Zobrazeno 1 - 10
of 194
pro vyhledávání: '"HIV-1 cure"'
Autor:
Joseph C. Mudd
Publikováno v:
Viruses, Vol 16, Iss 4, p 514 (2024)
The persistence of the latent viral reservoir is the main hurdle to curing HIV-1 infection. SIV infection of non-human primates (NHPs), namely Indian-origin rhesus macaques, is the most relevant and widely used animal model to evaluate therapies that
Externí odkaz:
https://doaj.org/article/e09f594e60b346fe97a15441dcdb30a2
Akademický článek
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Autor:
Sandra Dross, Rasika Venkataraman, Shabnum Patel, Meei-Li Huang, Catherine M. Bollard, Margherita Rosati, George N. Pavlakis, Barbara K. Felber, Katharine J. Bar, George M. Shaw, Keith R. Jerome, James I. Mullins, Hans-Peter Kiem, Deborah Heydenburg Fuller, Christopher W. Peterson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
HIV-specific T cells are necessary for control of HIV-1 replication but are largely insufficient for viral clearance. This is due in part to these cells’ recognition of immunodominant but variable regions of the virus, which facilitates viral escap
Externí odkaz:
https://doaj.org/article/23b8184a8d714211a8e14e49ff22762b
Autor:
Danielle E. Lyons, Priti Kumar, Nadia R. Roan, Patricia A. Defechereux, Cedric Feschotte, Ulrike C. Lange, Niren Murthy, Pauline Sameshima, Eric Verdin, Julie A. Ake, Matthew S. Parsons, Avindra Nath, Sara Gianella, Davey M. Smith, Esper G. Kallas, Thomas J. Villa, Richard Strange, Betty Mwesigwa, Robert L. Furler O’Brien, Douglas F. Nixon, Lishomwa C. Ndhlovu, Susana T. Valente, Melanie Ott
Publikováno v:
Viruses, Vol 15, Iss 11, p 2171 (2023)
Despite remarkable progress, a cure for HIV-1 infection remains elusive. Rebound competent latent and transcriptionally active reservoir cells persevere despite antiretroviral therapy and rekindle infection due to inefficient proviral silencing. We p
Externí odkaz:
https://doaj.org/article/e4df173514554fe9824778fa69c18045
Autor:
Shringar Rao
Publikováno v:
Frontiers in Global Women's Health, Vol 3 (2022)
Of the 38 million people currently living with Human Immunodeficiency Virus type-1 (HIV-1), women, especially adolescents and young women, are disproportionally affected by the HIV-1 pandemic. Acquired immunodeficiency syndrome (AIDS) - related illne
Externí odkaz:
https://doaj.org/article/6199da5093ec4f1aa745c7039a02afb3
Autor:
Ifeanyi Jude Ezeonwumelu, Edurne García-Vidal, Eudald Felip, Maria C. Puertas, Bruna Oriol-Tordera, Lucía Gutiérrez-Chamorro, André Gohr, Marta Ruiz-Riol, Marta Massanella, Bonaventura Clotet, Javier Martinez-Picado, Roger Badia, Eva Riveira-Muñoz, Ester Ballana
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The persistence of latent HIV reservoirs allows for viral rebound upon antiretroviral therapy interruption, hindering effective HIV-1 cure. Emerging evidence suggests that modulation of innate immune stimulation could impact viral latency and contrib
Externí odkaz:
https://doaj.org/article/0c134c9371f546d1bf28e34f8645f39a
Publikováno v:
Viruses, Vol 15, Iss 5, p 1126 (2023)
Gene-modification therapies are at the forefront of HIV-1 cure strategies. Chimeric antigen receptor (CAR)-T cells pose a potential approach to target infected cells during antiretroviral therapy or following analytical treatment interruption (ATI).
Externí odkaz:
https://doaj.org/article/e8ae42e5b7524f0b96429a0ae14449b4
Autor:
Wei Hu, Yan-Jun Li, Cheng Zhen, You-Yuan Wang, Hui-Huang Huang, Jun Zou, Yan-Qing Zheng, Gui-Chan Huang, Si-Run Meng, Jie-Hua Jin, Jing Li, Ming-Ju Zhou, Yu-Long Fu, Peng Zhang, Xiao-Yu Li, Tao Yang, Xiu-Wen Wang, Xiu-Han Yang, Jin-Wen Song, Xing Fan, Yan-Mei Jiao, Ruo-Nan Xu, Ji-Yuan Zhang, Chun-Bao Zhou, Jin-Hong Yuan, Lei Huang, Ya-Qin Qin, Feng-Yao Wu, Ming Shi, Fu-Sheng Wang, Chao Zhang
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Recent studies highlighted that CD8+ T cells are necessary for restraining reservoir in HIV-1-infected individuals who undergo antiretroviral therapy (ART), whereas the underlying cellular and molecular mechanisms remain largely unknown. Here, we enr
Externí odkaz:
https://doaj.org/article/9ceb09f7bcb747d9bf7b54f842701e8e
Autor:
Cristina Gálvez, Judith Grau-Expósito, Victor Urrea, Bonaventura Clotet, Vicenç Falcó, Maria José Buzón, Javier Martinez-Picado
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Knowing the mechanisms that govern the persistence of infected CD4+ subpopulations could help us to design new therapies to cure HIV-1 infection. We evaluated the simultaneous distribution of the HIV-1 reservoir in 13 CD4+ subpopulations fro
Externí odkaz:
https://doaj.org/article/43b6569eee9c4bb6b0fdd961df30d841
Akademický článek
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