of a long-lived latent reservoir that persists within a heterogenous mix of c

Externí odkaz: https://doaj.org/article/cba238474bc144ff9748194d35b66e39

Measuring replication competent HIV-1: advances and challenges in defining the latent reservoir

Autor: Zheng Wang, Francesco R. Simonetti, Robert F. Siliciano, Gregory M. Laird

Publikováno v: Retrovirology, Vol 15, Iss 1, Pp 1-9 (2018)

Abstract Antiretroviral therapy cannot cure HIV-1 infection due to the persistence of a small number of latently infected cells harboring replication-competent proviruses. Measuring persistent HIV-1 is challenging, as it consists of a mosaic populati

Externí odkaz: https://doaj.org/article/f2aadc92435048d68e15bc3e23417f08

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VIP-SPOT: an Innovative Assay To Quantify the Productive HIV-1 Reservoir in the Monitoring of Cure Strategies

Autor: Ángel Bayón-Gil, Sara Morón-López, Javier Martinez-Picado, Julia G. Prado, Victor Urrea, Maria C. Puertas, Maria Cristina O. Salgado, Maria C. Garcia-Guerrero, Ruth Peña, Bonaventura Clotet, Esther Jiménez-Moyano

Publikováno v: mBio, Vol 12, Iss 3 (2021)
mBio
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname

Improved assays are critical to the successful implementation of novel HIV-1 cure strategies, given the limited ability of currently available assays to quantify true effects on the viral reservoir. As interventions based on immune clearance target i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39096fab39adeab08cf0f0ca7e22cf87
https://journals.asm.org/doi/10.1128/mBio.00560-21

The forces driving clonal expansion of the HIV-1 latent reservoir

Autor: Francesco R. Simonetti, Runxia Liu, Ya Chi Ho

Publikováno v: Virology Journal
Virology Journal, Vol 17, Iss 1, Pp 1-13 (2020)

Despite antiretroviral therapy (ART) which halts HIV-1 replication and reduces plasma viral load to clinically undetectable levels, viral rebound inevitably occurs once ART is interrupted. HIV-1-infected cells can undergo clonal expansion, and these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb05b9e1ad7039e075159c2807aacad
https://pubmed.ncbi.nlm.nih.gov/31910871