The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir

Autor: Tung Dinh, Zahira Tber, Juan S. Rey, Seema Mengshetti, Arun S. Annamalai, Reed Haney, Lorenzo Briganti, Franck Amblard, James R. Fuchs, Peter Cherepanov, Kyungjin Kim, Raymond F. Schinazi, Juan R. Perilla, Baek Kim, Mamuka Kvaratskhelia

Publikováno v: mBio, Vol 15, Iss 11 (2024)

ABSTRACT Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are investigational antiretroviral agents that potently impair virion maturation by inducing hyper-multimerization of IN and inhibiting its interaction with viral genomic RNA. The pyrrolop

Externí odkaz: https://doaj.org/article/c69147de7e574451940943ace37a1646

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Identification and Optimization of a Novel HIV‑1 Integrase Inhibitor

Autor: Daniel Adu-Ampratwum, Yuhan Pan, Pratibha C. Koneru, Janet Antwi, Ashley C. Hoyte, Jacques Kessl, Patrick R. Griffin, Mamuka Kvaratskhelia, James R. Fuchs, Ross C. Larue

Publikováno v: ACS Omega, Vol 7, Iss 5, Pp 4482-4491 (2022)

Externí odkaz: https://doaj.org/article/15cbe867ebee4b9a9097b7772e0faf03

The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir.

Autor: Dinh T; Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Tber Z; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, Georgia, USA., Rey JS; Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA., Mengshetti S; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, Georgia, USA., Annamalai AS; Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Haney R; Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Briganti L; Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Amblard F; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, Georgia, USA., Fuchs JR; College of Pharmacy, The Ohio State University, Columbus, Ohio, United States., Cherepanov P; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom., Kim K; ST Pharm Co., Ltd., Seoul, South Korea., Schinazi RF; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, Georgia, USA., Perilla JR; Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA., Kim B; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, Georgia, USA., Kvaratskhelia M; Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 26. Date of Electronic Publication: 2024 Jan 26.

HIV-1 integrase inhibitor resistance among treatment naïve patients in the West of Scotland

Autor: Bradley-Stewart, A., Urcia, C., MacLean, A., Aitken, C., Gunson, R.

Publikováno v: In Journal of Clinical Virology July 2017 92:7-10