The natural history of HIV-1 and HIV-2 infections in adults in Africa: a literature review

Autor: Jaffar Shabbar, Grant Alison D., Whitworth Jimmy, Smith Peter G., Whittle Hilton

Publikováno v: Bulletin of the World Health Organization, Vol 82, Iss 6, Pp 462-469 (2004)

About 30 million people in Africa are estimated to be living with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS), yet data about the natural history of infection on the continent are sparse. We reviewed the literature on

Externí odkaz: https://doaj.org/article/79e2fb6cae7649238941cc62379cfa96

Cytotoxic CD8+T cells expressing CXCR5 are detectable in HIV-1 elite controllers after prolonged in vitro peptide stimulation

Autor: Philipp Adams, Gilles Iserentant, Jean-Yves Servais, Linos Vandekerckhove, Guido Vanham, Carole Seguin-Devaux, the PhenoCure Study Group

Publikováno v: Frontiers in immunology
FRONTIERS IN IMMUNOLOGY
Frontiers in Immunology, Vol 11 (2021)

Antiretroviral therapy (ART) is not curative as HIV-1 persists in long-lived viral reservoirs. Consequently, patients are dependent on life-long drug adherence with possible side effects. To overcome these limitations strategies of a functional cure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a957492001b5604feed9b540abbf56
https://hdl.handle.net/10067/1767410151162165141

HLA Heterozygote Advantage against HIV-1 Is Driven by Quantitative and Qualitative Differences in HLA Allele-Specific Peptide Presentation

Autor: Mary Carrington, Tobias L. Lenz, Federica Pierini, Jacques Fellay, Paul J. McLaren, Jatin Arora

Publikováno v: Molecular biology and evolution, vol. 37, no. 3, pp. 639-650
Molecular Biology and Evolution

Pathogen-mediated balancing selection is regarded as a key driver of host immunogenetic diversity. A hallmark for balancing selection in humans is the heterozygote advantage at genes of the human leukocyte antigen (HLA), resulting in improved HIV-1 c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996687938bd13cc63fdb99d363b53a5f
https://serval.unil.ch/resource/serval:BIB_4A4E20C0A676.P001/REF.pdf

Lymph node migratory dendritic cells modulate HIV-1 transcription through PD-1 engagement

Autor: Riddhima Banga, Khalid Ohmiti, Matthieu Perreau, Kalliopi Ioannidou, Laurence de Leval, Francesco A. Procopio, Caterina Rebecchini, Alessandra Noto, Matthias Cavassini, Olivia Munoz, Giuseppe Pantaleo, Craig Fenwick, Jean-Marc Corpataux

Publikováno v: PLoS pathogens, vol. 15, no. 7, pp. e1007918
PLoS Pathogens, Vol 15, Iss 7, p e1007918 (2019)
PLoS Pathogens

T-follicular helper (Tfh) cells, co-expressing PD-1 and TIGIT, serve as a major cell reservoir for HIV-1 and are responsible for active and persistent HIV-1 transcription after prolonged antiretroviral therapy (ART). However, the precise mechanisms r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a75d9b74797de056653603fd5facae8
https://serval.unil.ch/resource/serval:BIB_1FF4BBBC8958.P001/REF.pdf

Upregulation of Glucose Uptake and Hexokinase Activity of Primary Human CD4+ T Cells in Response to Infection with HIV-1

Autor: Ushani Srenathan, Julianna D. Zeidler, Marios Athanasopoulos, Leonie S. Taams, Thomas R. Eykyn, Maia Kavanagh Williamson, Andrea T. Da Poian, Mariam B. Khan, Naomi Coombes, Hendrik Huthoff, Florian Juszczak

Publikováno v: Viruses, Vol 10, Iss 3, p 114 (2018)
Viruses; Volume 10; Issue 3; Pages: 114
Kavanagh Williamson, M, Coombes, N, Juszczak, F, Athanasopoulos, M, Khan, M, Eykyn, T, Srenathan, U, Taams, L, Diaz Zeidler, J, Da Poian, A & Huthoff, H 2018, ' Upregulation of Glucose Uptake and Hexokinase Activity of Primary Human CD4+ T Cells in Response to Infection with HIV-1 ', Viruses, vol. 10, no. 3 . https://doi.org/10.3390/v10030114
Kavanagh Williamson, M, Coombes, N, Juszczak, F, Athanasopoulos, M, Khan, M, Eykyn, T, Srenathan, U, Taams, L, Dias Zeidler, J, Da Poian, A & Huthoff, H 2018, ' Upregulation of Glucose Uptake and Hexokinase Activity of Primary Human CD4+ T Cells in Response to Infection with HIV-1 ', Viruses-Basel, vol. 10, no. 3, pp. 114 . https://doi.org/10.3390/v10030114
Kavanagh Williamson, M, Coombes, N, Juszczak, F, Athanasopoulos, M, Khan, M B, Eykyn, T R, Srenathan, U, Taams, L S, Dias Zeidler, J, Da Poian, A T & Huthoff, H 2018, ' Upregulation of Glucose Uptake and Hexokinase Activity of Primary Human CD4+ T Cells in Response to Infection with HIV-1 ', Viruses, vol. 10, no. 3, 114 . https://doi.org/10.3390/v10030114
Viruses

Infection of primary CD4+ T cells with HIV-1 coincides with an increase in glycolysis. We investigated the expression of glucose transporters (GLUT) and glycolytic enzymes in human CD4+ T cells in response to infection with HIV-1. We demonstrate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f998e6437910db383a6ad28d8bc6b0f1
http://www.mdpi.com/1999-4915/10/3/114